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| 1 | Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy显示文摘AIM To determine influence of neoadjuvant-chemotherapy(NAC) over tumor-infiltrating-lymphocytes(TIL) intriple-negative-breast-cancer(TNBC).METHODS TILs were evaluated in 98 TNBC cases who came to Instituto Nacional de Enfermedades Neoplasicas from 2005 to 2010. Immunohistochemistry staining for CD3, CD4, CD8 and FOXP3 was performed in tissue microarrays(TMA) sections. Evaluation of H/E in full-face and immunohistochemistry in TMA sections was performed in pre and post-NAC samples. STATA software was used and P value < 0.05 was considered statistically significant. RESULTS Higher TIL evaluated in full-face sections from pre-NAC tumors was associated to pathologic-complete-response(pCR)(P = 0.0251) and outcome(P = 0.0334). TIL evaluated in TMA sections showed low level of agreement with full-face sections(ICC = 0.017-0.20) and was not associated to pCR or outcome. TIL in post-NAC samples were not associated to response or outcome. PostNAC lesions with pC R had similar TIL levels than those without pCR(P = 0.6331). NAC produced a TIL decrease in full-face sections(P < 0.0001). Percentage of TIL subpopulations was correlated with their absolute counts. Higher counts of CD3, CD4, CD8 and FOXP3 in pre-NAC samples had longer disease-free-survival(DFS). Higher counts of CD3 in pre-NAC samples had longer overallsurvival. Higher ratio of CD8/CD4 counts in pre-NAC was associated with pCR. Higher ratio of CD4/FOXP3 counts in pre-NAC was associated with longer DFS. Higher counts of CD4 in post-NAC samples were associated with pCR.CONCLUSION TIL in pre-NAC full-face sections in TNBC are correlated to longer survival. TIL in full-face differ from TMA sections, absolute count and percentage analysis of TIL subpopulation closely related. | Carlos A Castaneda Elizabeth Mittendorf Sandro Casavilca Yun Wu Miluska Castillo Patricia Arboleda Teresa Nunez Henry Guerra Carlos Barrionuevo Ketty Dolores-Cerna Carolina Belmar-Lopez Julio Abugattas Gabriela Calderon Miguel De La Cruz Manuel Cotrina Jorge Dunstan Henry L Gomez Tatiana Vidaurre | 2016 | World Journal of Clinical Oncology2016，7，5： | 6 |
| 2 | Clinicopathological predictors of long-term benefit in breast cancer treated with neoadjuvant chemotherapy显示文摘AIM To investigate the survival impact of clinicopathological factors, including pathological complete response(p CR) and tumor-infiltrating lymphocytes(s TIL) levels according to subtypes, in breast cancer(BC) patients who received neo-adjuvant chemotherapy(NAC).METHODS We evaluated 435 BC patients who presented and received NAC at the Instituto Nacional de Enfermedades Neoplasicas from 2003 to 2014. s TIL was analyzed as the proportion of tumor stroma occupied by lymphocytes, and was prospectively evaluated on hematoxylin and eosin-stained sections of the preN AC core biopsy. p CR was considered in the absence of infiltrating cancer cells in primary tumor and axillary lymph nodes. Analysis of statistical association between clinical pathological features, s TIL, p CR and survival were carried out using SPSSvs19.RESULTS Median age was 49 years(range 24-84 years) and the most frequent clinical stage was ⅢB(58.3%). Luminal A, Luminal B, HER2-enriched and(triple-negative) TN phenotype was found in 24.6%, 37.9%, 17.7% and 19.8%, respectively. p CR was observed in 11% and median percentage of s TIL was 40%(2%-95%) in the whole population. p CR was associated to Ct1-2(P = 0.045) and to high s TIL(P = 0.029) in the whole population. There was a slight trend towards significance for s TIL(P = 0.054) in Luminal A. s TIL was associated with grade Ⅲ(P < 0.001), no-Luminal A subtype(P < 0.001), RE-negative(P < 0.001), PgR-negative(P < 0.001), HER2-positive(P = 0.002) and p CR(P = 0.029) in the whole population. Longer disease-free survival was associated with grade Ⅰ-Ⅱ(P = 0.006), cN 0(P < 0.001), clinical stage Ⅱ(P = 0.004), ER-positive(P < 0.001), Pg R-positive(P < 0.001), luminal A(P < 0.001) and p CR(P = 0.002). Longer disease-free survival was associated with grade Ⅰ-Ⅱ in Luminal A(P < 0.001), N0-1 in Luminal A(P = 0.045) and TNBC(P = 0.01), clinical stage Ⅱ in Luminal A(P = 0.003) and TNBC(P = 0.038), and pC R in TNBC(P < 0.001). Longer overall survival was associated with grade Ⅰ-Ⅱ(P < 0.001), ER-positive(P < 0.001), PgR-positive(P < 0.001), Luminal A(P < 0.001), cN 0(P = 0.002) and p CR(P = 0.002) in the whole population. Overall survival was associated with clinical stage Ⅱ(P = 0.017) in Luminal A, older age(P = 0.042) in Luminal B, and pC R in TNBC(P = 0.005).CONCLUSION Predictive and prognostic values of clinicopathological features, like p CR and s TIL, differ depending on the evaluated molecular subtype. | Marco Galvez Carlos A Castaneda Joselyn Sanchez Miluska Castillo Lia Pamela Rebaza Gabriela Calderon Miguel De La Cruz Jose Manuel Cotrina Julio Abugattas Jorge Dunstan Henry Guerra Omar Mejia Henry L Gomez | 2018 | World Journal of Clinical Oncology2018，9，2： | 4 |
| 3 | A randomized controlled trial of resistance exercise training to im- prove glyeemic control in older adults with type 2 diabetes显示文摘 | CASTANEDA C LAYNE J E MUNOZ-ORIANS L | 2002 | Diabetes Care2002，，12： | 1 |
| 4 | Nucleation and growth of mineralized bone matrix on silk-hydroxyapatite composite scaffolds显示文摘 | Bhumiratana S Grayson W L Castaneda A | 2011 | Biomaterials2011，32，11： | 1 |
| 5 | Treatment of pel- vic arteriovenous malformations with ethylene vinyl alcohol copol- ymer(Onyx)显示文摘 | Castaneda F Goodwin S C Swischuk J L | 2002 | J Vasc Interv Radiol2002，13，5： | 1 |
| 6 | Oligosaccharides released by pectinase treatment of citrus on seedlings are elicitors of the plant response显示文摘 | Roco A Castaneda P Perez L M | 1993 | Phytochemistry1993，，6： | 1 |
| 7 | Carbon monoxide inhibits hyoxic pulmonary vasoconstriction in rats by a cGMP-independent mechanism显示文摘 | Lopez-lopez JR Castaneda J | 1997 | Arch Eur Physiol1997，434，6： | 1 |
| 8 | Embolization of Pulmonary Arteriovenous Malformation 显示文摘 | Jmaes L Flavio Castaneda H Bob Smouse | 2000 | Intervent Radiol2000，17，2： | 1 |
| 9 | Embolization of pulmonary arteriovenous malformation显示文摘 | James L Flavio Castaneda H Bob Smouse | 2000 | International Radiology2000，17，2： | 1 |
| 10 | Intrahippocampal Amyloid-β (1-40)injections injure medial septal Neurons in rats显示文摘 | Colom L V Castaneda M T Hernandez S | 2011 | Curr Alzheimet Res2011，8，8： | 1 |
| 11 | Comparison of the antidepressant sertraline on diferential depression-like behaviors elicited by restraint stress and repeated corticosterone administration显示文摘 | Ulloa J L Castaneda P Berrios C | 2010 | Pharmacol Biochem Behav2010，97，： | 1 |
| 12 | Extraction of cobalt( Ⅱ )and nickel(Ⅱ )with lauric acid显示文摘 | Jimenez G S Lopez V L M Castaneda M E | 1987 | An Quire1987，83，： | 1 |
| 13 | Zone plate for arbitrary high focal depth显示文摘 | Castaneda J O Berriel-Valdos L R | 1990 | Appl Opt1990，29，： | 1 |
| 14 | Chemical studies of anthocyanins:A review显示文摘 | Castaneda Ovando A Pacheco Hernández M L Páez Hernández M E | 2009 | Food Chemistry2009，113，85： | 1 |
| 15 | A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes显示文摘 | Castaneda C Layne JE Munoz-Orians L | 2002 | Diabetes Care2002，25，12： | 1 |
| 16 | Resistance training to reduce the malnutrition-inflammation complex syndrome of chronic kidney disease显示文摘 | CASTANEDA C GORDON P L PARKER R C | 2004 | Am J Kidney Dis2004，43，4： | 1 |
| 17 | A study of evaluate the effects of single oral doses of BMS-708163 in the cerebrospinal fluid of healthy young men 显示文摘 | TONG G CASTANEDA L WANG J S | 2010 | Alzheimers & Dement2010，6，11： | 1 |
| 18 | Successful treatment oftype 1 diabetes and seizures with combined ketogenic diet and in-sulin显示文摘 | Roxana L?Castaneda A Kenneth J | 2012 | Pediatrics2012，129，51： | 1 |
| 19 | Symmetric branching model for the kinetics of mycelial growth 显示文摘 | VINIEGRA-GONZALEZ G CASTANEDA S G ISUNZA L F | 1993 | Biotechnol Bioeng1993，42，： | 1 |
| 20 | Current situation of emerging technologies for upgrading of heavy oils 显示文摘 | Castaneda L C Munoz J A Ancheyta J | 2014 | Catalysis Today2014，220，： | 1 |
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