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| 1 | 肥胖患者的冠状动脉微血管功能障碍和心血管病风险显示文摘全世界有〉5亿的肥胖人群,其心血管病风险增加的病理生理机制是复杂的,并且可能涉及脂肪细胞相关因子的过量分泌,导致血管氧化应激增加,神经激素活性上调,以及低度全身炎症,可能导致交感神经系统激活增加,血管张力改变,冠状动脉微血管功能障碍(coronary microvascular dysfunction, CMD) 。 | Bajaj NS Osborne MT Gupta A Tavakkoli A Bravo PE Vita T Bibbo CF Hainer J Dorbala S Blankstein R Bhatt DL Di Carli MF Taqueti VR 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 11 |
| 2 | 视神经脊髓炎IgG刺激原代培养大鼠星形胶质细胞免疫反应显示文摘视神经脊髓炎(NMO)主要累及星形胶质细胞,导致中枢神经系统炎症、脱髓鞘和组织损伤。脑内病灶常高表达水通道蛋白4(AQP4),AQP4被认为是NMO血清IgG的抗原目标。根据NMO的可逆性及对NMO病灶演变特点的分析,笔者推测NMO IgG可能诱导了星形胶质细胞的动态免疫过程。培养原代大鼠星形胶质细胞,加入从NMO患者血清中提取或纯化的IgG,星形胶质细胞出现炎性增殖,同时基因表达出现与之匹配的明显变化。且星形胶质细胞反应因子脂质运载蛋白-2、多种趋化因子、细胞因子、应激反应因子的表达均增加。而在培养的原代星形胶质细胞中加入从正常对照者血清中提取的IgG则无上述变化。此星形胶质细胞的反应还与疾病种类相关。从复发缓解型多发硬化、Sj觟gren's或系统性红斑狼疮患者血清中提取的IgG加入培养的原代星形胶质细胞中也不能导致上述变化。笔者推测是NMO IgG与AQP4结合,导致星形胶质细胞出现炎症反应,并出现基因在转录和翻译水平的相应变化。抑制星形胶质细胞的炎症反应可能有助于减少星形胶质细胞增殖,缓解NMO病灶的发展。 | Howe CL Kaptzan T Magaa SM Ayers-Ringler JR LaFrance-Corey RG Lucchinetti CF | 2014 | 神经损伤与功能重建2014，9，3： | 4 |
| 3 | Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes显示文摘In neonates, persistent hyperinsulinemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-de- pendent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody 2/3 genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus Ⅱ has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be con- sidered. | A Raffel M Anlauf SB Hosch M Krausch T Henopp J Bauersfeld R Klofat D Bach CF Eisenberger G Klppel WT Knoefel | 2006 | World Journal of Gastroenterology2006，12，44： | 3 |
| 4 | A Phase I study of TNP-470 administered to patients with advanced squamouse cell cancer of the cervix显示文摘 | Kudelka AP Levy T Verschraegen CF | 1997 | Clin Cancer Res1997，3，： | 1 |
| 5 | Pharmacokinetics of paclitaxel and metabolism in a randomized comparative study in platinum-pretreated ovarian cancer patients显示文摘 | Huizing Anther CF | 1993 | J Clin Oncol1993，11，11： | 1 |
| 6 | Inhaled drugs for the prevent and treatmen of bronchopulmonary dysplasia显示文摘 | Pantalitschka T Poets CF | 2006 | Pediatr Pulmonol2006，41，8： | 1 |
| 7 | Antifungal prophy laxis in lung transplantation a world wide survey显示文摘 | Neoh CF Snell G1 Kotsimbos T | 2011 | Am J Transplant2011，11，2： | 1 |
| 8 | Physiologic concentrations of glucose regulate fatty acid synthase activity in HepG2 cells by mediating fatty acid synthase mRNA stability显示文摘 | Semenkovich CF Coleman T Groforth R | 1993 | Biol Chem1993，268，10： | 1 |
| 9 | Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities 显示文摘 | Schloss PD Westcott SL Ryabin T Hall JR Hartmann M Hollister EB Lesniewski RA Oakley BB Parks DH Robinson CJ Sahl JW Stres B Thallinger GG Van Horn DJ Weber CF | 2009 | Appl Environ Microbiol2009，75，23： | 1 |
| 10 | Absence of peroxi- some proliferator-activated receptor-alpha abolishes hypertension and attenuates atherosclerosis in the Tsukuba hypertensive mouse 显示文摘 | Tordjman KM Semenkovich CF Coleman T | 2007 | Hy- pertension2007，50，5： | 1 |
| 11 | Fracture resistance of different partial-coverage ceramic molar restorations:An in vitro investigation显示文摘 | Stappert CF Art W Gerds T | 2006 | J Am Dent Assoc2006，137，4： | 1 |
| 12 | Polyethylene Crosslinking and Water Treeing 显示文摘 | Florin C Gisele T Jean CF | 2001 | Polymer2001，，42： | 1 |
| 13 | Downregulation of glutamine synthetase via GLAST suppression induces retinal axonal swelling in a rat ex vivo hydrostatic pressure model 显示文摘 | Ishikawa M Yoshitomi T Zormuski CF Izumi Y | 2011 | Invest Ophtlmlmol Vis Sci2011，52，9： | 1 |
| 14 | Plasminogen activator inhibitor - 1 suppresses endogenous fibrinolysis in a caninemodel of pulmonary embolism 显示文摘 | Reily CF Fujita T Hutzelmann JE etal | 1991 | Circulation1991，84，1： | 1 |
| 15 | Pharmacokinetics and pharmacodynamics of the effects of oral and intravenous administrations of dofetilide on ventricular repolarization显示文摘 | Funck BC Morell T | 1995 | Clin Pharmacol Ther1995，57，： | 1 |
| 16 | Charaeterisation of patients with primary biliary eirrhosis responding to long term ursodeoxyeholie aeid treatment显示文摘 | Leusehner M Dietrich CF You T | 2000 | Gut2000，46，1： | 1 |
| 17 | Andreasent O Pro-traction of the maxil Lofacial complex显示文摘 | Stappert CF Ozden U Gerds T | 2005 | J PresthetDent2005，94，2： | 1 |
| 18 | UGT1A1 gene polymorphisms and the toxicities of FOLFIRI in Chinese Han patients with gastrointestinal Cancer 显示文摘 | Zhou CF Ma T Su Y | 2013 | Anticancer Agents Med Chem2013，13，2： | 1 |
| 19 | Loss of epithelial membrane protein-2 expression confers an independent prognosticator in gallbladder carcinoma显示文摘 | Li CF Chen L T Lin CY | 2013 | Biomarkers Genomic Med2013，52，： | 1 |
| 20 | ThePittsburgh sleep quality index: a new instrument or psychiatricand research 显示文摘 | Buysse DJ Reynolds CF Monk T H | 1989 | Psychiatry Research1989，28，2： | 1 |
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