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| 1 | Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung显示文摘 | Le Cras TD Tyler RC Horan MP | 1998 | J Clin Invest1998，101，4： | 1 |
| 2 | Elevated CSF cytokines in the Jarisch-Herxheimer reaction of general paresis 显示文摘 | Davis LE Oyer R Tyler KL | 2013 | JAMA Neurol2013，70，8： | 1 |
| 3 | Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung显示文摘 | Le Cras TD Tyler RC Horan MP | 1998 | J Clin Invest1998，101，4： | 1 |
| 4 | Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung显示文摘 | Le CT D Tyler R C Horan M P | 1998 | Journal Clinical Investigation1998，101，4： | 1 |
| 5 | The dose response of caudal morphine in children显示文摘 | Krane EJ Tyler DC Jacobson LE | 1989 | Anesthesiology1989，71，1： | 1 |
| 6 | 单次甲烷呼气试验判断甲烷浓度高低的阈值选择:来自一个大型北美氢气-甲烷-二氧化碳呼气试验数据库的结果显示文摘背景:甲烷-氢气呼气试验,是在加入碳水化合物底物后,每15-20 min间隔收集一次呼气标本,共10个样本,对这10个样本中甲烷和氢气浓度进行检测。采用该法判断氢气浓度的升高需要频繁的样本检测,而且氢气浓度升高otepad多发生于呼气试验后期;相较之下,甲烷浓度一般在底物加入前即可升高。如果将甲烷浓度作为呼气试验的主要目标,单次甲烷检测(例如收集禁食一晚后单个时间点的呼气样本,无需加入底物)或许足矣。方法:我们分析了11,674例连续检测的十样本乳酸呼气试验结果,这些病例来自于过去一年美国各州,所有呼气标本均在Commonwealth实验室(Salem,MA,USA)进行检测。将北美共识指南(NAC)的呼气试验标准作为参考标准。结果:参照NAC标准,该数据库病例的甲烷总体阳性率粗略为18.9%,校正后为20.4%。判断甲烷浓度高低的最佳阈值为≥4 ppm,其灵敏度为94.5%(可信区间:93.5%~95.4%),特异度为95.0%(可信区间:94.6%~95.5%)。采用校正因子(以5%的CO_(2)作为分子)进行校正后,有0.7%的高甲烷浓度重新判定为低浓度,2.1%的低甲烷浓度被判定为高浓度。结论:无论是基于本数据库所得出的≥4 ppm还是另一项单中心研究所描述的≥5 ppm作为呼气试验中甲烷基线浓度的阈值,用于判断传统十样本乳酸呼气试验检测小肠细菌过度生长时所诊断的“甲烷阳性”,都具有很高的准确性。 | Klaus Gottlieb Chenxiong Le Vince Wacher Joe Sliman Christine Cruz Tyler Porter Stephen Carter | 2017 | Gastroenterology Report2017，5，3： | 1 |
| 7 | Cardiac cine MR-imaging at 3T:FLASH vs SSFP显示文摘 | Tyler DJ Hudsmith LE Petersen SE | | 0，，5： | 1 |
| 8 | Selection of a cut-off for high-and low-methane producers using a spot-methane breath test:results from a large north American dataset of hydrogen,methane and carbon dioxide measurements in breath显示文摘Gastroenterol Rep(Oxf).2017 doi:10.1093/gastro/gow048.The authors wish to inform the reader that any references to‘confidential interval’throughout the paper have been corrected to‘confidence interval’.The paper has now been corrected online. | Klaus Gottlieb Chenxiong Le Vince Wacher Joe Sliman Christine Cruz Tyler Porter Stephen Carter | 2018 | Gastroenterology Report2018，6，3： | 0 |
| 9 | Multispectral light scattering endoscopic imaging of esophageal precancer显示文摘Esophageal adenocarcinoma is the most rapidly growing cancer in America.Although the prognosis after diagnosis is unfavorable,the chance of a successful outcome increases tremendously if detected early while the lesion is still dysplastic.Unfortunately,the present standard-of-care,endoscopic surveillance,has major limitations,since dysplasia is invisible,often focal,and systematic biopsies typically sample less than one percent of the esophageal lining and therefore easily miss malignancies.To solve this problem we developed a multispectral light scattering endoscopic imaging system.It surveys the entire esophageal lining and accurately detects subcellular dysplastic changes.The system combines light scattering spectroscopy,which detects and identifies invisible dysplastic sites by analyzing light scattered from epithelial cells,with rapid scanning of the entire esophageal lining using a collimated broadband light beam delivered by an endoscopically compatible fiber optic probe.Here we report the results of the first comprehensive multispectral imaging study,conducted as part of routine endoscopic procedures performed on patients with suspected dysplasia.In a double-blind study that characterized the system’s ability to serve as a screening tool,55 out of 57 patients were diagnosed correctly.In addition,a smaller double-blind comparison of the multispectral data in 24 patients with subsequent pathology at locations where 411 biopsies were collected yielded an accuracy of 90%in detecting individual locations of dysplasia,demonstrating the capability of this method to serve as a guide for biopsy. | Le Qiu Ram Chuttani Douglas K Pleskow Vladimir Turzhitsky Umar Khan Yuri N Zakharov Lei Zhang Tyler M Berzin Eric U Yee Mandeep S Sawhney Yunping Li Edward Vitkin Jeffrey D Goldsmith Irving Itzkan Lev T Perelman | 2017 | Light(Science & Applications)2017，6，1： | 0 |
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