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| 1 | Safety and efficacy of ledipasvir/sofosbuvir on hepatitis C eradication in hepatitis C virus/human immunodeficiency virus co-infected patients显示文摘AIM To evaluate the safety and efficacy of ledipasvir/sofosbuvir on hepatitis C eradication in patients with hepatitis C virus(HCV)/human immunodeficiency virus(HIV) co-infection in an urban HIV clinic.METHODS A retrospective cohort study of 40 subjects co-infected with HIV-1 and HCV treated with the fixed-dose combination of ledipasvir and sofosbuvir for 12 wk from 2014 to 2016.All patients included were receiving antiretroviral therapy(ART) with HIV RNA values of 100 copies/m L or fewer regardless of baseline HCV RNA level.The primary end point was a sustained virologic response of HCV at 12 wk(SVR12) after the end of therapy.RESULTS Of the 40 patients enrolled,55% were black,22.5% had been previously treated for HCV,and 25% hadcirrhosis.The patients were on a wide range of ART.Overall,39 patients(97.5%) had a SVR 12 after the end of therapy,including rates of 97.1% in patients with HCV genotype 1 a and 100% in those with HCV genotype 1 b.One patient with HCV genotype 3 a was included and achieved SVR12.Rates of SVR12 were similar regardless of previous treatment or the presence of compensated cirrhosis.Only 1 patient experienced relapse at week 12 following treatment and deep sequencing didn't reveal any resistance associated mutation in the NS5A or NS5B region.Interestingly,7(17.5%) patients who were adherent to ART experienced HIV viral breakthrough which resolved after continuing the same ART regimen.Two(5%) patients experienced HIV-1 virologic rebound due to noncompliance with HIV therapy,which resolved after resuming the same ART regimen.No severe adverse events were observed and no patient discontinued treatment because of adverse events.The most common adverse events included headache(12.5%),fatigue(10%),and diarrhea(2.5%).CONCLUSION This retrospective study demonstrated the high rates of SVR12 of ledipasvir/sofosbuvir on HCV eradication in patients co-infected with HCV and HIV,regardless of HCV baseline levels,HCV treatment history or cirrhosis condition.The oral combination of ledipasvir/sofosbuvir represents a safe and well tolerated HCV treatment option that does not require modification for many of the common HIV ART.Occasional HIV virologic rebound occurred but later resolved without the need to change ART. | Xiaoping He Lynne Hopkins George Everett Willie M Carter Cynthia SchroppDyce Khalid Abusaada Vincent Hsu | 2017 | World Journal of Hepatology2017，9，30： | 2 |
| 2 | Three-dimensional structure of human serum albumin显示文摘 | CARTER D C HE X M MUNSON S H | 1989 | Science1989，244，4909： | 1 |
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| 4 | Three-dimension- al structure of Human serum albumin 显示文摘 | Carter D C He X M Munson S H | 1989 | Science1989，244，： | 1 |
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| 8 | A comparison between protein crystals grown with vapor diffusion methods in microgravity and protein crystals using a gel liquid liquid diffusion ground-based method显示文摘 | Miller T Y He X Carter D C | | 0，，1： | 1 |
| 9 | Atomic structure and chemistry of human serum albumin显示文摘 | HE XM CARTER DC | 1992 | Nature1992，358，16： | 1 |
| 10 | Three- dimensional structure of human serum albumin 显示文摘 | CARTER D C HE X M MUNSON S H | 1989 | Science1989，244，4909： | 1 |
| 11 | Three -dimensional structure of Human serum albumin显示文摘 | Carter D C He X M Munson S H | 1989 | Science1989，244，： | 1 |
| 12 | Atomic structure and chemistry of human serum albumin 显示文摘 | HE XIAOMIN CARTER D C | 1992 | Nature1992，358，16： | 1 |
| 13 | Characterization of nanoindentation-induced residual stresses in human enamel by Raman microspectroscopy 显示文摘 | He LH Carter EA Swain MV | 2007 | Anal Bioanal Chem2007，389，4： | 1 |
| 14 | Application of a Real Time Polymerase Chain Reaction Method to Detect Castor Toxin Contamination in Fluid Milk and Eggs 显示文摘 | He X Carter J M Brandon D L | 2007 | J Agric Food Chem2007，55，17： | 1 |
| 15 | Struemm of Human Serllm Albumin显示文摘 | Carter D C He X M | 1990 | Science1990，249，： | 1 |
| 16 | Incidence ofLower-Extr?emity Amputation in American Indians显示文摘 | Resnick HE Carter EA Sosenko lM | 2004 | Diabetes Care2004，27，8： | 1 |
| 17 | The metabolic prospective and redox regulation of macrophage polarization显示文摘 | He C Carter A B | 2015 | J Clin Cell Immunol2015，6，6： | 1 |
| 18 | Structure of human serum albumin显示文摘 | CARTER D C HE Xiao Min | 1990 | Science1990，49，： | 1 |
| 19 | Atomic Structure and Chemistry of Human Serum Albumin显示文摘 | He J Carter D C | 1992 | Nature1992，358，： | 1 |
| 20 | Endothelial Microparticle Formation by Angiotensin II Is Mediated via Ang II Receptor Type I/NADPH Oxidase/ Rho Kinase Pathways Targeted to Lipid Rafts显示文摘 | Dylan Burger Augusto C. Montezano Nobuhiro Nishigaki Ying He Anthony Carter Rhian M. Touyz | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，8： | 1 |
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