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| 1 | A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy显示文摘anti-CTLA-4 抗体由阻止 B7-CTLA-4 相互作用接近否定发信号引起肿瘤拒绝,这被假定。在比临床上有效的 dosing 完成的血浆层次更加高的集中,令人惊讶地, anti-CTLA-4 抗体 Ipilimumab 不由 CTLA-4 也不 CTLA-4 绑定堵住任何一 B7 trans-endocytosis 到使不能调动或联系房间的 B7。因而, Ipilimumab 不从人性化的任何一个 CTLA4 基因在树枝状的房间(DC ) 上增加 B7 (Ctla4 h/h ) 或人的 CD34 + 茎重新组成房间的 NSG 老鼠。在 Ctla4 高效地表示人和老鼠 CTLA4 基因,绑在人的 anti-CTLA-4 抗体然而并非老鼠 CTLA-4 的 h/m 老鼠导致 Treg 弄空和 Fc 受体依赖者肿瘤拒绝。堵住的抗体 L3D10 比得上在引起肿瘤拒绝的非阻塞的 Ipilimumab。显著地,输在人类化期间堵住活动的 L3D10 子孙在导致 Treg 弄空和肿瘤拒绝仍然保持充分能干。有效地在淋巴的器官堵住 CD4 T 细胞激活和 de novo CD8 T 细胞 priming 的 Anti-B7 抗体否定地不影响 Ipilimumab 的 immunotherapeutic 效果。因此,临床上有效的 anti-CTLA-4 mAb 由独立于检查点封锁的机制引起肿瘤拒绝但是依赖于主人 Fc 受体。我们为 CTLA-4 检查点的一个重评价的数据电话封锁假设并且为安全、有效的 anti-CTLA-4 mAbs 的下一代提供新卓见。 | Xuexiang Du Fei Tang Mingyue Liu Juanjuan Su Yan Zhang Wei Wu Martin Devenport Christopher A Lazarski Peng Zhang Xu Wang Peiying Ye Changyu Wang Eugene Hwang Tinghui Zhu Ting Xu Pan Zheng Yang Liu | 2018 | Cell Research2018，28，4： | 25 |
| 2 | The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation显示文摘The immune checkpoint blockade(ICB)targeting on PD-1/PD-L1 has shown remarkable promise in treating cancers.However,the low response rate and frequently observed severe side effects limit its broad benefits.It is partially due to less understanding of the biological regulation of PD-L1.Here,we systematically and comprehensively summarized the regulation of PD-L1 from nuclear chromatin reorganization to extracellular presentation.In PD-L1 and PD-L2 highly expressed cancer cells,a new TAD(topologically associating domain)(chr9:5,400,000-5,600,000)around CD274 and CD273 was discovered,which includes a reported super-enhancer to drive synchronous transcription of PD-L1 and PD-L2.The re-shaped TAD allows transcription factors such as STAT3 and IRF1 recruit to PD-L1 locus in order to guide the expression of PD-L1.After transcription,the PD-L1 is tightly regulated by mi RNAs and RNA-binding proteins via the long 3’UTR.At translational level,PD-L1 protein and its membrane presentation are tightly regulated by post-translational modification such as glycosylation and ubiquitination.In addition,PD-L1 can be secreted via exosome to systematically inhibit immune response.Therefore,fully dissecting the regulation of PD-L1/PD-L2 and thoroughly detecting PD-L1/PD-L2 as well as their regulatory networks will bring more insights in ICB and ICB-based combinational therapy. | Zhiwei Fan Changyue Wu Miaomiao Chen Yongying Jiang Yuanyuan Wu Renfang Mao Yihui Fan | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 4 |
| 3 | Angiogenesis in hepatocellular carcinoma:mechanisms and anti-angiogenic therapies显示文摘Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-associated death worldwide.Angiogenesis,the process of formation of new blood vessels,is required for cancer cells to obtain nutrients and oxygen.HCC is a typical hypervascular solid tumor with an aberrant vascular network and angiogenesis that contribute to its growth,progression,invasion,and metastasis.Current anti-angiogenic therapies target mainly tyrosine kinases,vascular endothelial growth factor receptor(VEGFR),and plateletderived growth factor receptor(PDGFR),and are considered effective strategies for HCC,particularly advanced HCC.However,because the survival benefits conferred by these anti-angiogenic therapies are modest,new anti-angiogenic targets must be identified.Several recent studies have determined the underlying molecular mechanisms,including pro-angiogenic factors secreted by HCC cells,the tumor microenvironment,and cancer stem cells.In this review,we summarize the roles of pro-angiogenic factors;the involvement of endothelial cells,hepatic stellate cells,tumor-associated macrophages,and tumor-associated neutrophils present in the tumor microenvironment;and the regulatory influence of cancer stem cells on angiogenesis in HCC.Furthermore,we discuss some of the clinically approved anti-angiogenic therapies and potential novel therapeutic targets for angiogenesis in HCC.A better understanding of the mechanisms underlying angiogenesis may lead to the development of more optimized anti-angiogenic treatment modalities for HCC. | Changyu Yao Shilun Wu Jian Kong Yiwen Sun Yannan Bai Ruhang Zhu Zhuxin Li Wenbing Sun Lemin Zheng | 2023 | Cancer Biology & Medicine2023，20，1： | 3 |
| 4 | Enhanced in vitro anticancer activity of quercetin mediated by functionalized CdTe QDs显示文摘We report in this study the effects of red-emitting CdTe QDs capped with cysteamine(Cys-CdTe) on the in vitro anticancer activity of the well-known flavenoid quercetin(Qu). Various techniques, including the methylthiazolyldiphenyl-tetrazolium bromide assay, the real-time cell electronic sensing system, the optical and fluorescence imaging, and electrochemical methods have been utilized to study the potential interactions of Cys-CdTe QDs with Qu. The observations demonstrate that the safe-dosage Cys-CdTe QDs can greatly improve the drug uptake and enhance the inhibition efficiency of Qu towards the proliferation of cancer cells such as HepG2 cells. This study implies that Cys-CdTe QDs may be used for cancer therapy and that they exert a synergic anticancer effect when bound to drug molecules. | WU ChunHui SHI LiXin WU ChangYu GUO DaDong SELKE Matthias WANG XueMei | 2014 | Science China Chemistry2014，57，11： | 2 |
| 5 | Discovery of ferrocene-carborane derivatives as novel chemical antimicrobial agents against multidrug-resistant bacteria显示文摘Antimicrobial resistance has now become a very serious global public health problem. New drug discovery and development are urgently needed to combat the growing threat of multidrug-resistant (MDR) bacteria. The aim of this study was to explore the potential application of three ferrocene-carborane derivatives as new promising agents to confront the problem of increasing antibiotic resistance. The results of agar diffusion bioassay, minimal inhibitory concentrations (MIC) testing and time-kill assay illustrate their broad-spectrum antimicrobial activities to both American Type Culture Collection (ATCC) control strains and MDR clinical isolates. It is evident that the relevant antimicrobial properties are all in a dose-dependent manner and gradually transform into a bactericidal effect from a bacteriostatic effect with the increasing of the drug concentration. Furthermore, these ferrocene-carborane derivatives have no/little toxic effect on normal cells like HELF cells and lead to little hemolysis at their MICs. This raises the possibility to develop novel antimicrobial drugs using these new ferrocene carborane derivants. | LI ShuiHong WU ChangYu LV XiaYi TANG Xiao ZHAO XinQing YAN Hong JIANG Hui WANG XueMei | 2012 | Science China Chemistry2012，55，11： | 2 |
| 6 | Superior activity of MnOx-CeO2/TiO2 catalysts for catalytic oxidation of elemental mercury in low flue gas temperatures显示文摘 | Li Hailong Wu Changyu Li Ying | 2012 | Appl Catal B:Environ2012，112，： | 1 |
| 7 | Three-dimensional finite element analysis of deep excavations 显示文摘 | Ou Changyu Chiou D C Wu T S | 1996 | Journal of Geotechnical Engineering1996，122，5： | 1 |
| 8 | Analysis of deep excavation with column type of ground improvement in soft clay 显示文摘 | Ou Changyu Wu Tzong-shiarm Hslk-Hsieh | 1996 | Geotechnlcal Engineering1996，122，9： | 1 |
| 9 | Photoelectrocatalytic oxidation of glutathione based on porous TiO2-Pt nanowhiskers显示文摘 | Chen Guihua Wang Jianling Wu Changyu | 2012 | Langmuir2012，28，12： | 1 |
| 10 | Interleaving phase shifters for critical-mode boost PFC 显示文摘 | TSAI J R WU T F WU Changyu | 2008 | IEEE Transactions on Power Electronics2008，23，3： | 1 |
| 11 | On the frequency domain specification of ESD waveforms显示文摘 | Wu Changyu | 1990 | Journal of Electrostatics1990，24，19： | 1 |
| 12 | Role of Flue Gas Components in Mercury Oxidation over TiO2 Supported MnOx-CeO2 Mixed-oxide at Low Temperature 显示文摘 | LI Hailong WU Changyu LI Ying | 2012 | Jour- nal of Hazardous Materials2012，243，： | 1 |
| 13 | Role of flue gas components in mercury oxidation over TiO2 supported MnO,-CeO2 mixed-oxide at low temperature 显示文摘 | LI Hailong WU Changyu LI Ying | 2012 | Journal of Hazardous Materials2012，243，： | 1 |
| 14 | Removal of elemental mercury from simulated coal-combustion flue gas using a SiO2-TiO2 nanocomposite显示文摘 | Li Ying Murphy P Wu Changyu | 2009 | Fuel Processing Technology2009，148，23： | 1 |
| 15 | A QSAR of the toxicity of amino-benzenes and their structures显示文摘 | Lu Xu Yaping Wu Changyu Hu Hua Li | 2000 | Science in China Series B: Chemistry2000，，2： | 1 |
| 16 | Microwave-assisted preparation of TiO2/activated carbon composite photocatalyst for removal of methanol in humid air streams显示文摘 | Tao Yong Wu Changyu Mazyck D W | 2006 | Industrial and Engineering Chemistry Research2006，45，14： | 1 |
| 17 | Adsorption enhancement mechanisms of silica-titania nanocomposites for elemental mercury vapor removal显示文摘 | Pitoniak E Wu Changyu Mazyck D W | 2005 | Environmental Science and Technology2005，39，5： | 1 |
| 18 | Oxidation and capture of elemental mercury over SiO2 -TiO2 -V20s catalysts in simulated low- rank coal combustion flue gas 显示文摘 | LI Hailong LI Ying WU Changyu | 2011 | Chemical Engineering Journal2011，169，： | 1 |
| 19 | Development of silica/vanadia/titania catalysts for removal of elemental mercury from coal-combustion flue gas显示文摘 | Li Ying Murphy Patrick D Wu Changyu | 2008 | Environ Sci Technol2008，42，14： | 1 |
| 20 | Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrodes显示文摘In this study,we have prepared the blending of gold nanoparticles-multiwalled nanotubes (Au-MCNTs) and then applied the new nanocomposites to modify the glassy carbon electrode (GCE) for highly sensitive detection of the interaction between anticancer drug daunorubicin (DNR) and cancer cells. Electrochemical analysis indicates that the Au-MCNT modified GCE shows high sensitivity and could track the real time response of cancer cells under DNR treatments. Therefore,this new nano-interface and Au-MCNT modified electrode could be explored as a rapid,highly sensitive,and convenient real-time detection strategy in cancer related research and would have prospect in other biomedical applications. | LI QingNing WU XiaoJing ZHAO Juan WU ChangYu WANG XueMei | 2011 | Science China Chemistry2011，54，5： | 1 |
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