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| 1 | Experimental study of“Tong Xia”purgative method in ameliorating lung injury in acute necrotizing pancreatitis显示文摘AIM To investigate the role of tumor necrosisfactor(TNF)in lung injury during acutenecrotizing pancreatitis(ANP),and thetherapeutic effect of'Tong Xia'purgativemethod in minimizing the severity of lung injury.METHODS Fourteen canines were randomlydivided into 3 groups:the'Tong Xia'treatmentgroup(n = 5)using Dachengqitang;salinecontrol group(n = 5),and the sham operationgroup(n = 4).TNF activity in serum and inbronchoalveolar lavage fluid(BALF),the serumendotoxin levels were measured,and theseverity of lung injury evaluated.RESULTS Elevation of TNF activity was moreprominent in BALF than in serum.TNF activity inserum at 6 and 12 hours and in BALI:wassignificantly decreased in the'Tong Xia'treatment group than in the saline control one(q=21.11,q=12.07,q=9.03,respectively,P<0.01)and the lung injury was significantlyalleviated at 12 hours as compared with that inthe saline group,manifested as amelioration otthe lung wet/ dry weight ratio,decrease inprotein concentration and neutrophils count inBALF,and improvement of pulmonaryinflammatory changes.A positive correlationwas demonstrated between serum TNF activity and endotoxin level.CONCLUSION Hypersecretion of TNF is shownto be one of the major causes of lung injuryduring ANP;'Tong Xia'purgative method couldalleviate the degree of lung injury mediated byTNF. | Xia Q Jiang JM Gong X Chen GY Li L Huang ZW | 2000 | World Journal of Gastroenterology2000，6，1： | 31 |
| 2 | The expression and clinical significance of CD44v in human gastric cancers显示文摘INTRODUCTIONCD44 was originally implicated as a'homing'receptor directing the migration of recirculatinglymphocytes.CD44 expression has beenconfirmed not only in lymphocytes but also in awide variety of epithelial tissues.It is considered asan important cell adhesion molecule for cell to cellinteractions.Molecular cloning and analysis | Chen GY Wang DR | 2000 | World Journal of Gastroenterology2000，6，1： | 22 |
| 3 | The innate immune receptor Nodl protects the intestine from inflammation-induced tumorigenesis 显示文摘 | Chen GY Shaw MH Redondo G | 2008 | Cancer Res2008，68，10： | 1 |
| 4 | Inhibition of excitatory synap tictransmission by trans-resveratrol in rat hippocampus显示文摘 | Gao ZB Chen XQ Hu GY | 2006 | Brain Res2006，1111，1： | 1 |
| 5 | Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma 显示文摘 | Yang MH Chen CL Chau GY | 2009 | Hepatology2009，50，5： | 1 |
| 6 | Activity of compounds from Chinese herbal medicine Rhodiola kirilowii(Regel)Maxim against HCV NS3 serine protease显示文摘 | Zuo GY Li ZQ Chen LR | 2007 | Antiviral Research2007，76，1： | 1 |
| 7 | Association betweenthe brain - derived neurotrophic factor ( BDNF) gene andSchizophrenia in the Chinese population 显示文摘 | Chen QY Chen Q Feng GY | 2006 | NeuroscienceLetters2006，39，： | 1 |
| 8 | Temporospatial expression of MMPs/TIMPs in kidney during ageing of rat显示文摘 | Chen XM Li F Cai GY | 2003 | Nephrol Dial Transplant2003，18，3： | 1 |
| 9 | The prognostic role of a gene signature from tumorigenic breast-cancer cells显示文摘 | Liu R Wang X Chen GY | | 0，，03： | 1 |
| 10 | Hypoxemia and autonomic nerv- ous dysfunction in patients with chronie obstructive pulmonary disease显示文摘 | Chen WL Chen GY Kuo CD | 2006 | Respir Med2006，100，： | 1 |
| 11 | A muhicenter study of the as- sociation of serum uric acid, serum creatinine, and diuretic use in hypertensive patients 显示文摘 | Lin CS Hung YJ Chen GY | 2011 | Int J C ardiol2011，148，3： | 1 |
| 12 | Cost comparison between hand-assisted laparoscopic colectomy and open colectomy显示文摘 | Liu Z Wang GY Chen YG | 2012 | J Laparoendosc Adv Surg Tech A2012，22，3： | 1 |
| 13 | Proteomic analy- sis of rat retina after methanol intoxication显示文摘 | Chen JM Zhu GY Xia WT | 2012 | Toxi- cology2012，293，13： | 1 |
| 14 | Prevalence of and Risk Fac- tors for Type 2 Diabetes Mellitus in Hyperlipidemia in China 显示文摘 | Chen GY Li L Dai F | 2015 | Med Sci Monit2015，21，： | 1 |
| 15 | Simultaneous quantification of anti-microbial agents for multidrug-resistant bacterial infections in human plasma by ultra-high-pressure liquid chromatography-tandem mass spectrometry显示文摘 | Tsai IL Sun HY Chen GY | 2013 | Talanta2013，116，： | 1 |
| 16 | Immunoglobulin A nephropathy in China: progress and challenges显示文摘 | Cai GY Chen XM | 2009 | Am J Nephrol2009，30，3： | 1 |
| 17 | Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD - 95 after transient brain ischemia 显示文摘 | Chen M Hou XY Zhang GY | 2003 | Neurosci Lett2003，339，1： | 1 |
| 18 | Morphological and molecularidentification of two strains of dermatophytes 显示文摘 | CHEN L SHI GY WANG MM | 2013 | J Huazhong UnivSci Technolog Med Sci2013，33，6： | 1 |
| 19 | Sterile inflammation: sensing and reacting to damage显示文摘 | Chen GY Nufiez G | 2010 | Nat Rev Immunol2010，10，12： | 1 |
| 20 | The interactions of epigallo-catechin-3-gallate with human whole saliva and parotid saliva显示文摘 | Yao JW Lin CJ Chen GY | 2010 | Arch Oral Biol2010，55，7： | 1 |
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