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| 1 | Melanoma:Molecular genetics,metastasis,targeted therapies,immunotherapies,and therapeutic resistance显示文摘Cutaneous melanoma is a common cancer and cases have steadily increased since the mid 70s.For some patients,early diagnosis and surgical removal of melanomas is lifesaving,while other patients typically turn to molecular targeted therapies and immunotherapies as treatment options.Easy sampling of melanomas allows the scientific community to identify the most prevalent mutations that initiate melanoma such as the BRAF,NRAS,and TERT genes,some of which can be therapeutically targeted.Though initially effective,many tumors acquire resistance to the targeted therapies demonstrating the need to investigate compensatory pathways.Immunotherapies represent an alternative to molecular targeted therapies.However,inter-tumoral immune cell populations dictate initial therapeutic response and even tumors that responded to treatment develop resistance in the long term.As the protocol for combination therapies develop,so will our scientific understanding of the many pathways at play in the progression of melanoma.The future direction of the field may be to find a molecule that connects all of the pathways.Meanwhile,noncoding RNAs have been shown to play important roles in melanoma development and progression.Studying noncoding RNAs may help us to understand how resistance e both primary and acquired e develops;ultimately allow us to harness the true potential of current therapies.This review will cover the basic structure of the skin,the mutations and pathways responsible for transforming melanocytes into melanomas,the process by which melanomas metastasize,targeted therapeutics,and the potential that noncoding RNAs have as a prognostic and treatment tool. | William Wagstaff Rimel N.Mwamba Karina Grullon Mikhayla Armstrong Piao Zhao Bryce Hendren-Santiago Kevin H.Qin Alexander J.Li Daniel A.Hu Andrew Youssef Russell R.Reid Hue H.Luu Le Shen Tong-Chuan He Rex C.Haydon | 2022 | Genes & Diseases2022，9，6： | 2 |
| 2 | Adenocarcinoma of the cecum: natural history and clinical patterns of recurrence following radical surgery 显示文摘 | Tong D Russell AH Dawson LE | 1983 | Int J Radiat Oncol Biol Phys1983，9，： | 1 |
| 3 | Hormonal control of puebertal spermatogenesis显示文摘 | Ager LE Nequin LG | 1987 | Endorcrinology1987，120，4： | 1 |
| 4 | The seasonal cycle in coupled ocean-atmosphere general circulation models显示文摘 | C. Covey A. Abe-Ouchi G. J. Boer B. A. Boville U. Cubasch L. Fairhead G. M. Flato H. Gordon E. Guilyardi X. Jiang T. C. Johns H. Le Treut G. Madec G. A. Meehl R. Miller A. Noda S. B. Power E. Roeckner G. Russell E. K. Schneider R. J. Stouffer L. Terray J. | 2000 | Climate Dynamics (-)2000，，10： | 1 |
| 5 | Microwave-heated pyrolysis of waste automotive engine oil: Influence of operation parameters on the yield, composition, and fuel properties ofpyrolysisoil显示文摘 | Lam Su Shiung Russell Alan D Lee Chem Leing | 2012 | Fuel2012，92，： | 1 |
| 6 | Hormonal control of pubertal spermatogenesis 显示文摘 | Russell LD Alger LE Nequin LG | 1987 | Endocrinology1987，120，4： | 1 |
| 7 | Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium 显示文摘 | Russell RG Lasorella A Dettin LE | 2004 | Cancer Res2004，64，20： | 1 |
| 8 | A case of pubertas praecox (macrogenitosomia praecox) in a boy associated with a tumor in the floor of the third ventricle显示文摘 | Le Marquand HS Russell DS | 1934 | Berk Hosp Rep1934，3，： | 1 |
| 9 | Comparative effects of various classes of mouse interferon on macrophage activation for tumor cell killing 显示文摘 | Pece JL Russell SW Le Blanc P | 1985 | J Immunol1985，，134： | 1 |
| 10 | The precision of estimating the total energy demand: implications for the determination of the accumulated oxygen deficit 显示文摘 | RUSSELL A P LE ROSSIGNOL P F LOS K | 2000 | Exerc Physiol2000，3，： | 1 |
| 11 | Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease显示文摘 | Doucet M Russell A P Le'ger B | | 0，，03： | 1 |
| 12 | A case of pubertas praecox (maerogenitosomia praecox) in a boy associated with a tumor in the floor of the third ventricle显示文摘 | Le Marquand HS Russell DS | 1934 | Berk Hosp Rep1934，3，： | 1 |
| 13 | Id2 drives differentiation and suppiesses tumor formation in the intestinal epithelium显示文摘 | Russell RG Lasorella A Dettin LE | 2004 | Cancer Res2004，64，20： | 1 |
| 14 | A case of pubertas praecox (macrogenitosomia praecox) in a boy associated with a tumour in the floor of the third ventricle显示文摘 | Le Marquand HS Russell DS | 1934 | Roy Berks Hosp Rep1934，27，3： | 1 |
| 15 | Peroxisome proliferator-activated receptor δ and γ agonists differentially alter tumor differentiation and progression during mammary carcinogenesis 显示文摘 | YIN Y RUSSELL RG DETTIN LE | 2005 | Cancer Res2005，65，9： | 1 |
| 16 | Phylogeny and a new tribal classification of Opiliaceae (Santalales) based on molecular and morphological evidence显示文摘 | Chi-Toan Le Bing Liu Russell L. Barrett Li-Min Lu Jun Wen Zhi-Duan Chen | 2018 | Journal of Systematics and Evolution2018，56，1： | 1 |
| 17 | Physiological ischemia/reperfusion phenomena and their relation to endogenous melatonin production显示文摘 | Dun-Xian Tan Lucien C. Manchester Rosa M. Sainz Juan C. Mayo Josefa León Russel J. Reiter | 2005 | Endocrine2005，，2： | 1 |
| 18 | Primary cutaneous small vessel vasculitis: approach to diagnosis and treatment显示文摘 | Russell JP Gibson LE | 2006 | Int J Dermatol2006，45，1： | 1 |
| 19 | Thickness and structure of high beta magnetopause current layer显示文摘 | Le G Russell C T | 1994 | Geophysical Research Letters1994，21，23： | 1 |
| 20 | Microwave-heated pyrolysis of waste automotive engine oil:Influence of operation parameters on the yield,composition,and fuel properties of pyrolysis oil显示文摘 | Su Shiung Lam Alan D Russell Chern Leing Lee | 2012 | Fuel2012，，92： | 1 |
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