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| 1 | Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis显示文摘AIM:To assess expression of matrix metalloproteinases 2(MMP2)and MMP9 in gastric cancer,superficial gastritis and normal mucosa,and to measure metalloproteinase activity.METHODS:MMP2 and MMP9 mRNA expression was determined by quantitative real-time polymerase chain reaction.Normalization was carried out using three different factors.Proteins were analyzed by quantitative gelatin zymography(qGZ).RESULTS:18S ribosomal RNA(18SRNA)was very highly expressed,while hypoxanthine ribosyltransferase-1(HPRT-1)was moderately expressed.MMP2 was highly expressed,while MMP9 was not detected or lowly expressed in normal tissues,moderately or highly expressed in gastritis and highly expressed in cancer.Relative expression of 18SRNA and HPRT-1 showed no significant differences.Significant differences in MMP2 and MMP9 were found between cancer and normal tissue,but not between gastritis and normal tissue.Absolute quantification of MMP9 echoed this pattern,but differential expression of MMP2 proved conflictive.Analysis by qGZ indicated significant differences between cancer and normal tissue in MMP-2,total MMP-9,250 and 110 kDa bands.CONCLUSION:MMP9 expression is enhanced in gastric cancer compared to normal mucosa;interpretation of differential expression of MMP2 is difficult to establish. | Clara Luz Sampieri Sol de la Pea Mariana Ochoa-Lara Roberto Zenteno-Cuevas Kenneth León-Córdoba | 2010 | World Journal of Gastroenterology2010，16，12： | 46 |
| 2 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 3 | Age-speci?cincidence of Alzheimer's disease in a community population显示文摘 | Hebert LE Scherr PA Beckett LA | 1995 | Jama1995，273，： | 1 |
| 4 | Effect of health insur- ance on the use and provision of maternal health services and maternal and neonatal health outcomes: A systematic review显示文摘 | I Comfort AB Peterson LA Hatt LE | 2013 | J Health Popul Nutr2013，31，4： | 1 |
| 5 | Pain-temperature lelation in the application of local anaesthesia显示文摘 | Perula LA Fiaja LE | 1993 | Rr J plast surg1993，46，1： | 1 |
| 6 | Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study 显示文摘 | Morrison AC Bare LA Chambless LE | 2007 | Am J Epidemiol2007，166，1： | 1 |
| 7 | The Etiology of Maleness in XX Men 显示文摘 | le la Chapelle A | 1981 | Hum Genet1981，58，： | 1 |
| 8 | Detection of human cytomegalovirus in normal and neoplastic breast epithelium 显示文摘 | Harkins LE Matlaf LA Soroceanu L | 2010 | Herpesviridae2010，1，1： | 1 |
| 9 | Production and Target- ing of the BruceUa abortusAntigen L7/L12 in theLactococcus lactis:a First Step towards Food-Grade Live Vaccines against Brucellosis显示文摘 | Ribeiro LA Azevedo V Le Loir Y | 2002 | Applied and Environmental Microbiology2002，68，2： | 1 |
| 10 | Do condoms prevent genital HPV infecti- on, oxternal genital warts, or cervical neoplasia? A meta- analysis显示文摘 | Manhart LE Koutsky LA | 2002 | Sex Transm Dis2002，29，： | 1 |
| 11 | Histone deacetylase inhibi- tion-mediated differentiation of RGC-5 cells and interaction with survival显示文摘 | Schwechter BR Millet LE Levin LA | 2007 | Invest Ophthalmol Vis Sci2007，48，6： | 1 |
| 12 | Enhancing compliance with Medicare guidelines for surgical infection prevention,experience with a cross-disciplinary quality improvement team显示文摘 | McCahill LE Ahern JW Gruppi LA etal | 2007 | Arch Surg2007，142，4： | 1 |
| 13 | Changes in squalene and sterols associated with olive maturation显示文摘 | A. Fernández-Cuesta L. León L. Velasco R. De la Rosa | 2013 | Food Research International2013，，2： | 1 |
| 14 | BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells显示文摘 | Stephanie Beurlet Nader Omidvar Petra Gorombei Patricia Krief Carole Le Pogam Niclas Setterblad Pierre de la Grange Christophe Leboeuf Anne Janin Maria-Elena Noguera Florence Hervatin Laure Sarda-Mantel Marina Konopleva Michael Andreeff Andrea W. Tu Alice | 2013 | Blood2013，，16： | 1 |
| 15 | 'Natural' human leukocyte antigen antibodies found in nonalloimmunized healthy males显示文摘 | Morales-Buenrostro LE Terasaki PI Marino-Vazquez LA | | 0，，08： | 1 |
| 16 | Detection of human cytomegalovirus in normal and neoplastic breast epithelium 显示文摘 | Harkins LE Matlaf LA Soroceanu L Klemm K Britt WJ Wang W Bland KI Cobbs CS | 2010 | Herpesviridae2010，1，1： | 1 |
| 17 | Bioactive peptides in amaranth (Amaranthus hypochondriacus) seed显示文摘 | Silva-Sa'nchez C de la Rosa A P León-Galván M F | 2008 | J Agric Food Chem2008，56，4： | 1 |
| 18 | Radiographic,CT,and MR imaging features of dedifferentiated chondrosarcomas:a retrospective review of 174 de novo cases显示文摘 | Littrell LA Wenger DE Wold LE | 2004 | Radiographics2004，24，5： | 1 |
| 19 | Gallbladder cancer: can ultrasonography evaluate extent of disease? 显示文摘 | Bach AM Loring LA Hann LE | 1998 | J Ultrasound Med1998，17，5： | 1 |
| 20 | Abdominal wall defects: two - versus three - dimensional uhrasonographic diagnosis 显示文摘 | Bonilla - Musoles F Machado LE Bailao LA | 2001 | J Ultrasound Med2001，20，4： | 1 |
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