|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association between the CYBA and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population显示文摘Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease(NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms(SNPs) in the regulatory region of genes encoding NADPH oxidase 4(NOX4) and p22 phox(CYBA) in NAFLD.Methods: A total of 207 biopsy-proven NAFLD patients [simple steatosis(n = 27); nonalcoholic steatohepatitis(NASH)(n = 180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA(unregistered) and NOX4(rs3017887) were determined by direct sequencing of PCR.Results: Associations of CYBA-675 T/A with high-density lipoprotein(HDL)(TT vs TA vs AA; P < 0.01) and triglycerides(TGL)(TT vs XA; P < 0.01) were observed only in NASH patients. For polymorphisms in the NOX4 gene, NOX4(rs3017887) CA + AA genotypes was significant associated with alanine aminotransferase(ALT)(CA + AA vs CC; P = 0.02). However, there was no association of SNPs in the CYBA and NOX4 genes encoding the NADPH oxidase system proteins and the presence of NASH. Regarding the clinical results, it was observed that the most advanced degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus(66.9% vs 37.5%, P < 0.01) and those who were more obese(32.2 vs 29.0 kg/m2,P < 0.01). In addition, serum glucose and insulin levels increased significantly in the presence of NASH.Conclusions: There were associations between the presence of the allele A in the NOX4 SNP and a higher concentration of ALT in the NAFLD population; between the presence of the AA genotype in the polymorphism of the CYBA-675 T/A CYBA gene and a higher level of TGL and lower HDL in NASH patients. The presence of metabolic syndrome was associated with advanced degrees of fibrosis in NAFLD patients. | Fabiola Rabelo Jose Tadeu Stefano Ana Mercedes Cavaleiro Rodrigo Vieira Costa Lima Daniel Ferraz de Campos Mazo Flair Jose Carrilho Maria Lúcia Correa-Giannellac Claudia P.Oliveiraa | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，4： | 2 |
| 2 | 5-Hydroxy-2-(phenyl or styryl) chromones: one-pot synthesis and C-6, C-8 ^13C NMR assignments 显示文摘 | Silva A M S Pinto D C C A Cavaleiro J A S | 1994 | Tetrahedron Lett1994，35，32： | 1 |
| 3 | The influence of the addition of C and N on the wear behaviour of W-S-C/N coatings显示文摘 | NOSSA A CAVALEIRO A | 2001 | Surface & Coatings Technogy2001，，： | 1 |
| 4 | Syntheses of 5-hydroxy-2-(phenyl or styryl)chromones and of some halo derivatives显示文摘 | Pinto D C G A Silva A M S Cavaleiro J A S | 1996 | J Heterocycl Chem1996，33，： | 1 |
| 5 | Synthesis of some new benzylic ethers from 1,8-cineole with antimicrobial activity显示文摘 | SILVESTRE A J D CAVALEIRO J A S FEIO S S | 1999 | Monatshefte für Chemie/Chemical Monthly1999，130，4： | 1 |
| 6 | The tribological behavior of W-S-C films in pin-on-disk testing at elevated temperature显示文摘 | POLCAR T EVARISTO M CAVALEIRO A | 2007 | Vacuum2007，81，： | 1 |
| 7 | Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates显示文摘 | Menezes J C J M D S Kamat S P Cavaleiro J A S | 2011 | Eur J Med Chem2011，46，2： | 1 |
| 8 | Structuralcharacterization of the lignin from the nodes and intemodes ofArundo donaxreed 显示文摘 | Seca A M L Cavaleiro J A S Domingues F M J | 2000 | J Agric Food Chem2000，48，： | 1 |
| 9 | High-temperature tribological prop- erties of CrA1N, CrAISiN and A1CrSiN coatings 显示文摘 | Polcar T Cavaleiro A | 2011 | Surface Coatings Technology2011，206，6： | 1 |
| 10 | Tribological behaviour of re- active and co-sputtered W-S-C coatings显示文摘 | Evaristo M Nossa A Cavaleiro A | 2006 | Cieneia e Tecnolo- gia dos Materiais2006，18，12： | 1 |
| 11 | Tribological properties of self-lubricating TiSiVN coatings at room temperature 显示文摘 | Fernandes F Polcar T Cavaleiro A | 2014 | Surface ~y-Coatings Technology2014，267，： | 1 |
| 12 | The tribological behavior of W-S-C films in pin-on-disk testing at elevated temperature显示文摘 | Polcar T Evaristo M Cavaleiro A | 2007 | Vacuum2007，81，： | 1 |
| 13 | Accumulation of long chain fat-ty acids onto anaerobic sludge under steady state and shock loading condi-tions:effect on acetogenic and methanogenic activity显示文摘 | PEREIRA MA CAVALEIRO AJ MOTA M | 2003 | Water Sci Technol2003，48，： | 1 |
| 14 | Chemical and physical characterization of C(N)-doped W-S sputtered films显示文摘 | NOSSA A CAVALEIRO A | 2004 | Material Research Society2004，19，： | 1 |
| 15 | Tribological behaviour of C-alloyed transition metal dichaleogenides (TMD) coatings in different environments 显示文摘 | Manuel Evaristo Tomas Polcar Albano Cavaleiro | 2008 | Int J Meeh Ma- ter Des2008，4，： | 1 |
| 16 | High temperature behavior of nanolayered CrA1TiN coating: thermal stability, oxida- tion, and tribological properties 显示文摘 | Polcar T Cavaleiro A | 2014 | Surface ~ Coatings Technology2014，257，： | 1 |
| 17 | The tribologieal behav- ior of W-S-C films in pin-on- disk testing at elevated tem- perature 显示文摘 | Polear T Evaristo M Cavaleiro A | 2007 | Vacuum2007，81，： | 1 |
| 18 | Characterization of a Sputtered Amorphous W-C-Co Coating Annealed in Air显示文摘 | Cavaleiro A Vieira M T | 1993 | Thin Sol- id Films1993，228，12： | 1 |
| 19 | Structural characterization of the lignin from the nodes and internodes of Arundo donax reed显示文摘 | Seca A M Cavaleiro J A Domingues F M | 2000 | Journal of Agricultural&Food Chemistry2000，48，3： | 1 |
| 20 | Friction of self-lubricating W-SC sputtered coatings sliding under increasing load显示文摘 | Polcar T Evaristo M Cavaleiro A | 2007 | Plasma Process Polymer2007，4，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员