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| 1 | Tenofovir rescue therapy for chronic hepatitis B patients after multiple treatment failures显示文摘AIM:To evaluate the efficacy and safety of tenofovir disoproxil fumarate(TDF) for chronic hepatitis B(CHB) patients after multiple failures.METHODS:A total of 29 CHB patients who had a suboptimal response or developed resistance to two or more previous nucleoside/nucleotide analogue(NA) treatments were included.Study subjects were treated with TDF alone(n = 13) or in combination with lamivudine(LAM,n = 12) or entecavir(ETV,n = 4) for ≥ 6 mo.Complete virologic response(CVR) was defined as an achievement of serum hepatitis B virus(HBV) DNA level ≤ 60 IU/mL by real-time polymerase chain reaction method during treatment.Safety assessment was based on serum creatinine and phosphorus level.Eleven patients had histories of LAM and adefovir dipivoxil(ADV) treatment and 18 patients were exposed to LAM,ADV,and ETV.Twenty-seven patients(93.1%) were hepatitis B e antigen(HBeAg) positive and the mean value of the baseline serum HBV DNA level was 5.5 log IU/mL ± 1.7 log IU/mL.The median treatment duration was 16 mo(range 7 to 29 mo).RESULTS:All the patients had been treated with LAM and developed genotypic and phenotypic resistance to it.Resistance to ADV was present in 7 patients and 10 subjects had a resistance to ETV.One patient had a resistance to both ADV and ETV.The cumulative probabilities of CVR at 12 and 24 mo of TDF containing treatment regimen calculated by the Kaplan Meier method were 86.2% and 96.6%,respectively.Although one patient failed to achieve CVR,serum HBV DNA level decreased by 3.9 log IU/mL from the baseline and the last serum HBV DNA level during treatment was 85 IU/mL,achieving near CVR.No patients in this study showed viral breakthrough or primary non-response during the follow-up period.The cumulative probability of HBeAg clearance in the 27 HBeAg positive patients was 7.4%,12%,and 27% at 6,12,and 18 mo of treatment,respectively.Treatment efficacy of TDF containing regimen was not statistically different according to the presence of specific HBV mutations.History of prior exposure to specific antiviral agents did not make a difference to treatment outcome.Treatment efficacy of TDF was not affected by combination therapy with LAM or ETV.No patient developed renal toxicity and no cases of hypophosphatemia associated with TDF therapy were observed.There were no other adverse events related to TDF therapy observed in the study subjects.CONCLUSION:TDF can be an effective and safe rescue therapy in CHB patients after multiple NA therapy failures. | Yu Jin Kim Dong Hyun Sinn Geum-Youn Gwak Moon Seok Choi Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Joon Hyeok Lee | 2012 | World Journal of Gastroenterology2012，18，47： | 16 |
| 2 | Milan criteria are useful predictors for favorable outcomes in hepatocellular carcinoma patients undergoing liver transplantation after transarterial chemoembolization显示文摘AIM: To evaluate whether the Milan criteria are useful in patients with hepatocellular carcinoma (HCC) who received transarterial chemoembolization (TACE) before liver transplantation (LT). METHODS: Thirty-six HCC patients who fulfilled the Milan criteria after having received TACE and subsequently underwent LT were included (TACE + LT group) in the study. As controls, 21 patients who also met the Milan criteria and underwent LT without prior treatment were selected (LT group). Post-LT clinical outcomes, such as HCC recurrence, survival rate, and histologic features of explanted livers, were compared between the two groups. RESULTS: Baseline characteristics were not different between the two groups. Pre-LT maximal tumor diameter in TACE + LT group was similar to that of LT group (2.0 ± 0.6 cm vs 2.3 ± 0.9 cm; P = 0.10). Post-LT histologic findings also revealed similar maximal tumor diameter in the two groups (2.4 ± 1.4 cm vs 2.3 ± 0.9 cm; P = 0.70). Explanted livers showed similar incidence of unfavorable pathologic features. The morality within 60 d after transplantation was not different between the two groups (8.3% vs 9.5%; P = 0.99). Post-LT 5-year survival rate (57% vs 74%; P = 0.70) and cumulative recurrence rate (8.3% vs 4.8%; P = 0.90) were not significantly different between the two groups. CONCLUSION: The Milan criteria are still a useful selec- tion criteria showing favorable outcomes in HCC patientsreceiving TACE before LT. | Do Young Kim Moon Seok Choi Joon Hyoek Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Sung Wook Shin Sung Wook Choo Young Soo Do Jong Chul Rhee | 2006 | World Journal of Gastroenterology2006，12，43： | 4 |
| 3 | Clinicopathologic features and prognosis of combined hepatocellular cholangiocarcinoma显示文摘 | Kwang Cheol Koh Hyuk Lee Moon Seok Choi Joon Hyoek Lee Seung Woon Paik Byung Chul Yoo Jong Chul Rhee Jae Won Cho Cheol Keun Park Hong Joo Kim | 2005 | The American Journal of Surgery2005，，1： | 2 |
| 4 | Percutaneous radiofrequency ablation for early-stage hepatocellular carcinoma as a first-line treatment: long-term results and prognostic factors in a large single-institution series显示文摘 | Dongil Choi Hyo K. Lim Hyunchul Rhim Young-sun Kim Won Jae Lee Seung Woon Paik Kwang Cheol Koh Joon Hyoek Lee Moon Seok Choi Byung Chul Yoo | 2007 | European Radiology2007，，3： | 2 |
| 5 | HBV DNA and HBsAg Levels as Risk Predictors of Early and Late Recurrence after Curative Resection of HBV-related Hepatocellular Carcinoma显示文摘 | Won Sohn Yong-Han Paik Jong Man Kim Choon Hyuk Kwon Jae Won Joh Ju Yeon Cho Geum-Youn Gwak Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2014 | Annals of Surgical Oncology2014，，7： | 2 |
| 6 | Percutaneous Radiofrequency Ablation for Recurrent Hepatocellular Carcinoma After Hepatectomy: Long-term Results and Prognostic Factors显示文摘 | Dongil Choi MD Hyo K. Lim MD Hyunchul Rhim MD Young-sun Kim MD Byung Chul Yoo MD Seung Woon Paik MD Jae-Won Joh MD Cheol Keun Park MD | 2007 | Annals of Surgical Oncology2007，，8： | 1 |
| 7 | Can rebamipide and proton pump inhibitor combination therapy promote the healing of endoscopic submucosal dissection–induced ulcers? A randomized, prospective, multicenter study显示文摘 | Woon Geon Shin Sung Jung Kim Min Ho Choi Kyoung Oh Kim Hyun Joo Jang Cheol Hee Park Il Hyun Baek Kyung Ho Kim Gwang Ho Baik Sea Hyub Kae Jong Hyeok Kim Hak Yang Kim | 2012 | Gastrointestinal Endoscopy2012，，4： | 1 |
| 8 | Seroprevalence of anti-HAV among patients with chronic viral liver disease显示文摘AIM:To investigate the current seroprevalence of hepatitis A virus(HAV) antibodies in patients with chronic viral liver disease in Korea.We also tried to identify the factors affecting the prevalence of HAV antibodies. METHODS:We performed an analysis of the clinical records of 986 patients(mean age:49±9 years,714 males/272 females) with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection who had undergone HAV antibody testing between January 2008 and December 2009.RESULTS:The overall prevalence of IgG anti-HAV was 86.61%(854/986) in patients with chronic liver disease and was 88.13%(869/986) in age-and gendermatched patients from the Center for Health Promotion.The anti-HAV prevalence was 80.04%(405/506) in patients with chronic hepatitis B,86.96%(20/23) in patients with chronic hepatitis C,93.78%(422/450) in patients with HBV related liver cirrhosis,and 100%(7/7) in patients with HCV related liver cirrhosis.The anti-HAV prevalence according to the decade of age was as follows:20s(6.67%) ,30s(50.86%) ,40s(92.29%) ,50s(97.77%) ,and 60s(100%) .The antiHAV prevalence was significantly higher in patients older than 40 years compared with that in patients younger than 40 years of age.Multivariable analysis showed that age≥40 years,female gender and metropolitan cities as the place of residence were independent risk factors for IgG anti-HAV seropositivity. CONCLUSION:Most Korean patients with chronic liver disease and who are above 40 years of age have already been exposed to hepatitis A virus. | Hyun Chin Cho Seung Woon Paik Yu Jin Kim Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Byung Chul Yoo Hee Jung Son Seon Woo Kim | 2011 | World Journal of Gastroenterology2011，17，2： | 1 |
| 9 | Percutaneous Radiofrequency Ablation for Recurrent Hepatocellular Carcinoma After Hepatectomy: Long-term Results and Prognostic Factors显示文摘 | Dongil Choi MD Hyo K. Lim MD Hyunchul Rhim MD Young-sun Kim MD Byung Chul Yoo MD Seung Woon Paik MD Jae-Won Joh MD Cheol Keun Park MD | 2007 | Annals of Surgical Oncology2007，，8： | 1 |
| 10 | Direct Synthesis of Molybdenum Phosphide Nanorods on Silicon Using Graphene at the Heterointerface for Efficient Photoelectrochemical Water Reduction显示文摘Transition metal phosphides(TMPs)and transition metal dichalcogenides(TMDs)have been widely investigated as photoelectrochemical(PEC)catalysts for hydrogen evolution reaction(HER).Using high-temperature processes to get crystallized compounds with large-area uniformity,it is still challenging to directly synthesize these catalysts on silicon photocathodes due to chemical incompatibility at the heterointerface.Here,a graphene interlayer is applied between p-Si and MoP nanorods to enable fully engineered interfaces without forming a metallic secondary compound that absorbs a parasitic light and provides an inefficient electron path for hydrogen evolution.Furthermore,the graphene facilitates the photogenerated electrons to rapidly transfer by creating Mo-O-C covalent bondings and energetically favorable band bending.With a bridging role of graphene,numerous active sites and anti-reflectance of MoP nanorods lead to significantly improved PEC-HER performance with a high photocurrent density of 21.8 mA cm−2 at 0 V versus RHE and high stability.Besides,low dependence on pH and temperature is observed with MoP nanorods incorporated photocathodes,which is desirable for practical use as a part of PEC cells.These results indicate that the direct synthesis of TMPs and TMDs enabled by graphene interlayer is a new promising way to fabricate Si-based photocathodes with high-quality interfaces and superior HER performance. | Sang Eon Jun Seokhoon Choi Shinyoung Choi Tae Hyung Lee Changyeon Kim Jin Wook Yang Woon‑Oh Choe In‑Hyuk Im Cheol‑Joo Kim Ho Won Jang | 2021 | Nano-Micro Letters2021，13，5： | 1 |
| 11 | Combined Hepatectomy and Radiofrequency Ablation for Multifocal Hepatocellular Carcinomas: Long-term Follow-up Results and Prognostic Factors显示文摘 | Dongil Choi MD Hyo K. Lim MD Jae-Won Joh MD Sung-Joo Kim MD Min Ju Kim MD Hyunchul Rhim MD Young-sun Kim MD Byung Chul Yoo MD Seung Woon Paik MD Cheol Keun Park MD | 2007 | Annals of Surgical Oncology2007，，12： | 1 |
| 12 | Percutaneous Radiofrequency Ablation for Recurrent Hepatocellular Carcinoma After Hepatectomy: Long-term Results and Prognostic Factors显示文摘 | Dongil Choi MD Hyo K. Lim MD Hyunchul Rhim MD Young-sun Kim MD Byung Chul Yoo MD Seung Woon Paik MD Jae-Won Joh MD Cheol Keun Park MD | 2007 | Annals of Surgical Oncology2007，，8： | 1 |
| 13 | Clinical parameters predictive of outcomes in sorafenib‐treated patients with advanced hepatocellular carcinoma显示文摘 | Ju‐Yeon Cho Yong‐Han Paik Ho Yeong Lim Young Gon Kim Hyo Keun Lim Yang Won Min Geum‐Youn Gwak Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2013 | Liver Int2013，，6： | 1 |
| 14 | Synthesis of olivine LiFePO4 cathode materials by mechanical alloying using iron(Ⅲ) raw material显示文摘 | Cheol Woo Kim Moon Hee Lee Woon Tae Jeong | 2005 | Journal of Power Sources2005，146，： | 1 |
| 15 | An increased rectal maximum tolerable volume and long anal canal are associated with poor short-term response to biofeedback therapy for patients with anismus with decreased bowel frequency and normal colonic transit time显示文摘 | Poong-Lyul Rhee Moon Seok Choi Young Ho Kim Hee Jung Son Jae Jun Kim Kwang Cheol Koh Seung Woon Paik Jong Chul Rhee Kyoo Wan Choi | 2000 | Diseases of the Colon & Rectum2000，，： | 1 |
| 16 | Has Peptic Ulcer Disease Changed During the Past Ten Years in Korea? A Prospective Multi-center Study显示文摘 | Hyun Joo Jang Min Ho Choi Woon Geon Shin Kyung Ho Kim Yong Woo Chung Kyoung Oh Kim Cheol Hee Park Il Hyun Baek Kwang Ho Baik Sea Hyub Kae Hak Yang Kim | 2008 | Digestive Diseases and Sciences2008，，6： | 1 |
| 17 | HPV-18 is a poor prognostic factor, unlike the HPV viral load, in patients with stage IB–IIA cervical cancer undergoing radical hysterectomy显示文摘 | Woo Dae Kang Cheol Hong Kim Moon Kyoung Cho Jong Woon Kim Hye Yon Cho Yoon Ha Kim Ho Sun Choi Seok Mo Kim | 2011 | Gynecologic Oncology2011，，3： | 1 |
| 18 | Mortality after surgery in patients with liver cirrhosis: comparison of Child–Turcotte–Pugh, MELD and MELDNa score显示文摘 | Hyun Chin Cho Han Young Jung Dong Hyun Sinn Moon Seok Choi Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Seon Woo Kim Joon Hyeok Lee | 2011 | European Journal of Gastroenterology & Hepatology2011，，1： | 1 |
| 19 | Characteristics and prevalence of intrapulmonary shunt detected by contrast echocardiography with harmonic imaging in liver transplant candidates显示文摘 | Byung Jin Kim Sang-Chol Lee Seung Woo Park Moon-Suk Choi Kwang Cheol Koh Seung Woon Paik Sang Hoon Lee Kyung Pyo Hong Jeong Euy Park Jung Don Seo | 2004 | The American Journal of Cardiology2004，，4： | 1 |
| 20 | Steatosis Among Living Liver Donors Without Evidence of Fatty Liver on Ultrasonography: Potential Implications for Preoperative Liver Biopsy显示文摘 | Joon Seong Ahn Dong Hyun Sinn Geum-Youn Gwak Jong Man Kim Choon Hyuck Kwon Jae Won Joh Yong-Han Paik Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2013 | Transplantation Journal2013，，11： | 1 |
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