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| 1 | Anti-parkinsonian effects of octacosanol in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-treated mice显示文摘Our previous research showed that octacosanol exerted its protective effects in 6-hydroxydopamine-induced Parkinsonian rats. The goal of this study was to investigate whether octacosanol would attenuate neurotoxicity in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)-treated C57BL/6N mice and its potential mechanism. Behavioral tests, tyrosine hydroxylase immunohistochemistry and western blot were used to investigate the effects of octacosanol in a mouse model of Parkinson's disease. Oral administration of octacosanol (100 mg/kg) significantly improved behavioral impairments in mice treated by MPTP and markedly ameliorated morphological appearances of tyrosine hydroxylase-positive neuronal cells in the substantia nigra. Furthermore, octacosanol blocked MPTP-induced phosphorylation of p38MAPK and JNK, but not ERK1/2. These findings implicated that the protective effects afforded by octacosanol might be mediated by blocking the phosphorylation of p38MAPK and JNK on the signal transduction in vivo. Considering its excellent tolerability, octacosanol might be considered as a candidate agent for clinical application in treating Parkinson's disease. | Tao Wang Yanyong Liu Nan Yang Chao Ji Piu Chan Pingping Zuo | 2012 | Neural Regeneration Research2012，7，14： | 7 |
| 2 | Roux-en-Y Reconstruction after Distal Gastrectomy to Reduce Enterogastric Reflux and Helicobacter pylori Infection显示文摘 | De-Chuan Chan Yu-Ming Fan Chih-Kung Lin Cheng-Jueng Chen Ching-Yuan Chen You-Chen Chao | 2007 | Journal of Gastrointestinal Surgery2007，，12： | 4 |
| 3 | Accurate machine learning models based on small dataset of energetic materials through spatial matrix featurization methods显示文摘A large database is desired for machine learning(ML) technology to make accurate predictions of materials physicochemical properties based on their molecular structure.When a large database is not available,the development of proper featurization method based on physicochemical nature of target proprieties can improve the predictive power of ML models with a smaller database.In this work,we show that two new featurization methods,volume occupation spatial matrix and heat contribution spatial matrix,can improve the accuracy in predicting energetic materials' crystal density(ρ_(crystal)) and solid phase enthalpy of formation(H_(f,solid)) using a database containing 451 energetic molecules.Their mean absolute errors are reduced from 0.048 g/cm~3 and 24.67 kcal/mol to 0.035 g/cm~3 and 9.66 kcal/mol,respectively.By leave-one-out-cross-validation,the newly developed ML models can be used to determine the performance of most kinds of energetic materials except cubanes.Our ML models are applied to predict ρ_(crystal) and H_(f,solid) of CHON-based molecules of the 150 million sized PubChem database,and screened out 56 candidates with competitive detonation performance and reasonable chemical structures.With further improvement in future,spatial matrices have the potential of becoming multifunctional ML simulation tools that could provide even better predictions in wider fields of materials science. | Chao Chen Danyang Liu Siyan Deng Lixiang Zhong Serene Hay Yee Chan Shuzhou Li Huey Hoon Hng | 2021 | Journal of Energy Chemistry2021，30，12： | 4 |
| 4 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 5 | Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant显示文摘Dear Editor,Most recently,a new SARS-CoV-2 variant of concern(VOC)Z Omicron(B.1.1.529),was first reported to the World Health Organization(WHO)from South Africa and then quickly spread to many countries,1,2 posing a serious threat to current vaccine prevention and antibody therapeutic strategies.Several studies have reported that the Omicron variant successfully escapes from neutralizing antibodies elicited by COVID-19 vaccines or from COVID-19 convalescent patients. | Shuai Xia Jasper Fuk-Woo Chan Lijue Wang Fanke Jiao Kenn Ka-Heng Chik Hin Chu Qiaoshuai Lan Wei Xu Qian Wang Chao Wang Kwok-Yu ng Yuen Lu Lu Shibo Jiang | 2022 | Cell Research2022，32，4： | 2 |
| 6 | Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation显示文摘Embryo implantation in both humans and rodents is initiated by the attachment of a blastocyst to the uterine epithelium.For blastocyst attachment,the uterine epithelium needs to transform at both the structural and molecular levels first,and then initiate the interaction with trophectoderm.Any perturbation during this process will result in implantation failure or long-term adverse pregnancy outcomes.Endocrine steroid hormones,which function through nuclear receptors,combine with the local molecules produced by the uteri or embryo to facilitate implantation.The insulin-like growth factor(IGF)signaling has been reported to play a vital role during pregnancy.However,its physiological function during implantation remains elusive.This study revealed that mice with conditional deletion of Igflr gene in uteri suffered from subfertility,mainly due to the disturbed uterine receptivity and abnormal embryo implantation.Mechanistically,we uncovered that in response to the nidatory estrogen on D4 of pregnancy,the epithelial IGF1R,stimulated by the stromal cell-produced IGF1,facilitated epithelial STAT3 activation to modulate the epithelial depolarity.Furthermore,embryonic derived IGF2 could activate both the epithelial ERK1/2 and STAT3 signaling through IGF1R,which was critical for the transcription of Cox2 and normal attachment reaction.In brief,our data revealed that epithelial IGF1R was sequentially activated by the uterine stromal IGF1 and embryonic IGF2 to guarantee normal epithelium differentiation during the implantation process. | Chan Zhou Meiying Lv Peike Wang Chuanhui Guo Zhangli Ni Haili Bao Yedong Tang Han Cai Jinhua Lu Wenbo Deng Xiaoyu Yang Guoliang Xia Haibin Wang Chao Wang Shuangbo Kong | 2021 | Journal of Molecular Cell Biology2021，13，9： | 2 |
| 7 | CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development显示文摘尽管 HCO 3− 被知道为早胚胎开发被要求,它的准确角色留下逃犯。这里,我们报导 HCO 3− 在在 preimplantation 胚胎开发期间通过调停 CFTR 的流入调整 miR-125b 表示充当环境暗示。结果证明在 preimplantation 胚胎开发的 HCO 3− 的效果能被介入压制一条 HCO 3−-conducting 隧道的函数, CFTR,由一个特定的禁止者或基因大美人。细胞外的 HCO 3− 的移动或 CFTR 的抑制在 2 个房间阶段老鼠胚胎减少 miR-125b 表示。miR-125b 击倒模仿 HCO 3− 移动和 CFTR 抑制的效果,当 miR-125b 先锋的注射颠倒它时。在人和老鼠胚胎的 miR-125b upregulates p53 串联的 Downregulation。miR-125b 的激活被显示被 sAC/PKA-dependent 调停 NF-κ 的原子 shuttling; B。这些结果在在 preimplantation 胚胎开发期间连接环境 HCO 3− 到 miR-125b 的激活的信号 transduction 揭示了 CFTR 的一个关键角色并且在 miRNAs 的规定显示了离子隧道的重要性。 | Yong Chao Lu Hui Chen Kin Lam Fok Lai Ling Tsang Mei Kuen Yu Xiao Hu Zhang Jing Chen Xiaohua Jiang Yiu Wa Chung Alvin Chun Hang Ma Anskar Yu Hung Leung He Feng Huang Hsiao Chang Chan | 2012 | Cell Research2012，22，10： | 2 |
| 8 | Rapid thermal melted TiO2 nano-particles into ZnO nano-rod and its application for dye sensitized solar cells显示文摘 | Chao C H Chang C L Chan C H | 2010 | Thin Solid Film2010，518，： | 1 |
| 9 | Effect of diallyl trisulfiderich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats显示文摘 | Chan KC Yin MC Chao WJ | 2007 | Food Chem Toxicol2007，45，3： | 1 |
| 10 | Prognostic Significance of Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Angiogenin in Patients With Resectable Hepatocellular Carcinoma After Surgery显示文摘 | Yee Chao MD PhD Chung-Ping Li MD Gar-Yang Chau MD Chih-Ping Chen MD Kuang-Liang King MD Wing-Yiu Lui MD PhD Sang-Hue Yen MD Full-Young Chang MD Wing-Kai Chan MD Shou-Dong Lee MD | 2003 | Annals of Surgical Oncology2003，，4： | 1 |
| 11 | Evaluation of a new inflammatory molecule (triggering receptor expressed on myeloid cells-1) in the diagnosis of pleural effusion显示文摘 | Chan MC Chang KM Chao WC | 2007 | Respirology2007，12，3： | 1 |
| 12 | The mouse formin (Finn) gene: abundant circular RNA transcripts and gene-targeted deletion analysis 显示文摘 | Chao CW Chan DC Kuo A | 1998 | Mol Med1998，4，9： | 1 |
| 13 | Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells显示文摘 | CHAN K S ESPINOSA I CHAO M | 2009 | Proc Natl Acad Sci U S A2009，106，14： | 1 |
| 14 | Predictive value of serial measurements of sTREM-1 in the treatment response of patients with community-acquired pneumonia 显示文摘 | CHAO W C WANG C H CHAN M C | 2007 | J Formos Med Assoc2007，106，3： | 1 |
| 15 | Evaluation of a new inflammatory molecule ( triggering receptor expressed on myeloid cells-1 ) in the diagnosis of pleural effusion显示文摘 | CHAN M C CHANG K M CHAO W C | 2007 | Respirology2007，12，3： | 1 |
| 16 | Evaluation of a new inflam- matory molecule (triggering receptor expressed on myeloid cells-l) in the diagnosis of pleural effusion显示文摘 | Chan MC Chang KM Chao WC | 2007 | Respirology2007，12，3： | 1 |
| 17 | Effect of two-photon absorption on terabertz radiation generated by femtosecond-laser excited photoconductive antennas 显示文摘 | CHAO Kuei-lee CHAN Shan-ang SUNG Hui-lin | 2011 | Optics Express2011，19，25： | 1 |
| 18 | Antioxidant activity of Ganoderma lucidum in acute Ethanol-induced heart toxicity 显示文摘 | Wong K L Chao H H Chan P | 2004 | Phytother Res2004，18，： | 1 |
| 19 | Rapid thermal melted TiO2 nano-particles into ZnO nano-rod and its appli- cation for dye sensitized solar cells显示文摘 | Chao C H Chang C L Chan C H | 2010 | Thin Solid Films2010，518，24： | 1 |
| 20 | Effect of diallyl tris alfide-rich garlic oil on blood coagulation and plasma activity of a nticoagulation factors in rats显示文摘 | Chan K Yin M Chao W | | 0，，03： | 1 |
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