|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 2 | Factors affecting adherence to antiretroviral therapy in people living with HIV/AIDS显示文摘 | RAMIREZ G P CATE J K | 2003 | J Assoc Nurses AIDS Care2003，14，4： | 1 |
| 3 | Osteoblast-like cell cultures from human stapes 显示文摘 | Dost P Ten Cate WJ Wiemann M | 2002 | Acta Otolaryngol2002，122，8： | 1 |
| 4 | Stress distribution in granular media and nonlinear wave equation显示文摘 | BOUCHAUD J P CATES M E CLAUDIN P J | 1995 | Journal de Physique I1995，5，6： | 1 |
| 5 | An explanation for the central stress minimum in sand piles显示文摘 | WITTMER J P CLAUDIN P CATES M E | 1996 | Nature1996，382，6589： | 1 |
| 6 | Stress propagation and arching in static sand piles显示文摘 | WITTMER J P CATES M E CLAUDIN P | 1997 | Journal de Physique I1997，7，1： | 1 |
| 7 | Stress distribution in granular media and nonlinear wave equation显示文摘 | BOUCHAUD J P CATES M E CLAUDIN P J | 1995 | Journal de Physique I1995，5，6： | 1 |
| 8 | An explanation for the central stress minimum in sand piles显示文摘 | WITTMER J P CLAUDIN P CATES M E | 1996 | Nature1996，382，6589： | 1 |
| 9 | Stress propagation and arching in static sand piles 显示文摘 | WITTMER J P CATES M E CLAUDIN P | 1997 | Journal de Physique I1997，7，1： | 1 |
| 10 | En-hanced mucosal fi brinolytic activity in gastroduo-denal ulcer haemorrhage and the benef icial effect of acid suppression显示文摘 | Vreeburg EM Levi M Rauws EA Deventer SJ Snel P Bartelsman JW Ten Cate JW Tytgat GN | | 0，，07： | 1 |
| 11 | Targeted ablation of oligodendrocytes induces axonal pathology independent of overt demyelination显示文摘 | Oluich LJ Stratton JA Xing YL Ng SW Cate HS Sah P Windels F Kil-patrick TJ Merson TD | | 0，，： | 1 |
| 12 | Severe sinusoidal lesions: a serious and overlooked complication of oxaliplatin-containing chemotherapy? 显示文摘 | Arotcarena R Cates V Berthelemy P | 2006 | Gastroenterol Clin Biol2006，30，11： | 1 |
| 13 | The risk of abortion and stillbirth in antithrombin-, protein C-, and protein S-deficient women显示文摘 | Sanson BJ Friederich PW Simioni P Zanardi S Hilsman MV Girolami A ten Cate JW Prins MH | 1996 | Thrombosis and Haemostasis1996，75，3： | 1 |
| 14 | An association between a functional polymorphism in the monoamine oxidase A gene promoter,impulsive traits and early abuse experiences显示文摘 | Huang Y Y Cate S P Battistuzzi C | 2004 | Neuropsychopharmacology2004，29，8： | 1 |
| 15 | The role of balsam poplar secondary chemicals in controlling soil nutrient dynamics through succession in the Alaskan taiga显示文摘 | Schimel J P Cates R G Ruess R | 1998 | Bioseochemistry1998，42，： | 1 |
| 16 | Automated Amidolytic Method for Determining Heparin,A Hepa rinoid,and a Low-Mr Heparin Fragment,Based on Their Anti-Xa Activity显示文摘 | Ten Cate H Lamping R J Henny C P | | 0，，06： | 1 |
| 17 | Prospects for applications of rol genes for crop improvement显示文摘 | Vander S T P M H(a)nisch ten Cate C H Dons H J M | 1996 | Plant Mol Biol Rep1996，14，： | 1 |
| 18 | Expression of the gap-junction connexins 26 and 30 in the rat cochlea显示文摘 | LAUTERMANN J TEN CATE W J F ALTENHOFF P | | 0，，： | 1 |
| 19 | ‘Part of who we are as a school should include responsibility for well-Being': links between the school environment, mental health and behaviour显示文摘 | Jennifer S Janet S Kate P Cate W | 2006 | Pasto-ral Care2006，，9： | 1 |
| 20 | Long-term efficacy and safety of low molecular weight heparin in chronic hemodialysis patient: a comparison with standard heparin显示文摘 | Nurmohamed MT Ten Cate J Steve rs P | 1991 | A-SAIO Trans1991，37，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员