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| 1 | Modeling cardiac arrest and resuscitation in the domestic pig显示文摘Cardiac arrest remains a leading cause of death and permanent disability worldwide. Although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury inflicted on the internal organs, especially the brain. Cardiac arrest initiates a complex cellular injury cascade encompassing reactive oxygen and nitrogen species, Ca2+ overload, ATP depletion, pro- and anti-apoptotic proteins, mitochondrial dysfunction, and neuronal glutamate excitotoxity, which injures and kills cells, compromises function of internal organs and ignites a destructive systemic inflammatory response. The sheer complexity and scope of this cascade challenges the development of experimental models of and effective treatments for cardiac arrest. Many experimental animal preparations have been developed to decipher the mechanisms of damage to vital internal organs following cardiac arrest and cardiopulmonary resuscitation(CPR), and to develop treatments to interrupt the lethal injury cascades. Porcine models of cardiac arrest and resuscitation offer several important advantages over other species, and outcomes in this large animal are readily translated to the clinical setting. This review summarizes porcine cardiac arrest-CPR models reported in the literature, describes clinically relevant phenomena observed during cardiac arrest and resuscitation in pigs, and discusses numerous methodological considerations in modeling cardiac arrest/CPR. Collectively, published reports show the domestic pig to be a suitable large animal model of cardiac arrest which is responsive to CPR, defibrillatory countershocks and medications, and yields extensive information to foster advances in clinical treatment of cardiac arrest. | Brandon H Cherry Anh Q Nguyen Roger A Hollrah Albert H Olivencia-Yurvati Robert T Mallet | 2015 | World Journal of Critical Care Medicine2015，4，1： | 2 |
| 2 | Physical mechanisms of celldamage in microcarrier cell culture bioreactors显示文摘 | CHERRY R S ELEFT HERIOS T P | 1988 | Biotechnol and Bioeng1988，32，10： | 1 |
| 3 | Groundwater contamination: Pump - and - treat remediation 显示文摘 | Mackay D M Cherry T A | 1989 | Environment Science and Technology1989，23，6： | 1 |
| 4 | Effect of cage design on growth of transplanted Asian clams:implications for assessing bivalve responses in streams显示文摘 | Cherry D S Merricks T C | 2004 | Environmental Monitoring and Assessment2004，96，13： | 1 |
| 5 | Bioassess- ment of an appalachian headwater stream influenced by an abandoned arsenic mine显示文摘 | Valenti T W Chaffin J L Cherry D S | 2005 | Archives of Envi ronmental Contamination and Toxicology2005，49，： | 1 |
| 6 | Sustainable coccidiosis control in poultry production: the role of live vaccines 显示文摘 | Chapman H D Cherry T E Danforth H D | 2002 | Int J Parasitol2002，32，5： | 1 |
| 7 | Sustained coccidiosis control in poultry production:the role of live vaccines显示文摘 | Chapman H D Cherry T E Danforth H D | 2002 | Int J Parasitol2002，32，： | 1 |
| 8 | Sustainable coccidiosis control in poultry production: the role of live vaccines 显示文摘 | Chapman H D Cherry T E Danforth H D | 2002 | Int J Parasitol2002，32，5： | 1 |
| 9 | Sustainable coccidiosis control in poultry production: the role of live vaccines显示文摘 | Chapman H D Cherry T E Danforth H D | 2002 | Int J Parasitol2002，32，5： | 1 |
| 10 | Progress and challenges in enzyme development for biomass utilization 显示文摘 | Merino S T Cherry J | 2007 | Adv Biochem Eng Biotechnol2007，108，： | 1 |
| 11 | Polarisation behaviour of steel bar samples in concrete in seawater--Part 1 :Experimental measurement of polarisation curves of steel in concrete显示文摘 | Chang Z T Cherry B Marosszeky M | 2008 | Corrosion Science2008，50，2： | 1 |
| 12 | Effects of an aqueous extract from the leaves of Chromolaena odorata on the proliferation of human ke- ratinocytes and on the immigration in an in vitro model of reepithelializa- tion显示文摘 | PHAN T T HUGHES M A CHERRY G W | 2001 | Wound Repair Regen2001，9，4： | 1 |
| 13 | The pressure quench formation of rapakivi texture显示文摘 | Cherry M E Trembath L T | 1978 | Contributions to Mineralogy and Petrology1978，68，： | 1 |
| 14 | Sus- tainable coccidiosis control in poultry production: the role of live vaccines显示文摘 | Chapman H D Cherry T E Donforth H D | 2002 | Int J Parasitol2002，32，5： | 1 |
| 15 | Experimental manipulation of intraclutch variation in the great reed warbler shows no effect on rejection of parasitic eggs显示文摘 | Karcza Z Moskat C Cherry MI Kisbenedek T | | 0，，： | 1 |
| 16 | Sustainable coccidiosis contorl in poultry production: the role of live vaccines 显示文摘 | Chapman H D Cherry T E Danforth H D | 2002 | Int J Parasitol2002，32，： | 1 |
| 17 | Clinical definitions of pertussis: summary of a Global Pettussis Initiative roundtable meeting, February 2011 显示文摘 | Cherry JD Tan T Wirsing von Knig CH | 2012 | Clin Infect Dis2012，54，12： | 1 |
| 18 | Effects of an aqueous extract from the leaves of Chromolaena odorata on the proliferation of human keratinocytes and on their migration in an in vitro model of reepithelialization 显示文摘 | PHAN T T HUGHES M A CHERRY G W | 2001 | Wound Repair Regen2001，9，4： | 1 |
| 19 | Sensitivity to genotoxic effects of bleomycin in humans: possible relationship to environmental carcinogenesis 显示文摘 | Hsu T C Johnston D A Cherry L M | 1989 | Int J Cancer1989，43，3： | 1 |
| 20 | Cisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregation显示文摘 | CHERRY S M HUNT P A HASSOLD T J | 2004 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis2004，564，2： | 1 |
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