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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 3 | Colloidal behaviour of materials with ionizable group surfaces显示文摘 | HEALY T W CHAN D WHITE L R | 1980 | Pure Appl Chem1980，52，5： | 1 |
| 4 | Replication ofavian and seasonal influenza viruses in human bronchus andlung显示文摘 | Chan R W Y Yuen K M Yu W C L | 2011 | Influenza Other Resp Viruses2011，5，： | 1 |
| 5 | Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra显示文摘 | Yu L R Zhu Z Y Chan K C | 2007 | J Proteome Res2007，6，： | 1 |
| 6 | Effect of heat shock or cold shock treatment on the resistance of lactococcus lactis to freezing and lyophilization显示文摘 | Jeffery R B Chan L | 1999 | Cryobiology1999，，39： | 1 |
| 7 | Determination of antibacterial reagents by liquid chromatography-elec- trospray-mass spectrometry显示文摘 | Fuh M R S Chan S A Wang H L | 2000 | Talanta2000，52，1： | 1 |
| 8 | All optical network consortium-ultrafast TDM network 显示文摘 | BARRY R A CHAN V W S HALL K L | 1996 | IEEE Journal on Selected Areas in Communications1996，14，5： | 1 |
| 9 | Treatment of primary Sjogren's syndrome with hydroxychloroguine 显示文摘 | Fox R I Chan E Benton L | 1988 | Am J Med1988，85，4： | 1 |
| 10 | Terahertz imaging with compressed sensing and phase retrieval显示文摘 | W L Chan M Moravec R Baraniuk | 2008 | Optics Letters2008，33，9： | 1 |
| 11 | Investigation of the effects of peppermint oil and valerian on rat liver and cultured human liver cells显示文摘 | Vo L T Chan D King R G | 2003 | Clin Exp Pharmacol Physiol2003，30，10： | 1 |
| 12 | Oxidized phospholipids,lipoprotein(a),and progression of calcific aortic valve stenosis显示文摘 | CAPOULADE R CHAN K L YEANG C | 2015 | J Am Coll Cardiol2015，66，： | 1 |
| 13 | Reactivity of murine cytokine fusion toxin,diphtheria toxin390 -murine interleukin -3 (DT390-mIL-3),with bone marrow progenitor cells显示文摘 | Chan C H Blazar B R Greenfield L | 1996 | Blood1996，88，： | 1 |
| 14 | Synthesis and spectroscopic properties of heteroleptic Sandwich Complexes with the Porphyrin/Phthalocyanine/Porphyrin Ligand System显示文摘 | J Jiang R L C Lau T W D Chan T C W Mak D K P Ng | 1997 | Inorg Chim Acta1997，255，： | 1 |
| 15 | A computer study of finite amplitude water wave 显示文摘 | CHAN K C STREET R L | 1970 | Journal of Computational Physics1970，6，： | 1 |
| 16 | Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non- steroidal anti-inflammatory drugs: a randomised trial显示文摘 | Francis K L Chan F R Justin C Y | 2002 | Lancet2002，359，1： | 1 |
| 17 | A Ranking of Accounting Research Output in the European Region 显示文摘 | Chan K C Chen C R Cheng L T W | 2006 | Accounting and Business Research2006，36，1： | 1 |
| 18 | NO/Char Reaction at Pul- verzed Coal Flame Conditions 显示文摘 | Levy M R Chan L K Sarofim A F | 1980 | Proceedings of the Combustion Institute1980，18，： | 1 |
| 19 | Palmitate-activated astrocytes via serine palmi- toyhransferase increase BACE 1 in primary neurons by sphingomyelinases 显示文摘 | Liu L Martin R Chan C | 2013 | Neurobiol Aging2013，34，2： | 1 |
| 20 | Amplitude,Width and Interarrival Distributions for Noise Impulses,and Bit Error Rates on Intrabuilding Powerline Communication Networks显示文摘 | Chan M H L Donaldson R W | 1989 | IEEE Trans on Electromagnetic Compatibility1989，31，： | 1 |
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