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| 1 | Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice显示文摘Pathological bone loss is caused by an imbalance between bone formation and resorption.The bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone remodeling.However,the relevant functions of HIF-2α are not well understood.Here,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and osteoclasts.In vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of Traf6.In addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor cells.Experiments performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this crosstalk.HIF-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated osteoclastogenesis.Collectively,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis. | Sun Young Lee Ka Hyon Park Hyung-Gu Yu Eunbyul Kook Won-Hyun Song Gyuseok Lee Jeong-Tae Koh Hong-In Shin Je-Yong Choi Yun Hyun Huh Je-Hwang Ryu | 2019 | Bone Research2019，7，2： | 5 |
| 2 | Endometrial response to conceptus-derived estrogen and interleukin-1β at the time of implantation in pigs显示文摘The establishment of pregnancy is a complex process that requires a well-coordinated interaction between the implanting conceptus and the maternal uterus. In pigs, the conceptus undergoes dramatic morphological and functional changes at the time of implantation and introduces various factors, including estrogens and cytokines,interleukin-1β2(IL1 B2), interferon-γ(IFNG), and IFN-δ(IFND), into the uterine lumen. In response to ovarian steroid hormones and conceptus-derived factors, the uterine endometrium becomes receptive to the implanting conceptus by changing its expression of cell adhesion molecules, secretory activity, and immune response. Conceptus-derived estrogens act as a signal for maternal recognition of pregnancy by changing the direction of prostaglandin(PG) F2αfrom the uterine vasculature to the uterine lumen. Estrogens also induce the expression of many endometrial genes,including genes related to growth factors, the synthesis and transport of PGs, and immunity. IL1 B2, a pro-inflammatory cytokine, is produced by the elongating conceptus. The direct effect of IL1 B2 on endometrial function is not fully understood. IL1 B activates the expression of endometrial genes, including the genes involved in IL1 B signaling and PG synthesis and transport. In addition, estrogen or IL1 B stimulates endometrial expression of IFN signaling molecules,suggesting that estrogen and IL1 B act cooperatively in priming the endometrial function of conceptus-produced IFNG and IFND that, in turn, modulate endometrial immune response during early pregnancy. This review addresses information about maternal-conceptus interactions with respect to endometrial gene expression in response to conceptus-derived factors, focusing on the roles of estrogen and IL1 B during early pregnancy in pigs. | Hakhyun Ka Heewon Seo Yohan Choi Inkyu Yoo Jisoo Han | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 5 |
| 3 | Primary CD56+ nasal-type T/natural killer-cell subcutaneous panniculitic lymphoma: presentation as haemophagocytic syndrome 显示文摘 | Jang KA Choi JH Sung KJ | 1999 | Br J Dermatol1999，141，4： | 1 |
| 4 | A lingin-sepcific peroxidase in tobacco whose antisense suppression leads to vascular tissue modification 显示文摘 | Blee KA Choi JW O’Connell AP Schuch W Lewis NG Bolwell GP | 2003 | Phytochemistry2003，64，1： | 1 |
| 5 | Little evidence of transdifferentiation of bone marrow-clerived cells into pancreatic beta cells显示文摘 | Choi JB Uchino H Zuma KA | 2003 | Diabetologia2003，46，： | 1 |
| 6 | The use of motor mapping to aid resection of eloquent gliomas显示文摘 | Choi BD Mehta AI Batich KA | 2012 | Neurosurg Clin N Am2012，23，2： | 1 |
| 7 | High-pressure hand injection injuries caused by dry cleaning solvents:case reports,review of the literature,and treatment guidelines显示文摘 | Gutowski KA Chu J Choi M | 2003 | Plast Reconstr Surg2003，111，1： | 1 |
| 8 | Idiopathic eruptive macular pigmentation: report of 10 cases显示文摘 | Jang KA Choi JH Sung KS | 2001 | J Am Acad Dermatol2001，44，2： | 1 |
| 9 | Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear显示文摘 | Choi DC Maguschak KA Ye K | 2010 | Proc Natl Acad Sci U S A2010，107，6： | 1 |
| 10 | Unusual renal cell carcinomas a pictorial essay 显示文摘 | KIN KA CHOI JW PARK CM | 2006 | Abdominal Imaging2006，31，2： | 1 |
| 11 | Low serum vitamin D is associated with high risk of diabetes in Korean adults显示文摘 | Choi HS Kim KA Lim CY | 2011 | J Nutri2011，141，8： | 1 |
| 12 | Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear显示文摘 | Choi DC Maguschak KA Ye K | 2010 | PNAS2010，107，6： | 1 |
| 13 | SLC26A4 genotypes and phenotypes associat- ed with enlargement of the vestibular aqueduct 显示文摘 | Ito T Choi BY King KA | 2011 | Cell Physiol Biochem2011，28，3： | 1 |
| 14 | Detection of recurrent hepato- cellular carcinoma on post-operative surveillance: comparison of MDCT and gadoxetic acid-enhanced MRI显示文摘 | Kim KA Kim M J Choi JY | 2014 | Abdom Imaging2014，39，： | 1 |
| 15 | Hyperkeratosis lenticularis perstans (Flegel's disease): histologic, immunohistochemical, and ultrastructural features in a case显示文摘 | Jang KA Choi JH Sung KJ | 1999 | Am J Dermatopathol1999，21，4： | 1 |
| 16 | Effects of the monomeric, oligomeric, and fibrillar Abeta (42) peptides on the proliferation and differentiation of adult neural stem cells from subventricular zone显示文摘 | Heo C Chang KA Choi HS | 2007 | J Neurochem2007，102，2： | 1 |
| 17 | Effect of Spa spring water on cyto- kine expression in human keratinocyte HaCaT cells and on differenti- ation of CD4+ T cells 显示文摘 | Lee HP Choi Y J Cho KA | 2012 | Ann Dermatol2012，24，3： | 1 |
| 18 | Effects of combined radiofrequency radiation exposure on levels of reactive oxygen species in neuronal cells显示文摘 | Kang KA Lee HC Lee JJ Hong MN Park MJ Lee YS Choi HD Kim N Ko YG Lee JS | | 0，，： | 1 |
| 19 | Viral folliculitis on the face 显示文摘 | Jang KA Kim SH Choi JH | 2000 | Br J Dermatol2000，142，3： | 1 |
| 20 | SLC26A4 genotypes and phenotypes associated with enlargement of the vestibular aq- ueduct显示文摘 | ho T Choi lAY King KA | 2011 | Cell Physiol Biochem2011，28，： | 1 |
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