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| 1 | Upper mantle anisotropy of the eastern Himalayan syntaxis and surrounding regions from shear wave splitting analysis显示文摘Polarization analysis of teleseismic data has been used to determine the XKS(SKS,SKKS,and PKS)fast polarization directions and delay times between fast and slow shear waves for 59 seismic stations of both temporary and permanent broadband seismograph networks deployed in the eastern Himalayan syntaxis(EHS)and surrounding regions.The analysis employed both the grid searching method of the minimum tangential energy and stacking analysis methods to develop an image of upper mantle anisotropy in the EHS and surrounding regions using the newly obtained shear wave splitting parameters and previously published results.The fast polarization directions are oriented along a NE-SW azimuth in the EHS.However,within the surrounding regions,the fast directions show a clockwise rotation pattern around the EHS from NE-SW,to E-W,to NW-SE,and then to N-S.In the EHS and surrounding regions,the fast directions of seismic anisotropy determined using shear wave splitting analysis correlate with surficial geological features including major sutures and faults and with the surface deformation fields derived from global positioning system(GPS)data.The coincidence between structural features in the crust,surface deformation fields and mantle anisotropy suggests that the deformation in the crust and lithospheric mantle is mechanically coupled.In the EHS,the coherence between the fast directions and the NE direction of the subduction of the Indian Plate beneath the Tibetan Plateau suggests that the lithospheric deformation is caused mainly by subduction.In the regions surrounding the EHS,we speculate that a westward retreat of the Burma slab could contribute to the curved anisotropy pattern.The Tibetan Plateau is acted upon by a NE-trending force due to the subduction of the Indian Plate,and also affected by a westward drag force due to the westward retreat produced by the eastward subduction of the Burma slab.The two forces contribute to a curved lithospheric deformation that results in the alignment of the upper mantle peridotite lattice parallel to the deformation direction,and thus generates a curved pattern of fast directions around the EHS. | CHANG LiJun WANG ChunYong DING ZhiFeng YOU HuiChuan LOU Hai SHAO CuiRu | 2015 | Science China Earth Sciences2015，58，10： | 16 |
| 2 | Analysis of Allergens in 5473 Patients with Allergic Diseases in Harbin, China显示文摘Objective To analyze the allergic status to common inhalant allergens and food allergens in clinical patients in Harbin in northeastern China and provide evidence to develop the prevention strategy of allergic disease. Methods The data were collected from 5473 patients with clinical suspected allergic diseases seeking medical care in the Second Affiliated Hospital of Harbin Medical University. Among these patients, 2530(46.2%) were males aged 0-86 years, the youngest was only 1 month old and 2579(47.1%) were young children and teenagers. The serum specific Immunoglobulin E(sIgE) to 14 kinds of common allergens and serum total IgE were detected by using AllergyScreen test(Mediwiss Analytic GmbH, Moers, Germany). Results In 5473 subjects the positive rate of sIgE was 33.1%(n=1813). Cow milk(6.9%) and wheat(3.1%) were the most common food allergens, followed by house dust mite mix(12.5%) and mould mix(9.4%) and the age and gender specific differences in the positive rate were significant. For the children aged <7 years the positive rates to cow milk, beef-mutton, and egg white/egg yolk were high, but the positive rates to house dust mite mix, ragweed estragon, and mould mix were low(P<0.05). For the adults the positive rates to aeroallergens were high while the rates to food allergens were low. Conclusion The results from this study showed that the food allergens in Harbin had geographic characteristics, which support the viewpoint that the environment factors play an important role in the incidence of allergic diseases. Also, the detection of sIgE and total IgE are essential to identify relevant allergens for the purpose of early diagnosis, management and prevention of allergic disease. | CHANG Man Li SHAO Bing LIU Yan Hong LI Lu Lu PEI Li Chun WANG Bin You | 2013 | Biomedical and Environmental Sciences2013，26，11： | 11 |
| 3 | Spontaneous Coronary Artery Dissection as a Cause of Acute Myocardial Infarction in Young Female Population: A Single-center Study显示文摘 | Pei-Na Meng Chen Xu Wei You Zhi-Ming Wu Du-Jiang Xie Hang Zhang Chang Pan Fei Ye | 2017 | Chinese Medical Journal2017，，13： | 10 |
| 4 | MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosis显示文摘Current research indicates that beta cell loss in type 2 diabetes may be attributed to beta cell dedifferentiation rather than apoptosis;however,the mechanisms by which this occurs remain poorly understood.Our previous study demonstrated that elevation of microRNA-24(miR-24)in a diabetic setting caused beta cell dysfunction and replicative deficiency.In this study,we focused on the role of miR-24 in beta cell apoptosis and dedifferentiation under endoplasmic reticulum(ER)stress conditions.We found that miR-24 overabundance protected beta cells from thapsigargin-induced apoptosis at the cost of accelerating the impairment of glucosestimulated insulin secretion(GSIS)and enhancing the presence of dedifferentiation markers.Ingenuity?Pathway Analysis(IPA)revealed that elevation of miR-24 had an inhibitory effect on XBP1 and ATF4,which are downstream effectors of two key branches of ER stress,by inhibiting its direct target,Irela.Notably,elevated miR-24 initiated another pathway that targeted Mafa and decreased GSIS function in surviving beta cells,thus guiding their dedifferentiation under ER stress conditions.Our results demonstrated that the elevated miR-24,to the utmost extent,preserves beta cell mass by inhibiting apoptosis and inducing dedifFerentiation.This study not only provides a novel mechanism by which miR-24 dominates beta cell turnover under persistent metabolic stress but also offers a therapeutic consideration for treating diabetes by inducing dedifferentiated beta cells to re-differentiation. | Yunxia Zhu Yi Sun Yuncai Zhou Yan Zhang Tao Zhang Yating Li Weiyan You Xiaoai Chang Li Yuan Xiao Han | 2019 | Journal of Molecular Cell Biology2019，11，9： | 9 |
| 5 | Synthesis and Spectrophotometric Studies of 2-(2-Imidazolylazo)-5-Dicthylamino Phenol显示文摘In this paper, 2-(2-imidazolylazo)-5-diethylami phenol (IZAPN) was prepared, theprotonation behaviour and the condition of spectrophotometric determination of cobalt with thisreagent are reported. The results show that the new colour reagent reacts with cobalt to from astable purple red complex (l:3). However, the complex formed could be changed into anotherspecies with stable absorptivity by addition of mineral acid (1+1). The, method is highly selectiveand sensitive and has been applied to the direct determination of cobalt in some alloys withsatisfactory results. | Fu You PAN Chang Hua GE Hua Ding LIANG(Department of Chemistry, Taichou Teachers College, Zhejiang 317000) | 1999 | Chinese Chemical Letters1999，10，11： | 7 |
| 6 | Approach to WTA in air combat using IAFSA-IHS algorithm显示文摘In this paper, a static weapon target assignment(WTA)problem is studied. As a critical problem in cooperative air combat,outcome of WTA directly influences the battle. Along with the cost of weapons rising rapidly, it is indispensable to design a target assignment model that can ensure minimizing targets survivability and weapons consumption simultaneously. Afterwards an algorithm named as improved artificial fish swarm algorithm-improved harmony search algorithm(IAFSA-IHS) is proposed to solve the problem. The effect of the proposed algorithm is demonstrated in numerical simulations, and results show that it performs positively in searching the optimal solution and solving the WTA problem. | LI Zhanwu CHANG Yizhe KOU Yingxin YANG Haiyan XU An LI You | 2018 | Journal of Systems Engineering and Electronics2018，29，3： | 7 |
| 7 | Release of VEGF and BMP9 from injectable alginate based composite hydrogel for treatment of myocardial infarction显示文摘Myocardial infarction(MI)is one of cardiovascular diseases that pose a serious threat to human health.The pathophysiology of MI is complex and contains several sequential phases including blockage of a coronary artery,necrosis of myocardial cells,inflammation,and myocardial fibrosis.Aiming at the treatment of different stages of MI,in this work,an injectable alginate based composite hydrogel is developed to load vascular endothelial active factor(VEGF)and silk fibroin(SF)microspheres containing bone morphogenetic protein 9(BMP9)for releasing VEGF and BMP9 to realize their respective functions.The results of in vitro experiments indicate a rapid initial release of VEGF during the first few days and a relatively slow and sustained release of BMP9 for days,facilitating the formation of blood vessels in the early stage and inhibiting myocardial fibrosis in the long-term stage,respectively.Intramyocardial injection of such composite hydrogel into the infarct border zone of mice MI model via multiple points promotes angiogenesis and reduces the infarction size.Taken together,these results indicate that the dual-release of VEGF and BMP9 from the composite hydrogel results in a collaborative effect on the treatment of MI and improvement of heart function,showing a promising potential for cardiac clinical application. | Yong Wu Tianqi Chang Weiqian Chen Xiaoyu Wang Jingjing Li Yueqiu Chen You Yu Zhenya Shen Qian Yu Yanxia Zhang | 2021 | Bioactive Materials2021，6，2： | 7 |
| 8 | Evaluation of contrast-enhanced computed tomographic colonography in detection of local recurrent colorectal cancer显示文摘瞄准:评估诊断精确性,敏感,在检测颜色的本地复发的提高对比的计算 tomographic colonography 的特性表面的癌症。方法:从 2000 年 1 月到 2004 年 12 月, 434 个病人在以后潜在地药品为侵略颜色的切除术表面的癌症被跟随在上面为从 20 ~ 55 瞬间的经期。为复发显示出充分临床的证据的 434 个病人中的八十个在最后后续期间渲染表面的癌症在这研究被注册。每个病人在一样的天经历了提高对比的计算 tomographic colonography 和结肠镜检查。任何损害,活体检视,在 colonoscopic 期间鉴别检查,立即的复杂并发症和过程的持续时间被记录。提高对比的计算 tomographic colonography 的结果被结肠镜检查,发现的 surgical,和临床的后续比作那些评估。结果:提高对比的计算 tomographic colonography 在检测本地周期性的颜色有 100% , 83% 的特性和 94% 的全面精确性的敏感表面的癌症。结论:常规结肠镜检查和提高对比的 tomographic colonography 能在检测颜色的本地复发补充对方表面的癌症。 | Yau-Tong You Chung-Rong Chang Chien Jeng-Yi Wang Koon-Kwan Ng Jinn-Shiun Chen Reiping Tang Jy-Ming Chiang Chien-Yuh Yeh Pao-Shiu Hsieh | 2006 | World Journal of Gastroenterology2006，12，1： | 7 |
| 9 | Numerical analysis of applying special pavements to solve the frost heave diseases of high-speed railway roadbeds in seasonally frozen ground regions显示文摘The Haerbin-Dalian Passenger Dedicated Line is the first high-speed railway constructed in the seasonally frozen ground regions of northeastern China. Frost heave diseases occurred in the first winter of its operation(between October 2012 and January 2013), and frost heave was observed mainly in the roadbed fills that were considered not susceptible to frost heave. This paper proposes applying two special pavements — black pavement and insulation-black pavement — to improve the thermal regime of the roadbed. Three numerical models of the roadbed temperature field were built based on the field conditions of the Changchun section(D3K692+840 to D3K692+860). The results show that:(1) Compared with cement pavement, black pavement and insulation-black pavement could reduce the freezing index at the roadbed surface by 37% and 64%, respectively, which could influence the maximum frozen depth;(2) the maximum frozen depths under the black pavement and insulation-black pavement were respectively 1.3–1.4 m and 1 m. Compared with cement pavement, they could reduce the maximum frozen depth by 0.4 m and 0.7–0.8 m, respectively, which would reduce the permitted amount of frost heave by 4 mm and 7–8 mm, which would meet the deformation limit established by the Code for Design on Special Subgrade of Railway;(3) the freezing periods of the black pavement and the insulation-black pavement were, respectively, approximately four months and two months. Compared with cement pavement, they could reduce the freezing period by approximately 19 days and 40 days, respectively, and delay the initial freezing time by 9 days and 18 days; and(4) compared with cement pavement, black pavement and black-insulation pavement could reduce the frozen areas of roadbeds in the cold season, which suggests that these two special pavements could provide better thermal stability for roadbeds. | Chang Yuan FuJun Niu QiHao Yu XinBin Wang Lei Guo YanHui You | 2015 | Research in Cold and Arid Regions2015，7，4： | 5 |
| 10 | Glycyrrhetinic acid inhibits ICAM-1 expression via blocking JNK and NF-KB pathways in TNF-α-activated endothelial cells显示文摘 | Ying-ling CHANG Chien-lin CHEN Chao-Lin KUO Bor-chyuan CHEN Jyh-sheng YOU | 2010 | Acta Pharmacologica Sinica2010，31，5： | 5 |
| 11 | Curved copper nanowires-based robust flexible transparent electrodes via all-solution approach显示文摘Curved Cu nanowire (CCN)-based high-performance flexible transparentconductive electrodes (FTCEs) were fabricated via a fully solution-processedapproach, involving synthesis, coating, patterning, welding, and transfer. Eachstep involved an innovative technique for completing the all-solution processes.The high-quality and well-dispersed CCNs were synthesized using a multi-polyolmethod through the synergistic effect of specific polyol reduction. To preciselycontrol the optoelectrical properties of the FTCEs, the CCNs were uniformlycoated on a polyimide (PI) substrate via a simple meniscus-dragging depositionmethod by tuning several coating parameters. We also employed a polyurethane(PU)-stamped patterning method to effectively produce 20/Jm patterns on CCNthin films. The CCN thin films exhibited high electrical performance, which isattributed to the deeply percolated CCN network formed via a solvent-dippedwelding method. Finally, the CCN thin films on the PI substrate were partiallyembedded and transferred to the PU matrix to reduce their surface roughness.Through consecutive processes involving the proposed methods, a highlypercolated CCN thin film on the PU matrix exhibited high optoelectrical perfor-mance (Rs = 53.48 Ω/ at T = 85.71%), excellent mechanical properties (R/Ro 〈1.10 after the 10th repetition of tape peeling or 1,000 bending cycles), and a lowroot-mean-square surface roughness (Rrms = 14.36 nm). | Zhenxing Yin Seung Keun Song Sanghun Cho Duck-Jae You Jeeyoung Yoo Suk Tai Chang Youn Sang Kim | 2017 | Nano Research2017，10，9： | 5 |
| 12 | Association between measures of obesity and colorectal adenoma显示文摘很少研究使用了的背景身体团索引( BMI ), waist-to-hip 比率( WHR )和腰圆周( WC )同时用 BMI 检验了在 colorectal 腺瘤和肥胖之间的协会的力量调查在肥胖和 colorectal adenoma.This 学习之间的协会不仅,而且这研究的 WHR 和 WC.Methods 题目包括了为从2006年1月屏蔽到2008年6月 .Anthropometric 大小的癌症经历了 colonoscopy 的 1322 个无征状的病人,验血 resul 95 信心间隔( CI ), 1.05-1.94 ) .Also ,由 WC 截止的腹的肥胖和最高的 WHR 百分位数组( WHR 0.95 )显著地与 adenoma.Among 被联系然而,仅仅 BMI 有的肥胖的三项措施有在为 BMI 相互地调整以后的腺瘤的一个坚持的协会, WC ,并且 WHR (或, 1.30 ;95 CI, 1.02-1.80;并且 1.49;1.06-2.10,为 WC 和 WHR 调整了,分别地).Conclusion 数据建议一般肥胖与 colorectal 的增加的风险被联系腺瘤。 | KIM You Joung LEE Kang-moon CHUNG Woo Chul PAIK Chang Nyol JUNG Sung Hoon | 2011 | Chinese Medical Journal2011，，22： | 4 |
| 13 | Endomorphin analogues with balanced affinity for bothμ- andδ-opioid receptors显示文摘在位置修改的 endomorphin 和 tripeptides 的类似物分别地, 4 和 3 与各种各样的本氨基丙酸类似物被综合,他们为 opioid 受体的亲密关系被评估。大多数肽展出了有势力受体亲密关系和选择,在他们之中,(Dmt-Pro-Tmp-Tmp-NH2 ) 化合物 7 展出了有势力亲密关系为 - 并且受体(Ki = 0.47 nmol/L, Ki = 1.63 nmol/L ) 。 | Liang Zhang Lei Chang Lei Lei Yu Jin Chun Liu Jia Jia Chen Xiao Wen Li Lawrence H. Lazarus Ting You Li | 2011 | Chinese Chemical Letters2011，22，8： | 4 |
| 14 | A new tetrastilbene from Caragana sinica显示文摘新 tetrastilbene 说出 carasinol D (1 ) 的 A 从锦鸡儿属植物 sinica 的根被孤立。它的结构被分光镜的分析阐明。化合物 1 被催化酸的变换从 carasinol B (2 ) 获得。 | Ke Jun Cheng Da You Ma Guo Xun Yang Chang Qi Hu | 2008 | Chinese Chemical Letters2008，19，6： | 4 |
| 15 | Substrate of complex fractionated atrial electrograms: evidence by pathologic analysis显示文摘 | YOU De-jun CHANG Dong ZHANG Shu-long YANG Dong-hui GAO Lian-jun YIN Xiao-meng CHU Zhen-liang XIA Yun-long WANG Yu-chun DONG Ying-xue YANG Yan-zong | 2012 | Chinese Medical Journal2012，，24： | 3 |
| 16 | Multispectral Plasmon of Anisotropic Core-shell Gold Nanorods@SiO2: Dual-band Absorption Enhancement with Coupling Dye Molecules显示文摘 | CHE Yuping WANG Yang YOU Tingting CHANG Huaiqiu YIN Penggang ZHAI Jin | 2018 | Chemical Research in Chinese Universities2018，34，5： | 3 |
| 17 | A new anti-diabetic sesquiterpenoid from Acorus calamus显示文摘新 sesquiterpenoid, 1,5-guaiane-4,10-diol-6-one (1 ) ,从 Acorus 省藤属的植物的根茎的 70% EtOH 摘录被孤立。结构在分光镜的方法上被决定,特别 2D NMR 技术。1 的绝对配置被它的 ECD 光谱的 TDDFT 量化学药品计算证实。在 HepG2 房间的一个调停胰岛素的葡萄糖消费模型上加重 1 项显示出的有希望的反糖尿病的活动。 | Chang Xin Zhou Di Qiao You You Yan Hao Shu Wu Jian Xia Mo Li She Gan | 2012 | Chinese Chemical Letters2012，23，10： | 3 |
| 18 | Changes in Serum Levels of HBV DNA and Alanine Aminotransferase Determine Risk for Hepatocellular Carcinoma显示文摘 | Chuen–Fei Chen Wen–Chung Lee Hwai–I. Yang Hung–Chuen Chang Chin–Lan Jen Uchenna H. Iloeje Jun Su Chuhsing K. Hsiao Li–Yu Wang San–Lin You Sheng–Nan Lu Chien–Jen Chen | 2011 | Gastroenterology2011，，4： | 3 |
| 19 | Targeting slug-mediated non-canonical activation of c-Met to overcome chemo-resistance in metastatic ovarian cancer cells显示文摘Metastasis-associated drug resistance accounts for high mortality in ovarian cancer and remains to be a major barrier for effective treatment. In this study, SKOV3/T4, a metastatic subpopulation of ovarian cancer SKOV3 cells, was enriched to explore potential interventions against metastaticassociated drug resistance. Quantitative genomic and functional analyses were performed and found that slug was significantly increased in the SKOV3/T4 subpopulation and contributed to the high resistance of SKOV3/T4. Further studies showed that slug activated c-Met in a ligand-independent manner due to elevated levels of fibronectin and provoked integrin α V function, which was confirmed by the significant correlation of slug and p-Met levels in 121 ovarian cancer patient samples. Intriguingly,c-Met inhibitor(s) exhibited greatly enhanced anti-cancer effects in slug-positive ovarian cancer models both in vitro and in vivo. Additionally, IHC analyses revealed that slug levels were highly correlated with reduced survival of ovarian cancer patients. Taken together, this study not only uncovers the critical roles of slug in drug resistance in ovarian cancer but also highlights a promising therapeutic strategy by targeting the noncanonical activation of c-Met in slug-positive ovarian cancer patients with poor prognosis. | Linlin Chang Yan Hu Yingying Fu Tianyi Zhou Jun You Jiamin Du Lin Zheng Ji Cao Meidan Ying Xiaoyang Dai Dan Su Qiaojun He Hong Zhu Bo Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 3 |
| 20 | Comparative study of rendezvous techniques in post-liver transplant biliary stricture显示文摘AIM:To investigate the usefulness of a new rendezvous technique for placing stents using the Kumpe(KMP) catheter in angulated or twisted biliary strictures.METHODS:The rendezvous technique was performed in patients with a biliary stricture after living donor liver transplantation(LDLT) who required the exchange of percutaneous transhepatic biliary drainage catheters for inside stents.The rendezvous technique was performed using a guidewire in 19 patients(guidewire group) and using a KMP catheter in another 19(KMP catheter group).We compared the two groups retrospectively.RESULTS:The baseline characteristics did not differ between the groups.The success rate for placing inside stents was 100% in both groups.A KMP catheter was easier to manipulate than a guidewire.The mean procedure time in the KMP catheter group(1012 s,range:301-2006 s) was shorter than that in the guidewire group(2037 s,range:251-6758 s,P = 0.022).The cumulative probabilities corresponding to the procedure time of the two groups were significantly different(P = 0.008).The factors related to procedure time were the rendezvous technique method,the number of inside stents,the operator,and balloon dilation of the stricture(P < 0.05).In a multivariate analysis,the rendezvous technique method was the only significant factor related to procedure time(P = 0.010).The procedural complications observed included one case of mild acute pancreatitis and one case of acute cholangitis in the guidewire group,and two cases of mild acute pancreatitis in the KMP catheter group.CONCLUSION:The rendezvous technique involving use of the KMP catheter was a fast and safe method for placing inside stents in patients with LDLT biliary stricture that represents a viable alternative to the guidewire rendezvous technique. | Jae Hyuck Chang In Seok Lee Ho Jong Chun Jong Young Choi Seung Kyoo Yoon Dong Goo Kim Young Kyoung You Myung-Gyu Choi Sok Won Han | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
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