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| 1 | Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease显示文摘BACKGROUND In non-alcoholic fatty liver disease(NAFLD), a high-fat or high-fructose diet increases intestinal permeability and promotes derangement of the gut-liver axis.We hypothesize that, diet could be able to modulate intestinal permeability in patients with NAFLD.AIM To detect diet-induced modification of intestinal permeability in patients with NAFLD undergoing a Mediterranean diet or a low-fat diet.METHODS The current study was a dietary intervention for non-diabetic, patients with biopsy-verified NAFLD and increased transaminases. A crossover design was employed: participants underwent 16 weeks of Mediterranean diet, 16 wk of free wash-out, and 16 weeks of low-fat diet. Both diets were hypocaloric and no consumption of supplements was allowed. All patients were followed bimonthly by a dietitian. Evaluations of clinical and metabolic parameters were completed at baseline and at the end of each dietary period. Intestinal permeability was assessed by chromium-51 ethylene diamine tetraacetate excretion testing(51 CrEDTA).RESULTS Twenty Caucasian patients, 90% male, median age 43 years, body mass index(BMI) 30.9, with biopsy-verified NAFLD were enrolled. At the end of 16 weeks of a Mediterranean diet, a significant reduction in mean body weight(-5.3 ± 4.1 kg,P = 0.003), mean waist circumference(-7.9 ± 4.9 cm, P = 0.001), and mean transaminase levels [alanine aminotransferase(ALT)-28.3 ± 11.9 IU/L, P =0.0001; aspartate aminotransferase(AST)-6.4 ± 56.3 IU/L, P = 0.01] were observed. These benefits were maintained after 16 wk of wash-out and also after16 wk of low-fat diet, without further improvements. Fourteen of the 20 patients had intestinal permeability alteration at baseline(mean percentage retention of51 Cr-EDTA = 5.4%), but no significant changes in intestinal permeability were observed at the end of the 16 wk of the Mediterranean diet or 16 wk of the low-fat diet.CONCLUSION Mediterranean diet is an effective strategy for treating overweight, visceral obesity and serum transaminase in patients with NAFLD. If the Mediterranean diet can improve intestinal permeability in patients with NAFLD, it deserves further investigation. | Marco Biolato Fiorella Manca Giuseppe Marrone Consuelo Cefalo Simona Racco Giacinto A Miggiano Venanzio Valenza Antonio Gasbarrini Luca Miele Antonio Grieco | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 2 | Amniotic band syndrome 显示文摘 | Seeds JW Cefalo RC Herbet WN | 1982 | Am J Obstet Gynecol1982，144，3： | 1 |
| 3 | Preconceptional health care model显示文摘 | Allaire AD Cefalo RC | 1998 | Eur J Obstet Gynecol Reprod Biol1998，78，2： | 1 |
| 4 | Preconception care:a means of prevention显示文摘 | Cefalo RC Bowes WA Jr Moos MK | 1995 | Baillieres Clin Obstet Gynaecol1995，9，3： | 1 |
| 5 | Recurrence of a t(8; 21 ) -positive acute myeloid leukemia in the form of agranulocytic sarcoma involving cranial bones : a diagnostic andtherapeutic challenge 显示文摘 | Di Veroli A Micarelli A Cefalo M | 2013 | Case Rep Hematol2013，2013，24： | 1 |
| 6 | A case-control study on the effects of the apolipoprotein E genotypes in nonalcoholic fatty liver dis- ease 显示文摘 | De Feo E Cefalo C Arzani D | 2012 | Mol BiolRep2012，39，7： | 1 |
| 7 | Preconceptional health care model显示文摘 | Mexander D Mlaire Robert C Cefalo | 1998 | Era' J Obstet Gynecol Reprod Biol1998，78，： | 1 |
| 8 | Hepatic veno-occlusive disease:a chemotherapy-related toxicity in children with malignancies显示文摘 | Cefalo MG Maurizi P Arlotta A | 2010 | Paediatr Drugs2010，12，5： | 1 |
| 9 | Amniotic band syndrom显示文摘 | Seeds J W Cefalo R C Herbert W N P | 1982 | Am J Obstet Gynecol1982，144，3： | 1 |
| 10 | Preconceptional health care model显示文摘 | Allaire AD Cefalo RC | 1998 | Eur J Obstet Gynecol Report Biol1998，78，2： | 1 |
| 11 | Preconception care: a means of prevention显示文摘 | Cefalo RC Bowes WA Jr Moos MK | 1995 | Baillieres Clin Obstet Gynaecol1995，9，： | 1 |
| 12 | A case - control study on the effects of the apolipoprotein E genotypes in nonalcoholic fatty liver disease显示文摘 | De FE Cefalo C Arzani D | 2012 | Mol Biol Rep2012，39，7： | 1 |
| 13 | Technique of early sonographic diagnosis of bilateral cleft lip and palate 显示文摘 | Seeds JW Cefalo RC | 1983 | Obstet Gynecol1983，62，3： | 1 |
| 14 | The clinical content of preconception care: alcohol, tobacco, and illicit drug exposures 显示文摘 | Floyd RL Jack BW Cefalo R | 2008 | AmJObstet Gyneco12008，199，： | 1 |
| 15 | Neoadjuvant chemotherapy with methotrexate, cisplatin, and doxorubicin with or without ifosfamide in nonmetastatic osteosarcoma of the extremity: an Italian sarcoma group trial ISG/OS-1 显示文摘 | Ferrari S Ruggieri P Cefalo G | 2012 | J Clin Oncol2012，30，17： | 1 |
| 16 | Temozolomide is an active agent in children with recurrent medulloblastoma/ primitive neuroectodermal tumor: an Italian multi-institu- tional phase II trial 显示文摘 | Cefalo G Massimino M Ruggiero A | 2014 | Neuro Oncol2014，16，5： | 1 |
| 17 | High response rate to cisplatin/etoposide regimen in childhood low-grade glioma显示文摘 | Massimino M Spreafico F Cefalo G | 2002 | J Clin Oncol2002，20，20： | 1 |
| 18 | Preconception care:a means of pre-vention显示文摘 | Cefalo RC Bowes WJ Moos MK | 1995 | Baillieres Clin Obstet Gynaecol1995，9，3： | 1 |
| 19 | Human parvovirus B 19 and Epstein-Barr virus co-intection in a child with hereditary spherocytosis显示文摘 | Cefalo MG Arlotta A Maurizi P | 2012 | Eur Rev Med Pharmacol Sci2012，16，2： | 1 |
| 20 | Alcoholic and Nonalcoholic Forms of Fatty Liver Disease 显示文摘 | Forgione A Miele L Cefalo C | 2007 | Minerva Gastroenterol Dieto12007，53，1： | 1 |
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