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| 1 | Dynamic magnetic resonance defecography in 10 asymptomatic volunteers显示文摘AIM: Evaluation of the wide range of normal findings in asymptomatic women undergoing dynamic magnetic resonance (MR) defecography. METHODS: MR defecography of 10 healthy female volunteers (median age: 31 years) without previous pregnancies or history of surgery were evaluated. The rectum was filled with 180 mL gadolinium ultrasound gel mixture. MR defecography was performed in the supine position. The pelvic floor was visualized with a dynamic T2-weighted sagittal plane where all relevant pelvic floor organs were acquired during defecation. The volunteers were instructed to relax and then to perform straining maneuvers to empty the rectum. The pubococcygeal line (PCGL) was used as the line of reference. The movement of pelvic floor organs was measured as the vertical distance to this reference line. Data were recorded in the resting position as well as during the defecation process with maximal straining. Examinations were performed and evaluated by two experienced abdominal radiologists without knowledge of patient history. RESULTS: Average position of the anorectal junction was located at -5.3 mm at rest and -29.9 mm during straining. The anorectal angle widened significantly from 93° at rest to 109° during defecation. A rectocele was diagnosed in eight out of 10 volunteers showing an average diameter of 25.9 mm. The bladder base was located at a position of +23 mm at rest and descended to -8.1 mm during defecation in relation to the PCGL. The bladder base moved below the PCGL in six out of 10 volunteers, which was formally defined as a cystocele. The uterocervical junction was located at an average level of +43.1 mm at rest and at +7.9 mm during straining. The uterocervical junction of three volunteers fell below the PCGL; described formally as uterocervical prolapse. CONCLUSION: Based on the range of standard values in asymptomatic volunteers, MR defecography values for pathological changes have to be re-evaluated. | Andreas G Schreyer Christian Paetzel Alois Fürst Lena M Dendl Elisabeth Hutzel René Müller-Wille Philipp Wiggermann Stephan Schleder Christian Stroszczynski Patrick Hoffstetter | 2012 | World Journal of Gastroenterology2012，18，46： | 7 |
| 2 | Isolation and characterisation of human gingival margin-derived STRO-1/MACS^+ and MACS^-cell populations显示文摘Recently,gingival margin-derived stem/progenitor cells isolated via STRO-1/magnetic activated cell sorting(MACS) showed remarkable periodontal regenerative potential in vivo.As a second-stage investigation,the present study's aim was to perform in vitro characterisation and comparison of the stem/progenitor cell characteristics of sorted STRO-1-positive(MACS^+) and STRO-1-negative(MACS^-) cell populations from the human free gingival margin.Cells were isolated from the free gingiva using a minimally invasive technique and were magnetically sorted using anti-STRO-1 antibodies.Subsequently,the MACS^+ and MACS^- cell fractions were characterized by flow cytometry for expression of CD14,CD34,CD45,CD73,CD90,CD105,CD146/MUC18 and STRO-1.Colony-forming unit(CFU) and multilineage differentiation potential were assayed for both cell fractions.Mineralisation marker expression was examined using real-time polymerase chain reaction(PCR).MACS^+ and MACS- cell fractions showed plastic adherence.MACS^+ cells,in contrast to MACS- cells,showed all of the predefined mesenchymal stem/progenitor cell characteristics and a significantly higher number of CFUs(P<0.01).More than 95%of MACS^+ cells expressed CD105,CD90 and CD73;lacked the haematopoietic markers CD45,CD34 and CD14,and expressed STRO-1 and CD146/MUC18.MACS- cells showed a different surface marker expression profile,with almost no expression of CD14 or STRO-1,and more than 95%of these cells expressed CD73,CD90 and CD146/MUC18,as well as the haematopoietic markers CD34 and CD45 and CD105.MACS^+ cells could be differentiated along osteoblastic,adipocytic and chondroblastic lineages.In contrast,MACS- cells demonstrated slight osteogenic potential.Unstimulated MACS^+ cells showed significantly higher expression of collagen I(P<0.05) and collagen III(P<0.01),whereas MACS^- cells demonstrated higher expression of osteonectin(P<0.05;MannWhitney).The present study is the first to compare gingival MACS^+ and MACS- cell populations demonstrating that MACS^+ cells,in contrast to MACS- cells,harbour stem/progenitor cell characteristics.This study also validates the effectiveness of the STRO-l/MACS^+technique for the isolation of gingival stem/progenitor cells.Human free gingival margin-derived STRO-1/MACS^+ cells are a unique renewable source of multipotent stem/progenitor cells. | Karim M Fawzy El-Sayed Sebastian Paris Christian Graetz Neemat Kassem Mohamed Mekhemar Hendrick Ungefroren Fred Fndrich Christof Drfer | 2015 | International Journal of Oral Science2015，7，2： | 6 |
| 3 | Lives Prod Sci显示文摘 | Rothschird M F Christian L L | 1988 | 19: 459-4711988，19，： | 1 |
| 4 | 查看详情显示文摘 | Torben S Thomas M Kjartan F Sφren L F Christian P | | 0，，： | 1 |
| 5 | Biological treatment of ammonium-rich wastewater by partial nitritation and subsequent anaerobic ammonium oxidation (anammox) in a pilot plant 显示文摘 | Christian F Boehler M Philipp H | 2002 | Journal of Biotechnology2002，99，3： | 1 |
| 6 | Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4显示文摘 | Miriam E. Jaax Krystin Krauel Thomas Marschall Sven Brandt Julia Gansler Birgitt Fürll Bettina Appel Silvia Fischer Stephan Block Christiane A. Helm Sabine Müller Klaus T. Preissner Andreas Greinacher | 2013 | Blood2013，，： | 1 |
| 7 | The alpha2chain of collagen type VI sequesters latent proforms of matrix-metallo-proteinases and modulates their activation and activity显示文摘 | CHRISTIAN F ULRIKE E MARION M | 2009 | Matrix Biology2009，28，： | 1 |
| 8 | Lectin- mediated drug targeting : history and applications 显示文摘 | CHRISTIANE B CLAUS M I JOHN F W | 2004 | Advanced Drug Delivery Reviews2004，56，3： | 1 |
| 9 | Occurences at mineralbacteria interface during oxidation of arsenoppyrite by thiobacillus ferrooxidans显示文摘 | Monroy F Christian M | 1995 | Biotechnology and Bioengineering1995，46，： | 1 |
| 10 | Biological treatment of ammonium-rich wastewater by partial nitritation and subsequent anaerobic ammonium oxidation (anammox) in a pilot plant 显示文摘 | Christian F Boehler M Phihpp H | 2002 | Journal of Biotechnology2002，99，3： | 1 |
| 11 | Evaluation and classification of RING-finger domains encoded by the Arabidopsis genome显示文摘 | Peter K Klaus F X M Christian S H | 2002 | Genome Biology2002，3，4： | 1 |
| 12 | Genetic control of frontleg weakness in duroc swine:Direct response to five generation of divergent selection显示文摘 | Rothschild M F Christian L L | 1988 | Livest Prod Sci1988，19，： | 1 |
| 13 | SMN-mediated assembly of RNPs:a complex story显示文摘 | Gunter M Christian E Utz F | 2002 | Trends Cell Biol2002，12，10： | 1 |
| 14 | Genetic evaluation for length of productive life in Slovak Pinzgau cattle显示文摘 | G á bor M Christian F Birgit F | | 0，，： | 1 |
| 15 | Expression of 1,25-Dihydroxyvitamin D3 receptor in the immune system显示文摘 | CHRISTIAN M V MARGHERITA T C HECTOR F D | 2000 | Archives of Biochemistry and Biophysics2000，374，2： | 1 |
| 16 | Long-term results after video-assisted thoracoscopic surgery for first-time and recurrent spontaneous pneumothorax显示文摘 | Rudolf A Hatz Michaela F Kaps Georgios Meimarakis Florian Loehe Christian Müller Heinrich Fürst | 2000 | The Annals of Thoracic Surgery2000，，1： | 1 |
| 17 | Three - in - one blocks with ropivacaine:evaluation of sensory onset time and quality of sensory block 显示文摘 | Peter M Christiane O Barbara F | 2000 | Anesth Analg2000，90，： | 1 |
| 18 | Changes in Body Composition: Growth in Healthy School -age During Children 显示文摘 | Christian M Kim F | 1998 | Appl Radiat Lsot1998，49，： | 1 |
| 19 | Temporal evolution of the nanostrueture of Al(Sc,Zr) alloys: part Ⅰ- chemical compositions of Al3 ( Sc 1 -xZrx) precipitates 显示文摘 | CHRISTIAN B F JOANNE L M DAVID N S | 2005 | Acta Materialia2005，53，： | 1 |
| 20 | Temporal evolution of the nanostructure of Al(Sc, Zr) alloys: part Ⅱ - coarsening of Al3 (Sc 1-xZrx) precipitates 显示文摘 | CHRISTIAN B F JOANNE L M DAVID N S | 2005 | Acta Materialia2005，53，： | 1 |
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