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| 1 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 2 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 3 | Source origin of trace elements in PM from regional background, urban and industrial sites of Spain显示文摘 | X. Querol M. Viana A. Alastuey F. Amato T. Moreno S. Castillo J. Pey J. de la Rosa A. Sánchez de la Campa B. Artí?ano P. Salvador S. García Dos Santos R. Fernández-Patier S. Moreno-Grau L. Negral M.C. Minguillón E. Monfort J.I. Gil A. Inza L.A. Ortega J.M | 2007 | Atmospheric Environment2007，，34： | 2 |
| 4 | Blood Pressure Decrease During the Acute Phase of Ischemic Stroke Is Associated With Brain Injury and Poor Stroke Outcome显示文摘 | José Castillo Rogelio Leira María M. García Joaquín Serena Miguel Blanco Antoni Dávalos | 2004 | Stroke: Journal of the American Heart Association2004，，2： | 2 |
| 5 | Levels of anti-Inflammatory cytokines and neurological worsening in acute ischemic stroke显示文摘 | Vila N Castillo J Davalos A | 2003 | Stroke2003，34，3： | 1 |
| 6 | Proinflammatory cy-tokines and early neurological worsening in ischemicstroke显示文摘 | Vila N Castillo J Davalos A | 2000 | Stroke2000，31，10： | 1 |
| 7 | Proinflammatorycytokines and early neurological worsening in ischemicstroke显示文摘 | VILA N CASTILLO J DAVALOS A | 2000 | Stroke2000，31，10： | 1 |
| 8 | Levels of anti inflammatory cytokines and neurological worsening in acute ischemic stroke显示文摘 | Vila N Castillo J Divalos A | 2003 | Stroke2003，34，： | 1 |
| 9 | Proinflammatory cytokines and early neurological worsening in ischemic stroke显示文摘 | Vilan N Castillo J Davalos A | 2000 | Stroke2000，31，10： | 1 |
| 10 | Proinflammatory cytokines and early neurological worsening in ischemic stroke显示文摘 | Vila N Castillo J Davalos A | 2000 | Stroke2000，31，10： | 1 |
| 11 | 查看详情显示文摘 | H?pfl H Farfán N Castillo D Santillan R Gutierrez A Daran J C | | 0，，： | 1 |
| 12 | Proinflammatory cytokines and early neurological wersing in ischemic stroke显示文摘 | Vila N Castillo J Davalos A | 2003 | Stroke2003，34，10： | 1 |
| 13 | Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke 显示文摘 | V'da N Castillo J DOvalos A | 2003 | Stroke2003，34，： | 1 |
| 14 | Effect of ethylene concentration on quality parameters of fresh tomatoes stored using a carbon-heat hybrid ethylene scrubber显示文摘 | Domingo Martínez-Romero Fabián Guillén Salvador Castillo Pedro Javier Zapata Daniel Valero María Serrano | 2008 | Postharvest Biology and Technology2008，，2： | 1 |
| 15 | Proinflammatory cytokines and early neurological worsening in ischemic stroke显示文摘 | Vila N Castillo J Davalos A | 2000 | Stroke2000，31，10： | 1 |
| 16 | Proinflammatory cytokines and early neurological worsening in ischemic stroke显示文摘 | Vila N Castillo J Davalos A | 2000 | Stroke2000，31，10： | 1 |
| 17 | Proinflam- matory cytokines and early neurological worsening in is- chemic stroke 显示文摘 | VILA N CASTILLO J D~VALOS A | 2000 | Stroke2000，31，10： | 1 |
| 18 | Proinflammatory cytokines and early neurological worsening in ischemic stroke显示文摘 | Vila N Castillo J Davalos A | 2000 | Stroke2000，31，： | 1 |
| 19 | Proinflammatory cy-tokines and early neurological worsening in ischemicstroke显示文摘 | Vila N Castillo J Davalos A | 2000 | Stroke2000，31，10： | 1 |
| 20 | Parasitic helminths of the wild rabbit,Oryctolagus cuniculus,in different bioclimatic zones in Tenerife,Canary Islands显示文摘 | Foronda P Del Castillo A Abreu N | 2003 | J Helminthol2003，77，4： | 1 |
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