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| 1 | Necessity and indications of invasive treatment for Budd-Chiari syndrome显示文摘BACKGROUND:The development of collaterals in Budd-Chiari syndrome has been described and these collaterals play an important role in the presentation of this disease.These collaterals are diagnostic and their use in management strategy has never been evaluated.This study aimed to investigate the indications,feasibility and necessity of invasive treatment for patients with Budd-Chiari syndrome and to determine whether such a strategy is necessary for optimal management.METHODS:Twenty-nine patients who had been treated at our unit were enrolled in this study.Based on physical and biochemical examination,and hemodynamic compensation by collaterals,18 patients underwent radiological intervention (group A),while the other 11 had no invasive treatment (group B).The related hemodynamic parameters were acquired when percutaneous angiography was performed.RESULTS:In group A,all patients underwent successfully inferior vena cava (IVC) balloon angioplasty with or without stenting.Four patients also underwent hepatic vein angioplasty.In these patients,the mean IVC pressure before and after treatment was statistically different (29.3±9.2 vs 15.1±4.6 mmHg,P<0.01).The mean IVC pressure was much lower in group B than in group A (12.9±2.4 vs 29.3±9.2 mmHg,P<0.01),but there was no difference from that of the patients after radiological treatment (12.9±2.4 vs 15.1±4.6 mmHg,P>0.05).Median follow-up was 32.3 months (mean 21.3 months;range 3-61 months).In the course of follow-up,the patients in group A survived with good systemic status except for re-stenosis in one patient who underwent re-canalization of the IVC.In group B,10 patients had good systemic status except one patient who had a meso-caval shunt because of deterioration.CONCLUSIONS:The rationale of 'early diagnosis and early treatment' is not suitable for all patients with Budd-Chiari syndrome.Satisfactory survival can be achieved in some patients without invasive treatment,who are completely compensated by rich collaterals.Nonetheless,a positive treatment procedure should be performed if the patient's situation worsens in the course of regular follow-up. | Department of General Surgery (Fu Y,Sun YL,Ma XX,Xu PQ,Feng LS,Tang Z and Luo CH),Institute of Hepatic Vascular Disease (Sun YL),Department of Radiological Intervention (Guan S and Wang ZW),First Affiliated Hospital,Zhengzhou University School of Medicine,Zhengzhou 450052,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 10 |
| 2 | Effects of partial portal vein arterialization on the hilar bile duct in a rat model显示文摘BACKGROUND: Liver revascularization is frequently required during the enlarged radical operation for hilar cholangio carcinoma involving the hepatic artery. Researchers have carried out a number of experiments applying partial porta vein arterialization (PVA) in clinical practice. In this study we aimed to establish a theoretical basis for clinical application o partial PVA and to investigate the effects of partial PVA on ra hilar bile duct and hepatic functions. METHODS: Thirty rats were randomly and equally assigned into 3 groups: control (group A), hepatic artery ligation+bile duct recanalization (group B), and partial PVA+bile duc recanalization (group C). Proliferation and apoptosis o rat hilar bile duct epithelial cells, arteriolar counts of the peribiliary plexus (PBP) of the bile duct wall, changes in serum biochemistry, and pathologic changes in the bile duc were assessed 1 month after operation. RESULTS: The proliferation of hilar bile duct epithelial cells in group B was greater than in groups A and C (P<0.01). No apoptotic hilar bile duct epithelial cells were detected in any of the groups. The PBP arteriolar counts of the hilar bile duc wall were similar in groups A and C (P>0.05), but the coun was lower in group B than in group A (P<0.01). No statistically significant differences in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and albumin were found in the 3 groups. The gamma-glutamyltransferase value was higher in group B than in groups A and C (P<0.01) The hepatic tissues of groups A and C showed no significan abnormality. Chronic inflammatory changes in the hilar bile duct walls were observed only in group B. CONCLUSION: Partial PVA can restore the arterial blood supply of the hilar bile duct and significantly extenuate the injury to hilar bile duct epithelial cells resulting from hepatic artery ligation. | Shao-Hua Guo, Chong-Hui Li,Yong-Liang Chen, Jian-Ning Song,Ai-Qun Zhang and Cheng Zhou Department of Hepatobiliary Surgery (Guo SH, Li CH, Chen YL, Song JN, Zhang AQ and Zhou C) and Department of Surgical Oncology (Guo SH), General Hospital of PLA, Beijing 100853, China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 8 |
| 3 | Vertebral artery dissection and cerebellar infarction following chiropractic manipulation显示文摘 | Chen WL Chern CH Wu YL | 2006 | Emerg Med J2006，23，1： | 1 |
| 4 | Decreased plasma visfatin concentrations in women with gestational diabetes mellitus显示文摘 | Chan TF Chen YL Lee CH | 2006 | Soc Gynecol Investig2006，13，： | 1 |
| 5 | Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells显示文摘 | Kuo PL Hsu YL Chang CH Chang JK | 2005 | J Pharmacol Exp Ther2005，314，3： | 1 |
| 6 | As exposure,urinary As speciation,and peripheral vascular disease in blackfoot diseasehyperendemic villages in Taiwan显示文摘 | Huang YK Huang YL | 2005 | Toxicol Appl Pharmacol2005，206，： | 1 |
| 7 | Appendicitis in infartcy显示文摘 | Lin YL Lee CH | 2003 | Pediatr Surg Int2003，19，： | 1 |
| 8 | Vertebral artery dissection and cerebellar infarction following chiropractic manipulation 显示文摘 | Chen WL Chern CH Wu YL | 2006 | Emerg Meal J2006，23，1： | 1 |
| 9 | Home exposures,parental atopy,and occurrence of asthma symptoms in adulthood in southern Taiwan显示文摘 | Lee YL Hsiue TR Lee CH | 2006 | Chest2006，129，： | 1 |
| 10 | Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan显示文摘 | Ko YC Huang YL Lee CH | 1995 | J Oral Pathol Med1995，24，10： | 1 |
| 11 | Associations of beta2- adrenergic receptor genotypes and haplotypes with wheezing illness in Taiwanese schoolchildren 显示文摘 | Lee YL Wang ST Tsai CH | 2009 | Allergy2009，64，10： | 1 |
| 12 | Inhibitor of DNA-Bingding-1/ inhibitor of differentiation-1 ( ID-1 ) is implicated in various as- pects of gastric cancer cell biology显示文摘 | Li W Zhang CH Hong YL et al | 2012 | Mol Biol Rep2012，39，11： | 1 |
| 13 | Decreased plasma visfatin concentrations in women with gestational diabetes mellitus显示文摘 | Chan TF Chen YL Lee CH | | 0，，05： | 1 |
| 14 | Obesitysuppresses circulating level and function of endothelialprogenitor cells and heart function显示文摘 | Tsai TH Chai HT Sun CK Yen CH Leu S Chen YL | 2012 | Journal ofTranslational Medicine2012，10，1： | 1 |
| 15 | In vitro dissolution and in vivo gamma scintigraphic evaluation of press-coated salbutamol sulfate tablets显示文摘 | Li W Shi CH Sheng YL | | 0，，4： | 1 |
| 16 | Motor relearning programme for stroke patients: a randomized controlled trial显示文摘 | Dora YL Chetwyn CH Derrick KS | 2006 | Clinical Rehabilitation2006，20，2： | 1 |
| 17 | Dual mechanisms for Lysophosphatidic acid stimulation of human ovarian carcinoma cells 显示文摘 | Hu YL Albanese CH Pestell RG | 2003 | Cancer Invest2003，95，10： | 1 |
| 18 | Decreased plasma visfatin concentrations in women with gestational diabetes mellitus显示文摘 | Chan TF Chen YL Lee CH | 2006 | J Soc Gynecol Investig2006，13，5： | 1 |
| 19 | Acute aortic dissection complicated by acute ischemic stroke: diagnostic challen- ges显示文摘 | Ho CH Chen YL Lin YY | 2012 | Am J Emerg Med2012，30，9： | 1 |
| 20 | Usefulness of Doppler spectral analysis and power Doppler sonography in the differentiation of cervical lymphadenopathies显示文摘 | Wu CH Chang YL Hsu WC | 1998 | AJR1998，171，： | 1 |
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