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| 1 | 腺癌发生过程中的基因改变显示文摘目前已公认,肿瘤的发生是一个多步骤的过程,在这一过程中基因异常改变的积累,最终导致肿瘤表型的出现.基因改变导致肿瘤发生已经不是一个新假说了,很早就已发现了癌症的遗传易感性,癌细胞中染色体发生的改变,以及化学致癌剂引起的DNA的变化.肿瘤发生时的基因水平的改变是多种多样的.包括基因扩增、点突变、基因重排以及特殊基因的缺失.最近,作者提出了一个结直肠癌发生的基因改变模型,包括下列几个方面:首先。 | Cho KR Vogelstein B 郑文岭 | 1993 | 国外医学(肿瘤学分册)1993，23，3： | 2 |
| 2 | Gastrointestinal: Asymptomatic rectal perforation and massive pneumoretroperitoneum in patient with ulcerative colitis treated with mesalamine enemas显示文摘 | YS Choi IT Lee KR Cho JK Kim JP Suh DS Lee | 2013 | J Gastroenterol Hepatol2013，，7： | 2 |
| 3 | Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage 显示文摘 | Kessis TD Slebos RL Nelson WG Kastan MB Plunkett BS Han SM Lorincz AT Hedrick L Cho KR | 1993 | Proc Natl Acad Sci USA1993，90，9： | 1 |
| 4 | Ovarian cancer 显示文摘 | Cho KR Shih I | 2009 | Annu Rev Pathol2009，4，： | 1 |
| 5 | Bromocriptine therapy for the trea- tment of invasive prolactinoma:the single institute expe- rience 显示文摘 | Cho KR Jo KI Shin HJ | 2013 | Brain Tumor Res Treat2013，1，2： | 1 |
| 6 | The DCC gene product in cellular differetiation and cotorectal tumorigenesis显示文摘 | Hedrick L Cho KR Fdaron ER | 1994 | Genes Development1994，8，： | 1 |
| 7 | Bilateral skeletonized internal thoracic artery graftings in off-pump coronary artery bypass:early result of Y versus in situ grafts显示文摘 | Cho KR Chang Wl | 2002 | Ann Thorac Surg2002，74，4： | 1 |
| 8 | The DCC gene product in cellular differentiation and colorectal tumorigenesis显示文摘 | Hedrick L Cho KR Fearon ER | 2001 | Genes Dev2001，8，： | 1 |
| 9 | Identification of a chromo- some 18q gene that is altered in eolorectal eaneers显示文摘 | Fearon Eli Cho KR Nigrn JM | 1990 | Science1990，247，4938： | 1 |
| 10 | Cochlear pathology of the circling mouse : a new mouse model of DFNB6 显示文摘 | Chung WH Kim KR Cho YS | 2007 | Acta Otolaryngol2007，127，3： | 1 |
| 11 | A comparative study of 2D and 3D ultrasonography for evaluation of solid breast masses显示文摘 | Cho KR Seo BK Lee JY | 2005 | Eur J Radial2005，54，3： | 1 |
| 12 | Obligatory role of NR2A for metaplasticity in visual cortex显示文摘 | Philpot BD Cho KR Bear MF | | 0，，： | 1 |
| 13 | Irrigated radiofrequency ablation with transmurality feedback reliably produces Cox Maze lesions in vivo显示文摘 | Hamner CE Potter DD Jr Cho KR | 2005 | Ann Thorac Surg2005，80，12： | 1 |
| 14 | unusual extraction treatment in classlldivision 1 using C-orthodontic mini- Implants显示文摘 | Chung KR Cho JH Kim SH | 2007 | Angle Orthod2007，77，1： | 1 |
| 15 | Dermatofibrosarcoma protuberans of the vulva显示文摘 | Leake JF Buscema J Cho KR | 1991 | Gynecol Oncol1991，41，3： | 1 |
| 16 | Comparative proteomic analysis of low stage and high stage endometrioid ovarian adenocarcinomas显示文摘 | Kim H Wu R Cho KR | | 0，，04： | 1 |
| 17 | Identification of a chromosome 18q gene that is altered in colorectal cancers显示文摘 | Cho KR Nigro JM | 1990 | Science1990，247，4938： | 1 |
| 18 | TAP1 and TAP2 gene polymorphisms in Korean patients with allergic rhinitis显示文摘 | Kim KR Cho SH Choi SJ | 2007 | J Korean Med Sci2007，22，5： | 1 |
| 19 | ITF-2,a downstream target of the Wnt/TCF pathway,is activated in human cancers with beta-catenin defects and promotes neoplastic transformation显示文摘 | Kolligs FT Nieman MT Winer I Hu G Van Mater D Feng Y Smith IM Wu R Zhai Y Cho KR Fearon ER | 2002 | Cancer Cell2002，1，： | 1 |
| 20 | Genetic alt eratio ns in the adenoma-ca rci-noma sequence显示文摘 | Cho KR Vog elstein B | 2006 | Cancer2006，70，54： | 1 |
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