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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | An Assessment of Ad- vanced Mobile Services Acceptance: Contributions from TAM and Diffusion Theory Models 显示文摘 | Nicolas C L Castillo F J M Bouwman H | 2008 | Information & Management2008，45，6： | 1 |
| 3 | In situ study of austenite formation by dilatometry in a low carbon microalloyed steel显示文摘 | Martin D S Rivera-Dlaz-del Castillo P E J Garcia de-Andres C | 2008 | Scripta Materialia2008，58，10： | 1 |
| 4 | A blast of gas in the latest Paleocene: simulation first-order effects of massive dissociation of oceanic methane hydrate显示文摘 | Castillo M M Walker J G C | 1997 | Geology1997，25，： | 1 |
| 5 | A second conserved GAF domain cysteine is required for the blue/green photoreversibility of cy- anobacteriochrome TIr0924 from Thermosynecho- coccus elongates 显示文摘 | Rockwell N C Njuguna S L Roberts L Castillo E Parson V L Dwojak S Lagarias J C Spiller S C | 2008 | Biochemistry2008，47，： | 1 |
| 6 | 查看详情显示文摘 | H?pfl H Farfán N Castillo D Santillan R Gutierrez A Daran J C | | 0，，： | 1 |
| 7 | Influence of salinity on germination and seeds viability of two primary colonizers of Mediterranean salt pans显示文摘 | Rubio-Casal A E Castillo J M Luque C J | 2003 | J Arid Environ2003，53，2： | 1 |
| 8 | On the response of a terminated twisted-wire cable excited by a plane-wave electromagnetic field 显示文摘 | Taylor C D Castillo J P | 1980 | IEEE Transactions on Electromagnetic Compat- ibility1980，22，1： | 1 |
| 9 | Influence of salinity on germination and seeds viability of two primary colonizers of Mediterranean salt pans显示文摘 | Rubio-Casal A E Castillo J M Luque C J | 2003 | Journal of Arid Environments2003，53，： | 1 |
| 10 | Development and use of a multiplex real-time quantitative polymerase chain reaction assay for detection and differentiation of porcine circovirus-2 genotypes 2a and 2b in an epidemiological survey显示文摘 | Gagnon C A Del Castillo J R Music N | 2008 | J Vet Diagn Invest2008，20，5： | 1 |
| 11 | Buccal eapnometry for quantitating the severity of hemorrhagic shock 显示文摘 | Cammarata GA Weil MH Castillo C J | 2009 | Shock2009，31，2： | 1 |
| 12 | Organic acids as a substitute for monensin in diets for beef cattle显示文摘 | Castillo C Beneditio J L Mendez J | 2004 | Animal Feed Science and Technology2004，115，12： | 1 |
| 13 | Grammatical and conceptual forces in the attribution of gender by English and Spanish speakers显示文摘 | Sera M Berge C and del Castillo J | 1994 | Cognitive Development1994，，9： | 1 |
| 14 | Analysis of the optical properties of the Orinoco River plume by absorption and fluorescence spectroscopy显示文摘 | Del Castillo C E Coble P G Morell J M | 1999 | Mar Chern1999，66，12： | 1 |
| 15 | Beta2-adrenergic receptor antagonists protect againstventricular fibrillation:in vivo and in vitro evidence forenhanced sensitivity to beta2-adrenergic stimulation inanimals susceptible to sudden death显示文摘 | BILLMAN G E CASTILLO L C HENSLEY J etal | 1997 | Circulation1997，96，6： | 1 |
| 16 | In situ Preparation of a Cholesterol Biosensor显示文摘 | Vidal J C Garcia E Castillo J R | 1999 | Anal Chim Acta1999，385，13： | 1 |
| 17 | Luminescent properties of transparent nanostructured Eu3 + doped SnO2-SiO2 glass-ceramics prepared by the sol-gel method显示文摘 | Del Castillo J Rodríguez V D Yanes A C | 2005 | Nanotechnology2005，16，5： | 1 |
| 18 | Emergence of plasmid mediated AmpC β-lactamasas: Origin, importance,detection and therapeutical options显示文摘 | Seral C Gude M J Castillo FJ | 2012 | Rev Esp Quimioter2012，25，2： | 1 |
| 19 | Plasmamalonaldehyde ( MDA ) and total antioxidant status ( TAS )during lactation in dairy cows显示文摘 | Castillo C Hernandez J Valverde I | 2006 | Res Vet Sci2006，80，： | 1 |
| 20 | On the protective mechanisms of nitric oxide in acute pancreatitis显示文摘 | Werner J Fernndez-del Castillo C Rivera J A | 1998 | Gut1998，43，3： | 1 |
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