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| 1 | Rock burst mechanism analysis in an advanced segment of gob-side entry under different dip angles of the seam and prevention technology显示文摘In order to investigate the frequent occurrences of rock burst in gob-side entry during the mining process of the mining zone No. 7, the mechanical model of main roof of fully-mechanized caving mining before breaking was established by the Winkler foundation beam theory, and the stress evolution law of surrounding rock with different dip angles of the seam during the mining process was analyzed by using FLAC3 D. The results show that: with the dip angle changing from 45° to 0°, the solid-coal side of gobside entry begins to form an L-shaped stress concentration zone at a dip angle of 30°, and the stress concentration degree goes to higher and higher levels. However, the stress concentration degree of the coalpillar side goes to lower and lower levels; the influence range and peak stress of the abutment at the lateral strata of adjacent gob increase with dip angle decreasing and reach a maximum value at a dip angle of 0°, but the tailgate is not affected; the abutment pressure superposition of two adjacent gobs leads to stress concentration further enhancing in both sides of gob-side entry. With the influence of strong mining disturbance, rock burst is easily induced by dynamic and static combined load in the advanced segment of gob-side entry. To achieve stability control similar to that in the roadway, the key control strategy is to reinforce surrounding rock and unload both sides. Accordingly, the large-diameter drilling and high-pressure water injection combined unloading and reinforced support cooperative control technology was proposed and applied in field test. The results of Electromagnetic Emission(EME) and field observation showed that unloading and surrounding rock control effect was obvious. | Yang Zengqiang Liu Chang Tang Shichuan Dou Linming Cao Jinglong | 2018 | International Journal of Mining Science and Technology2018，28，6： | 24 |
| 2 | Application of high-pressure water jet technology and the theory of rock burst control in roadway显示文摘This paper puts forward using high-pressure water jet technology to control rock burst in roadway, and analyzes the theory of controlling rock burst in roadway by the weak structure zone model. The weak structure zone is formed by using high-pressure water jet to cut the coal wall in a continuous and rotational way. In order to study the influence law of weak structure zone in surrounding rock, this paper numerically analyzed the influence law of weak structure zone, and the disturbance law of coal wall and floor under dynamic and static combined load. The results show that when the distance between high-pressure water jet drillings is 3 m and the diameter of drilling is 300 mm, continuous stress superposition zone can be formed. The weak structure zone can transfer and reduce the concentrated static load in surrounding rock, and then form distressed zone. The longer the high-pressure water jet drilling is, the larger the distressed zone is. The stress change and displacement change of non-distressed zone in coal wall and floor are significantly greater than that of distressed zone under dynamic and static combined load. And it shows that the distressed zone can effectively control rock burst in roadway under dynamic and static combined load. High-pressure water jet technology was applied in the haulage gate of 250203 working face in Yanbei Coal Mine, and had gained good effect. The study conclusions provide theoretical foundation and a new guidance for controlling rock burst in roadway. | Yang Zengqiang Dou Linming Liu Chang Xu Mengtang Lei Zhen Yao Yahu | 2016 | International Journal of Mining Science and Technology2016，26，5： | 18 |
| 3 | Bispectral index in predicting the prognosis of patients with coma in intensive care unit显示文摘BACKGROUND: The bispectral(BIS) index is a processed electroencephalogram(EEG) parameter with extensive validation and demonstrated clinical utility. The study aimed to investigate the correlation between the BIS index and the prognosis of patients with coma in the ICU.METHODS: A total of 208 patients with coma in the ICU were enrolled in this study. According to the BIS value, the patients were divided into four groups: group I, BIS value 0 to 20; group II, BIS value 21 to 40; group III, BIS value 41 to 60; and group IV, BIS value greater than 60. The difference in BIS values with the differences in prognosis of patients with coma was compared between the four groups, and the prognosis of patients with coma was stratified into consciousness, coma, vegetative state, and brain death. Subsequently, the best cut-off score of BIS values calculated for determining the correlation between BIS value and mental state was proposed.RESULTS: There are no significant differences in the age and APACHE II scores between the four groups(P>0.05). An inverse correlation was observed between BIS value and mental state(r= –0.749, P=0.00). According to the ROC curve, as BIS value was greater than 42.5, there were higher sensitivity and specificity in conscious-coma patients.CONCLUSION: BIS value is correlated with the prognosis of patients with coma in ICU, and BIS value can be a useful marker for estimating the prognosis of comatose patients. | Lin Dou Hong-mei Gao Ling Lu Wen-xiu Chang | 2014 | World Journal of Emergency Medicine2014，5，1： | 16 |
| 4 | Mechanism of rock burst caused by fracture of key strata during irregular working face mining and its prevention methods显示文摘To study the occurrence mechanism of rock burst during mining the irregular working face,the study took irregular panel 7447 near fault tectonic as an engineering background.The spatial fracture characteristic of overlying strata was analyzed by Winkler elastic foundation beam theory.Furthermore,the influence law of panel width to suspended width and limit breaking span of key strata were also analyzed by thin plate theory.Through micro-seismic monitoring,theoretical analysis,numerical simulation and working resistance of support of field measurement,this study investigated the fracture characteristic of overlying strata and mechanism of rock burst in irregular working face.The results show that the fracture characteristic of overlying strata shows a spatial trapezoid structure,with the main roof being as an undersurface.The fracture form changes from vertical‘‘O-X'type to transverse‘‘O-X'type with the increase of trapezoidal height.From the narrow mining face to the wide mining face,the suspended width of key strata is greater than its limit breaking width,and a strong dynamic load is produced by the fracture of key strata.The numerical simulation and micro-seismic monitoring results show that the initial fracture position of key strata is close to tailgate 7447.Also there is a high static load caused by fault tectonic.The dynamic and static combined load induce rock burst.Accordingly,a cooperative control technology was proposed,which can weaken dynamic load by hard roof directional hydraulic fracture and enhance surrounding rock by supporting system. | Zengqiang Yang Chang Liu Hengzhong Zhu Fuxing Xie Linming Dou Jianhang Chen | 2019 | International Journal of Mining Science and Technology2019，29，6： | 12 |
| 5 | Clinical characteristics of early and late drug-eluting stent in-stent restenosis and mid-term prognosis after repeated percutaneous coronary intervention显示文摘Background:The mechanism and characteristics of early and late drug-eluting stent in-stent restenosis(DES-ISR)have not been fully clarified.Whether there are different outcomes among those patients being irrespective of their repeated treatments remain a knowledge gap.Methods:A total of 250 patients who underwent initial stent implantation in our hospital,and then were readmitted to receive treatment for the reason of recurrent significant DES-ISR in 2016 were involved.The patients were categorized as early ISR(<12 months;E-ISR;n=32)and late ISR(≥12 months;L-ISR;n=218).Associations between patient characteristics and clinical performance,as well as clinical outcomes after a repeated percutaneous coronary intervention(PCI)were evaluated.Primary composite endpoint of major adverse cardiac events(MACEs)included cardiac death,non-fatal myocardial infarction(MI),or target lesion revascularization(TLR).Results:Most baseline characteristics are similar in both groups,except for the period of ISR,initial pre-procedure thrombolysis in myocardial infarction,and some serum biochemical indicators.The incidence of MACE(37.5%vs.5.5%;P<0.001)and TLR(37.5%vs.5.0%;P<0.001)is higher in the E-ISR group.After multivariate analysis,E-ISR(odds ratio[OR],13.267;[95%CI 4.984-35.311];P<0.001)and left ventricular systolic dysfunction(odds ratio[OR],6.317;[95%CI 1.145-34.843];P=0.034)are the independent predictors for MACE among DES-ISR patients in the mid-term follow-up of 12 months.Conclusions:Early ISR and left ventricular systolic dysfunction are associated with MACE during the mid-term follow-up period for DES-ISR patients.The results may benefit the risk stratification and secondary prevention for DES-ISR patients in clinical practice. | Jian-Feng Zheng Ting-Ting Guo Yuan Tian Yong Wang Xiao-Ying Hu Yue Chang Hong Qiu Ke-Fei Dou Yi-Da Tang Jin-Qing Yuan Yong-Jian Wu Hong-Bing Yan Shu-Bin Qiao Bo Xu Yue-Jin Yang Run-Lin Gao | 2020 | Chinese Medical Journal2020，，22： | 5 |
| 6 | Two new compounds from Zingiber officinale显示文摘新周期的 diarylheptanoid, 1,5-epoxy-3-hydroxy-1-(3-methoxy-4,5-dihydroxyphenyl )-7-(4-hydroxyphenyl)-heptane (1 ) ,以及新单音的萜烯, 10-O- β - d-glucopyranosyl-hydroxy cineole (2 ) 从姜 officinale 的根茎被孤立。混合物的结构 1 和 2 被建立基于他们的光谱数据。另外,这些混合物的抗氧化剂活动也被测量。 | Yu Zhao Qiao Feng Tao Rong Ping Zhang Chang Xin Zhou Hui Dou Shu Yun Shi Ye Cheng Xiao Lian Li Sun Su Zeng Ke Xin Huang Xiao Dong Zhang Xiao Kun Li | 2007 | Chinese Chemical Letters2007，18，10： | 4 |
| 7 | Physiological levels of ATP negatively regulate proteasome function显示文摘由 ubiquitin-proteasome 系统的细胞内部的蛋白质降级是 ATP 依赖者,和最佳的 ATP 集中激活 proteasome 在 vitro 的功能是 ~ 100 渭 M。细胞内部的 ATP 层次在在这个范围以内的水平通常在低 millimolar 范围,而是 ATP 被显示在 vitro 禁止 proteasome peptidase 活动。这里,我们报导支持在生理的层次的细胞内部的 ATP 双向地调整的一个假设的新证据 26S proteasome 在房间的解朊的功能。首先,我们证实 ATP 在 vitro 在 26S proteasome 上施加了双向规定,与最佳的 ATP 集中(在 50 和 100 渭 M 之间) 刺激 proteasome 像糜蛋白酶的活动。第二,我们发现操作细胞内部的 ATP 层次也在有教养的房间在 proteasome 特定的蛋白质底层的层次导致了双向变化。最后,测量增加提高的细胞内部的 ATP,当减少的细胞内部的 ATP 稀释了导致房间死亡的 proteasome 抑制的能力时。这些数据强烈建议在生理的集中范围以内的内长的 ATP 能在 proteasome 活动施加否定影响,允许房间到很快,在应力下面的 ATP 减小上的 upregulate proteasome 活动调节。 | Hongbiao Huang Xiaoyan Zhang Shujue Li Ningning Liu Wen Elan Emily McDowell Ping Zhou Canguo Zhao Haiping Guo Change Zhang Changshan Yang Guangmei Wen Xiaoxian Dong Li Lu Ningfang Ma Weihua Dong Q Ping Dou Xuejun Wang Jinbao Liu | 2010 | Cell Research2010，20，12： | 4 |
| 8 | Combined detection and subclass characteristics analysis of CTCs and CTECs by SE-iFISH in ovarian cancer显示文摘Objective:Hematogenous metastasis is essential for the progression of ovarian cancer(OC),and circulating tumor cells(CTCs)are part of the metastatic cascade.However,the detection rate of CTC is low due to the use of less sensitive detection methods.Therefore,this study aimed to detect CTCs and circulating tumorigenic endothelial cells(CTECs)in patients with OC using subtraction enrichment and immunostaining and fluorescence in situ hybridization(SE-iFISH).Methods:We enrolled a total of 56 subjects,including 20 OC patients and 36 ovarian benign tumor patients.CTCs and CTECs were captured by subtraction enrichment(SE)and counted and classified according to immunofluorescence staining of tumor markers(TMs)carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)combined with fluorescence in situ hybridization(iFISH)of chromosome 8(Chr8)aneuploidy.The diagnostic value and subtype characteristics of CTCs and CTECs were investigated.Results:The detection rate of CTCs by SE-iFISH was high.Compared with CA125 and HE4,Chr8 aneuploidy was the major identification feature of CTC.CTC counts in OC were statistically higher than those in benign groups.CTC and CTEC with≥pentaploidy were detected in both groups,illustrating the poor diagnostic value of CTC or CTEC.Distributions of triploid and tetraploid CTC subtypes were significantly different,and combined detection of triploid and tetraploid CTCs showed the best diagnostic value.In contrast,the distribution of CTECs in the OC and benign groups had no statistically significant difference.Small CTCs accounted for over 1/3 of the total CTC count.We also found that small CTCs and CTECs primarily comprised triploid cells,while large CTCs and CTECs mainly comprised pentaploidy and beyond.Conclusions:The application of SE-iFISH offered a more comprehensive understanding of heterogeneous CTCs and CTECs in OC.Analysis of subclass characteristics of the CTCs and CTECs according to Chr8 aneuploidy and cell size may broaden their potential clinical utility and deepen mechanistic studies in OC. | Hongyan Cheng Shang Wang Wenqing Luan Xue Ye Sha Dou Zhijian Tang Honglan Zhu Peter Ping Lin Yi Li Heng Cui Xiaohong Chang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 3 |
| 9 | Three new diarylheptanoids and their antioxidant property显示文摘三新 diarylheptanoids,即,钠(5S,2E )-1,7-bis(4-hydroxyphenyl)-1-hydroxy-2-hepten-5-sulfonate (1 ) ,钠(5R,2E )-1,7-bis(4-hydroxyphenyl)-1-hydroxy-2-hepten-5-sulfonate (2 ) 和 3,5-diacetoxy-1-(3-methoxy-4,5-dihydroxyphenyl )-7-(4-hydroxy-3-methoxyphenyl)heptane (3 ) 从姜 officinale 的根茎被孤立。新混合物的结构根据分光镜的方法被阐明。3 的抗氧化剂活动在包含 DPPH 自由激进分子和超级氧化物阴离子激进分子的 vitro 模型旁边是 assayed。 | Chang Xin Zhou Xiang Yi Zhang Xiao Wu Dong Qiao Feng Tao Hui Dou Rong Ping Zhang Ke Xin Huang Xiao Kun Li Chang Xiang Chen Su Zeng Yu Zhao | 2007 | Chinese Chemical Letters2007，18，10： | 2 |
| 10 | SaC‐FRAPP: a scalable and cost‐effective framework for privacy preservation over big data on cloud显示文摘 | Xuyun Zhang Chang Liu Surya Nepal Chi Yang Wanchun Dou Jinjun Chen | 2013 | Concurrency Computat: Pract Exper2013，，18： | 2 |
| 11 | Determination of benzene,toluene,ethylbenzene,xylenes in water at sub-ng L-1 levels by solid-phase microextraction coupled to cryo-trap gas chromatography-mass spectrometry显示文摘 | Lee M R Chang C M Dou J P | 2007 | Chemosphere2007，69，： | 1 |
| 12 | Determination of benzene, toluene, ethylbenzene, xylenes in water at sub-ngL - I lev- els by solid-phase microextraction coupled to cryotrap gas chro-matography-mass spectrometry 显示文摘 | RONG LEEM M IN CHANG C DOU J | 2007 | Chem Osphere2007，69，1： | 1 |
| 13 | Analysis and comparison of decline models:A field case study for the Intercampo Oil Field,Venezuela显示文摘 | Dou Hong'en Chen Changchun Chang Yuwen | 2009 | SPE Reservoir Evaluation & Engineering2009，12，1： | 1 |
| 14 | Distribution of China' s city Population, 1982显示文摘 | Chang Sen- dou | 1986 | Urban Geography1986，7，4： | 1 |
| 15 | Transcriptome and expressionprofiling analysis of Leuciscus waleckii: an explorationof the alkali-adapted mechanisms of a freshwaterteleost显示文摘 | Chang Y M Tang R Dou X J | 2014 | Mol Biosyst2014，10，： | 1 |
| 16 | Fault linkage patterns and their control on the formation of the petroleum systems of the Erlian Basin, Eastern China 显示文摘 | Dou L R Chang L | 2003 | Marine and Pe- troleum Geology2003，22，20： | 1 |
| 17 | Effect of type 2 diabetes mellitus on the clinical severity and treatment outcome in patients with pul- monary tuberculosis:a potential role in the emergence of muhidrug- resistance显示文摘 | Chang JT Dou HY Yen CL et a/ | 2011 | J Fonn Med Assoc2011，110，6： | 1 |
| 18 | Antigenic heterogeneity of the hepatitis C virus NS5A protein显示文摘 | Dou X G Talekar G Chang J | 2002 | J Clin Microbiol2002，40，1： | 1 |
| 19 | Emission of polycyclie aromatic hydrocarbons from indoor straw burning and emission inventory updating in China 显示文摘 | Zhang Y X Dou H Chang B | 2008 | Annals of the New YorkAcademy of Sciences2008，1140，： | 1 |
| 20 | Paraquat inhibits cell viability viaenhanced oxidative stress and apoptosis in human neural progenitor cells显示文摘 | Chang X Lu W Dou T | 2013 | Chemieo Biologic Int2013，206，2： | 1 |
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