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| 1 | Artificial intelligence in the diagnosis and management of colorectal cancer liver metastases显示文摘Colorectal cancer(CRC)is the third most common malignancy worldwide,with approximately 50%of patients developing colorectal cancer liver metastasis(CRLM)during the follow-up period.Management of CRLM is best achieved via a multidisciplinary approach and the diagnostic and therapeutic decision-making process is complex.In order to optimize patients’survival and quality of life,there are several unsolved challenges which must be overcome.These primarily include a timely diagnosis and the identification of reliable prognostic factors.Furthermore,to allow optimal treatment options,a precision-medicine,personalized approach is required.The widespread digitalization of healthcare generates a vast amount of data and together with accessible high-performance computing,artificial intelligence(AI)technologies can be applied.By increasing diagnostic accuracy,reducing timings and costs,the application of AI could help mitigate the current shortcomings in CRLM management.In this review we explore the available evidence of the possible role of AI in all phases of the CRLM natural history.Radiomics analysis and convolutional neural networks(CNN)which combine computed tomography(CT)images with clinical data have been developed to predict CRLM development in CRC patients.AI models have also proven themselves to perform similarly or better than expert radiologists in detecting CRLM on CT and magnetic resonance scans or identifying them from the noninvasive analysis of patients’exhaled air.The application of AI and machine learning(ML)in diagnosing CRLM has also been extended to histopathological examination in order to rapidly and accurately identify CRLM tissue and its different histopathological growth patterns.ML and CNN have shown good accuracy in predicting response to chemotherapy,early local tumor progression after ablation treatment,and patient survival after surgical treatment or chemotherapy.Despite the initial enthusiasm and the accumulating evidence,AI technologies’role in healthcare and CRLM management is not yet fully established.Its limitations mainly concern safety and the lack of regulation and ethical considerations.AI is unlikely to fully replace any human role but could be actively integrated to facilitate physicians in their everyday practice.Moving towards a personalized and evidence-based patient approach and management,further larger,prospective and rigorous studies evaluating AI technologies in patients at risk or affected by CRLM are needed. | Gianluca Rompianesi Francesca Pegoraro Carlo DL Ceresa Roberto Montalti Roberto Ivan Troisi | 2022 | World Journal of Gastroenterology2022，28，1： | 5 |
| 2 | Actin polymerization in boar spermatozoa: fertilization is reduced with use of cytochalasin D 显示文摘 | Castellani Ceresa L Mattioli M Radaelli G | 1993 | Mol Reprod Dev1993，36，2： | 1 |
| 3 | Complicated sternal dehiscence treated with the strasbourg thoracic osteosyntheses system (STRATOS) and the transposition of greater omentum : a case report 显示文摘 | Ceresa F Casablanca G Patanb F | 2010 | J Cardiothorae Surg2010，，5： | 1 |
| 4 | Cell surface epidermal growth factor receptors increase Src and c-Cbl activity and receptor ubiqui- tylation 显示文摘 | Parks EE Ceresa BP | 2014 | J Biol Chem2014，289，25： | 1 |
| 5 | Cytomegalovirus infections of the nervous system显示文摘 | Cinque P Marenzi R Ceresa D | 1997 | Intervirology1997，40，23： | 1 |
| 6 | Regulation of insulinstimulated GLUT4 translocation by Munc18c in 3T3L1 adipocytes显示文摘 | Thurmond DC Ceresa BP Okada S | 1998 | J Biol Chem1998，273，33： | 1 |
| 7 | Use of a three-dimensional cell culture model to study airway smooth muscle mast cell interactions in airway remodeling显示文摘 | Ceresa CC Knox AJ Johnson SJ | 2009 | Am J Physiol Lung Cell Mol Physiol2009，296，6： | 1 |
| 8 | Rab7 activity affects epidenml growth factor: epi- demml growth factor receptor degradation by regulating endocytic traffick- ing from the late endome显示文摘 | Ceresa B P Bahr S J | 2006 | J Biol Chem2006，281，2： | 1 |
| 9 | Rab7 activity affects epidermal growth factor: epidermal growth factor receptor degrada- tion by regulating endocytic trafficking from the late en- dosome 显示文摘 | Ceresa BP Bahr SJ | 2006 | J Biol Chem2006，281，2： | 1 |
| 10 | Rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome显示文摘 | Ceresa B P Bahr S J | 2006 | J Biol Chem2006，281，2： | 1 |
| 11 | Functionalized mesoporous silica nanopartieles:a possible strategy to target cancer cells re- ducing peripheral nervous system uptake显示文摘 | Ceresa C Nicotini G Rigolio R | 2013 | Curr Med Chem2013，20，20： | 1 |
| 12 | Role of fulvie acid on lead bioaccumulation by Chlorella kesslerii显示文摘 | Slaveykova V I Wilkinson K J Ceresa A | 2003 | Environmental Science and Teehnology2003，37，6： | 1 |
| 13 | Cost/utility ratio in chronic heart failure:comparison between heart failure management program delivered by day-hospital and usual care显示文摘 | Febo O Ceresa M | 2002 | J Am Coll Cardiol2002，40，7： | 1 |
| 14 | Flexure-shear fiber beam-column elements for modeling frame structures under seismic loading-state of the art 显示文摘 | Ceresa P Petrini L Pinho R | 2007 | Journal of Earthquake Engineering2007，，： | 1 |
| 15 | Robust, standardized quan- tifieation of pulmonary emphysema in low does CT exams 显示文摘 | Ceresa M Bastarika G Detorrs JP | 2011 | Acad Radiol2011，18，11： | 1 |
| 16 | Costutility ratio in chronic heart failure comparison between heart failure management delivered by day hospital and usual care显示文摘 | Capomolla S Febo O Ceresa M | 2002 | J Am Coil Cardiol2002，40，7： | 1 |
| 17 | The combined thera- peutical effect of metal - based drugs and radiation therapy: the present status of research显示文摘 | CERESA C BRAVIN A CAVALE'ITI G | 2014 | Curt Med Chem2014，21，20： | 1 |
| 18 | Minimally invasive non-endoscopic vein harvest using a laryngoscope 显示文摘 | Ceresa F Patare F | 2010 | Interact Cardiovasc Thorac Surg2010，10，2： | 1 |
| 19 | Regulation of EGFR endocytic trafficking by rab proteins显示文摘 | Ceresa BP | 2006 | Histol Histopathol2006，21，： | 1 |
| 20 | Right atrial lipoma in patient with Cowden syndrome显示文摘 | CERESA F CALARCO G FRANZE | 2010 | Interact Cardiovasc Thorac Surg2010，11，6： | 1 |
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