|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 2 | The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein.显示文摘 | Chen TY Liu PH Ruan CT Chiu L Kung FL | 2006 | 中国生物学文摘2006，20，9： | 4 |
| 3 | Prognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patients显示文摘AIM To investigate the associations of the genetic polymor-phisms of vascular endothelial growth factor A(VEGF-A)-1498C>T and-634G>C, with the survival of patients with colorectal cancer(CRC). METHODS A prospective cohort consisting of 131 Brazilians patients consecutively operated on with a curative intention as a result of sporadic colorectal carcinoma was studied. DNA was extracted from peripheral blood and its amplification and allelic discrimination for each genetic polymorphism was performed using the technique of polymerase chain reaction(PCR) in real-time. The real-time PCR technique was used to identify the VEGF-A-1498C>T(rs833031) and-634G>C(rs2010963) polymorphisms. Genotyping was validated for VEGF-A-1498C>T polymorphism in 129 patients and for VEGF-A-634G>C polymorphism in 118 patients. The analysis of association between categorical variables was performed using logistic regression, survival by Kaplan-Meier method and multivariate analysis by the Cox regression method. RESULTS In the univariate analysis there was a significant association(OR = 0.32; P = 0.048) between genotype CC of the VEGF-A-1498C>T polymorphism and the presence of CRC liver metastasis. There was no association between VEGF-A-1498C>T polymorphism and VEGF-A-634G>C polymorphism with further clinical or anatomopathologic variables. The genotype CC of the VEGF-A-1498C>T polymorphism was significantly correlated with the 5-year survival(P = 0.032), but not significant difference(P = 0.27) was obtained with the VEGF-A-634G>C polymorphism with the 5-year survival in the univariate analysis. The genotype CT(HR = 2.79) and CC(HR = 4.67) of the polymorphism VEGF-A-1498C>T and the genotype CC(HR = 3.76) of the polymorphism VEGF-A-634C>G acted as an independent prognostic factor for the risk of death in CRC patients. CONCLUSION The CT and CC genotypes of the VEGF-A-1498C>T and the CC genotype of the VEGF-A-634C>G polymorphisms are prognostic factors of survival in Brazilians patients with sporadic colorectal carcinoma. | Gilmar Ferreira do Espírito Santo Bianca Borsatto Galera Elisabeth Carmen Duarte Elisabeth Suchi Chen Lenuce Azis Amilcar Sabino Damazo Gabriela Tognini Saba Flávia de Sousa Gehrke Ismael Dale Cotrim Guerreiro da Silva Jaques Waisberg | 2017 | World Journal of Gastrointestinal Oncology2017，9，2： | 4 |
| 4 | Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery显示文摘 | Lin YH Mi FL Chen CT | 2007 | Biomacromolecules2007，8，1： | 1 |
| 5 | Porous chitosan microsphere for controlling the antigen release of newcastle disease vaccine preparation of antigen-absorbed microsphere and in vitro release显示文摘 | Mi FL Shyu SS Chen CT | 1999 | Biomaterials1999，20，17： | 1 |
| 6 | Glioblastoma cells de- ficient in DNA-dependent protein kinase are resistant to cell death显示文摘 | Chen GG Sin FL Leung BC | 2005 | J Cell Physiol2005，203，1： | 1 |
| 7 | Induction of apoptosis in prostate cancer cell lines by a flavonoid,baicalin显示文摘 | Chan FL Choi HL Chen ZY | 2000 | Cancer Lett2000，160，： | 1 |
| 8 | Change of serum growth factors in infants with isolated ventricular defect undergoing surgical repair显示文摘 | Tsai TP Yu JM Wu YL Huang CY Chen FL | 2002 | Ann Whorac Surg2002，73，6： | 1 |
| 9 | Luteolin attenuates the pulmonary inflammatory response involves abilities of antioxidation and inhibition of MAPK and NFκB pathways in mice with endotoxin-induced acute lung injury显示文摘 | Kuo MY Liao MF Chen FL | 2011 | Food Chem Toxicol2011，49，10： | 1 |
| 10 | Possible involvement of nitric oxide in the progression of diabetic retinopathy 显示文摘 | Tsai DC Chiou SH Lee FL Chou CK Chen S J Peng CH | 2003 | Ophthalmologica2003，217，5： | 1 |
| 11 | Debonding analysis of FRP-concrete interface between two balanced adjacent flexural cracks in plated beams显示文摘 | Chen FL Qiao PZ | | 0，，13： | 1 |
| 12 | Activation of astrocytes in the anterior cingulate cortex contributes to the affective component of pain in an inflammatory pain model 显示文摘 | Chen FL Dong YL Zhang ZJ | 2012 | Brain Res Bull2012，87，： | 1 |
| 13 | A novel pH-sensitive hydrogelcomposed ofN, O-carboxymethyl chitosan and alginate crosslinked by genipin for protein drug delivery 显示文摘 | Chen SC Wu YC Mi FL | 2004 | J Controlled Release2004，96，2： | 1 |
| 14 | Induction of apopto- sis in prostate cancer cell lines by a favonoid, baicalin 显示文摘 | Chan FL Choi HL Chen ZY | 2000 | Cancer Lett2000，160，2： | 1 |
| 15 | Simultaneous determination of ephedr al- kaloids in traditional chinese medicines by high performance liquid chromatomatogr chromatography显示文摘 | Chen Y Li XG Chen FL | 2012 | Acta Chromatographica2012，1，24： | 1 |
| 16 | Polymorphisms of DNA repair genes XPD,XRCC1,and OGG1,and lung adenocarcinoma susceptibility in Chinese population显示文摘 | Ouyang FD Yang FL Chen HC | 2013 | Tumour Biol2013，34，5： | 1 |
| 17 | The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase显示文摘 | WANG Y CHAN FL CHEN S | 2005 | Life Sci2005，77，1： | 1 |
| 18 | Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin显示文摘 | CHOI HL CHEN ZY | 2000 | Cancer Lett2000，160，2： | 1 |
| 19 | Current knowledge and attitudes about organ donation and transplantation among Chinese university students 显示文摘 | Chen JX Zhang TM Lim FL | 2006 | Transplant Proc2006，38，9： | 1 |
| 20 | B-type natriuretic peptide:beyond a diagnostic显示文摘 | Martin FL Chen HH Cataliotti A | 2008 | Heart Fail Clin2008，4，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员