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| 1 | Utilizing gastric cancer organoids to assess tumor biology and personalize medicine显示文摘While the incidence and mortality of gastric cancer (GC) have declined due to public health programs, it remains the third deadliest cancer worldwide. For patients with early disease, innovative endoscopic and complex surgical techniques have improved survival. However, for patients with advanced disease, there are limited treatment options and survival remains poor. Therefore, there is an urgent need for more effective therapies. Since novel therapies require extensive preclinical testing prior to human trials, it is important to identify methods to expedite this process. Traditional cancer models are restricted by the inability to accurately recapitulate the primary human tumor, exorbitant costs, and the requirement for extended periods of development time. An emerging in vitro model to study human disease is the patient-derived organoid, which is a three-dimensional system created from fresh surgical or biopsy tissues of a patient’s gastric tumor. Organoids are cultured in plastic wells and suspended in a gelatinous matrix, providing a substrate for extension and growth in all dimensions. They are rapid-growing and highly representative of the molecular landscape, histology, and morphology of the various subtypes of GC. Organoids uniquely model tumor initiation and growth, including steps taken by normal stomach cells to transform into invasive, intestinal-type tumor cells. Additionally, they provide ample material for biobanking and screening novel therapies. Lastly, organoids are a promising model for personalized therapy and warrant further investigation in drug sensitivity studies for GC patients. | Miranda Lin Mei Gao Michael J Cavnar Joseph Kim | 2019 | World Journal of Gastrointestinal Oncology2019，11，7： | 7 |
| 2 | Blood neutrophil-to- lymphocyte ratio is prognostic in gastrointestinal stromal tumor 显示文摘 | Perez DR Baser RE Cavnar MJ | 2013 | Ann Surg Oncol2013，20，2： | 1 |
| 3 | Blood neutrophil- to-lymphcyte ratio is prognostic in gastrointestinal stromal tumor显示文摘 | Perez DR Baser RE Cavnar MJ | 2013 | Ann Surg Oncol2013，20，2： | 1 |
| 4 | Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor显示文摘 | Kim T S Cavnar M J Cohen N A | 2014 | Clin Cancer Res2014，20，9： | 1 |
| 5 | Blood neutrophil-to-lym- phocyte ratio is prognostic in gastrointestinal stromal tumor显示文摘 | Perez DR Baser RE Cavnar MJ | 2013 | Ann Surgical Oncol2013，20，2： | 1 |
| 6 | Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor显示文摘 | Kim TS Cavnar M J Cohen NA | 2014 | Clin Cancer Res2014，20，9： | 1 |
| 7 | Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido显示文摘 | Balachandran VP Cavnar MJ Zeng S | 2011 | Nat Med2011，17，9： | 1 |
| 8 | Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido显示文摘 | Balaehandran VP Cavnar MJ Zeng S | 2011 | Nat Med2011，17，9： | 1 |
| 9 | lmatinib po- tentiates antitumor T cell responses in gastrointestinal stro- mal tumor through the inhibition of Ido显示文摘 | Balachandran VP Cavnar MJ Zeng S | 2011 | Nature Med2011，17，9： | 1 |
| 10 | Blood Neu- trophil-to-lymphocyte ratio is prognostic in gastroin- testinal stromal Tumor 显示文摘 | Perez DR Baser RE Cavnar MJ | 2013 | Surgical Oncology2013，20，2： | 1 |
| 11 | Differential regulation of protru- sion and polarity by PI3K during neutrophil motility in live zebrafish 显示文摘 | Yoo S K Deng Q Cavnar P J | 2010 | DevCeIl2010，18，2： | 1 |
| 12 | Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Canc- er Cells显示文摘 | Song J W Cavnar S P Walker A C | 2009 | PLoS One2009，4，6： | 1 |
| 13 | Imatinib potentiates an- titumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido显示文摘 | Balachandran VP Cavnar MJ Zeng S | 2011 | Nat Med2011，17，9： | 1 |
| 14 | Imatinib potenti- ates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition ofldo 显示文摘 | Balachandran VP Cavnar M J Zeng S | 2011 | Nat Med2011，17，9： | 1 |
| 15 | KIT oncogene inhibition drives intratumoral macrophage M2 polarization 显示文摘 | Cavnar M J Zeng S Kim TS | 2013 | J Exp Med2013，210，： | 1 |
| 16 | Children's fitness and access to physical activity facilities显示文摘 | MARLO MICHELLE CAVNAR ZENONG YIN PAULE BARBEAU | 2004 | ESRI Int Conference Health GIS2004，3，： | 1 |
| 17 | Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido显示文摘 | Balachandran VP Cavnar MJ Zeng S | 2011 | Nat Med2011，17，9： | 1 |
| 18 | Imatinib poten-tiates antitumor T cell responses in gastrointestinal stromal rumor through the inhibition of Ido显示文摘 | Balachandran VP Cavnar MJ Zeng S | 2011 | Nat Med2011，17，9： | 1 |
| 19 | Blood neutrophil-to-lymphocyte ratio is prognostic in gastrointestinal stromal tumor显示文摘 | Perez DR Baser RE Cavnar MJ | 2013 | Ann Surg Oncol2013，20，2： | 1 |
| 20 | Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of ido 显示文摘 | Balachandran VP Cavnar MJ Zeng S | 2011 | Nat Med2011，17，9： | 1 |
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