|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | TREM-1 multimerization is essential for its activation on monocytes and neutrophils显示文摘The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune cells.By promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel diseases.However,the molecular events leading to the activation of TREM-1 in innate immune cells remain unknown.Here,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 aggregation.TREM-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and monocytes.In addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its oligomerization.We further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and multimerization.TREM-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 multimerization.These results provide evidence for ligand-induced,receptor-mediated dimerization of TREM-1.Collectively,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils. | Kevin Carrasco Amir Boufenzer Lucie Jolly Helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka Emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay Sebastien Gibot Marc Derive | 2019 | Cellular & Molecular Immunology2019，16，5： | 13 |
| 3 | 瘦素通过醛固酮依赖机制,诱发肥胖雌性小鼠高血压和血管内皮功能障碍显示文摘肥胖是男性与女性心血管病的主要危险因素。然而,肥胖是否通过类似机制触发两性心血管病尚不清楚。在男性中,脂肪细胞因子瘦素通过增强交感神经活性,增加肥胖相关的心血管病。女性可分泌出高于男性3~4倍的瘦素,但未表现出与肥胖相关的较高的交感神经张力。 | 刘莉 叶鹏 Huby AC Otvos L Jr Belin de Chantemèle EJ | 2016 | 中华高血压杂志2016，24，3： | 5 |
| 4 | 动脉瘤性蛛网膜下腔出血患者的重症监护处理:神经危重症监护学会多学科共识会议的推荐意见显示文摘蛛网膜下腔出血(subarachnoidhemorrhage,SAH)是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏,使得治疗方法各异,可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防,很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域,此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验,选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价(GradesofRecommendationsAssessment,DevelopmentandEvaluation,GRADE)系统进行文献回顾,结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见,其制定原则不仅强调研究资料的质量,而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见,即使缺乏高质量的证据。 | Michael N. Diringer Thomas P. Bleck J. Claude Hemphill David Menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez Miriam Tresgiari Ming-Yuan Tseng Mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿 英英(译) | 2013 | 国际脑血管病杂志2013，21，5： | 5 |
| 5 | The influnce of magnitude andduration of crush load on functional recovery of peripheral nerve显示文摘 | Chen LE Seaber AV Urbaniak JR | 1993 | J Reconstr Microsurg1993，9，4： | 1 |
| 6 | Growth and the Class Ⅱ patient: rendering unto Caesar显示文摘 | Johnston LE Jr | 1998 | Semin Orthod1998，4，1： | 1 |
| 7 | Impaired glucose tolerance, type 2 diabetes, and carotid wall thickness: the insulin resistance atherosclerosis study显示文摘 | Wagenknecht LE D'Aagostino RB Jr Haffner SM | 1998 | Diabetes Care1998，21，11： | 1 |
| 8 | Immunolocalization of epidermal growth factor receptors in normal developing human skin 显示文摘 | Nanney LB Stoscheek CM King LE Jr | 1990 | J Invest Dermatol1990，94，： | 1 |
| 9 | Impaired glucose tolerance, type 2 diabetes, and carotid wall thickness: the insulin resistance atherosclerosls study显示文摘 | Wagenknecht LE D'Agostino RB Jr Haffner SM | 1998 | Diabetes Care1998，21，： | 1 |
| 10 | Endocrine screening methods workshop report : detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms 显示文摘 | Gray LE Jr Kelce WR Wiese T | 1997 | Repred Toxicol1997，11，5： | 1 |
| 11 | Gemcitabine as a single-agent treatment for ovarian cancer显示文摘 | Fowler WC Jr Van Le L | 2003 | Gynecol Oncol2003，90，22： | 1 |
| 12 | Throe-dimensional computational fluid dynamics modeling of alterations in coronary wall shear stress produced by 8tent implantation显示文摘 | LaDisa JF Jr Galer I Olson LE | 2003 | Ann Biomed Eng2003，31，8： | 1 |
| 13 | Plasma levobupivacaine concentrations following scalp block in patients undergoing awake cra-niotomy显示文摘 | Costello TG Cormack JR Mather LE | 2005 | British journal of anaesthesia2005，94，6： | 1 |
| 14 | Alterations in regional vascular geometry produced by theoretical stent implantation influence distributions of wall shear stress: analysis of a curved coronary artery using 3D computational fluid dynamics modeling显示文摘 | LaDisa JF Jr Olson LE Douglas HA | 2006 | Biomed Eng Online2006，5，： | 1 |
| 15 | The method of sperm col- lection significantly influences sperm motion parameter following ethare dimethane sulphomate administration in the rat 显示文摘 | Kinefelter GR Gray LE Jr Suarez JD | 1991 | Re- prod Toxicol1991，5，1： | 1 |
| 16 | Ultrasonographic characterization of cervical lymphadenopathy in chronic autoimmune thyroidi- tis 显示文摘 | JR S B TUTI'LE R M | 2013 | Thyroid Official Journal of the American Thyroid Association2013，23，2： | 1 |
| 17 | Urinary indices during dehydration, exercise, and rehydration 显示文摘 | Armstrong LE Soto JA Hacker Jr | 1998 | Sport Nutr & Exerc Metab1998，8，4： | 1 |
| 18 | Overview of doeetaxel (Taxotere)/eisplatin combination in non-small cell lung cancer 显示文摘 | Le Chevalier T Berille J Zalcberg JR | 1999 | Semin Oneol1999，26，311： | 1 |
| 19 | Helicobacter pylori and gastric cancer factors that modulate disease risk显示文摘 | Wroblewski LE Peek RM Jr Wilson KT | 2010 | Clin Microbiol Rev2010，23，4： | 1 |
| 20 | Follicle-stimulating hormone receptor-mediated uptake of 45 Ca^2+ by proteoliposomes and cultured rat Sertoli cells: evidence for involvement of voltage-activated and voltage-independent calcium channels显示文摘 | Grasso P Reiehert LE Jr | 1989 | Endocrinology1989，125，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员