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| 1 | 小胶质细胞对星形胶质细胞的免疫和神经保护功能的调节作用(英文)显示文摘在中枢神经系统中,小胶质细胞和星形胶质细胞对神经元的发育、功能维持及细胞存活具有重要的作用。但在炎症反应过程中,星形胶质细胞增生的作用及其对神经元的影响目前并不十分清楚。因此,本研究对不同种类的细胞进行培养,给予细菌脂多糖(lipopolysaccharide,LPS)刺激,观察各种细胞的反应。结果显示,星形胶质细胞可以减轻炎症反应的神经元毒性,提示星形胶质细胞增生主要具有神经保护作用。如果去掉上清液中由星形胶质细胞分泌的胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF),这种神经保护作用显著降低。为了研究星形胶质细胞的免疫功能,本研究培养了高浓度的星形胶质细胞,并发现LPS不能诱导肿瘤坏死因子(tumor necrosis factor,TNF)-α及诱导型一氧化氮合酶(inducible nitric oxide synthase,iN OS)/一氧化氮(nitric oxide,NO)(iN OS/NO)释放。但如果在培养的高浓度星形胶质细胞中增加0.5%~1%的小胶质细胞,则可以诱导TNF-α及iN OS/NO的释放。这提示小胶质细胞和星形胶质细胞间的相互作用对于LPS诱导星形胶质细胞释放前炎症因子及GDNF是必须的。我们还发现,小胶质细胞释放的TNF-α可以通过旁分泌作用调节星形胶质细胞的神经保护功能。综上所述,本研究结果提示星形胶质细胞可能不会直接被LPS激活,而是通过与小胶质细胞相互作用被激活,释放神经营养因子,减少因炎症反应激活的小胶质细胞释放的毒性物质对神经元的损害作用。 | Chen SH Oyarzabal EA Sung YF Chu CH Wang Q Chen SL Lu RB Hong JS 唐颖馨 | 2015 | 神经损伤与功能重建2015，10，1： | 9 |
| 2 | Decomposition and Reformulation of Banxia Baizhu Tianma Decoction:A Vasodilatory Approach显示文摘Objective To decompose and reformulate Banxia Baizhu Tianma Decoction(BBT) in order to optimize its ratio for vasodilatory effect.The fingerprints of these six component herbs were also studied via Tri-step FTIR analysis.Methods The herbal components of BBT were extracted separately with different solvents,such as 95%ethanol,50%ethanol,and distilled water.The vasodilatory effect of the extracts was studied using the in vitro pre-contracted aortic ring model.Among these extracts,the water extracts of Pinellia ternata[PT(W)]and Citri reticulatae[CR(W)],50%ethanol extracts of Castrodia elata[GE(50)]and Clycyrrhiza uralensis[GU(50)],and 95%ethanol extracts of Atractylodes macrocephala[AM(E)],and Poria cocos[PC(E)]were selected for the orthogonal stimulus-response compatibility group study due to their high effectiveness in vasodilation.Results The best combination ratio(G2) was GE(50),GU(50),AM(E),PC(E),CR(W),and PT(W) at EC_0,EC_5,EC_5,EC_5,EC_5,and EC_5,with EC_(50) of(0.06 ± 0.01) mg/mL.Comparison between the vasodilatory effects of extracts derived from G2 and BBT were also studied.From the results,the 50%ethanol extract following G2 ratio was found to be most potent extract with the highest vasodilatory effect compared with other extracts derived from G2 or BBT,with EC_(50) of(0.05 ±0.005) mg/mL.Conclusion The optimum ratio and appropriate extraction method for the new BBT formulae are obtained.G2 is determined as the best formulae with the highest potency in producing the vasodilatory effect on isolated rat aortic rings.The results obtained suggest that 50%ethanol is found to be the best solvent to extract the vasoactive compounds of G2 in order to exhibit the highest efficacy of vasodilatory effect. | Chu Shan Tan Yean Chun Loh Yung Sing Ch'ng Mariam Ahmad Mohd.Zaini Asmawi Mun Fei Yam | 2017 | Chinese Herbal Medicines2017，9，2： | 3 |
| 3 | Video-assisted cardiac surgery in closure of atrial septal defect显示文摘 | Chang CH Lin PJ Chu JJ | 1996 | Ann Thorac Sung1996，62，3： | 1 |
| 4 | Inhibition of vascular endothelial cell morphogeneais in cultures by limbal epithelial cells 显示文摘 | Ma DHK Tsai RJF Chu WK Kao CH Chen JK | 1999 | Invest Ophthalmol Vis Sci1999，40，： | 1 |
| 5 | Factorial designs combined with the steepest ascent method to optimize serum-flee media for CHO cells 显示文摘 | Liu CH Chu IM Hwang SM | 2011 | Enzy Microbial Tech2011，28，45： | 1 |
| 6 | Glycated hemoglobin vari&bility and retinopathy progression in type 1 di&betes:b month-to-moth inst&bility & better predictor?显示文摘 | Ch&ng CH Chu&ng LM | 2014 | J Diabetes Investig2014，5，2： | 1 |
| 7 | Tyrosine phosphorylation ofgrowth factor receptor-bound protein-7 by focal adhesion kinase inthe regulation of cell migration,proliferation,and tumorigenesis显示文摘 | Chu PY Huang LY Hsu CH | 2009 | J Biol Chem2009，284，20： | 1 |
| 8 | Superselective transarterial chemoembolization vs hepatic resection for resectable earlystage hepatocellular carcinoma in pations with Child-Pugh class a liver function显示文摘 | Hsu KF Chu CH Chan DC | 2012 | Eur J Radiol2012，81，3： | 1 |
| 9 | Randomized trial on fluorides and sealants for fissure caries prevention显示文摘 | Liu BY Lo EC Chu CH | 2012 | J Dent Res2012，91，8： | 1 |
| 10 | Video - assisted coronary artery bypass grafting during hypothermic fibrillatory arrest 显示文摘 | Lin PJ Chang CH Chu J J | 1997 | Ann Thorac Sur~1997，63，4： | 1 |
| 11 | Terbutaline inhalation suppresses fentanyl-induced coughing显示文摘 | Hsing CH Chu YC | 1996 | Can J Anaesth1996，43，： | 1 |
| 12 | Normal T Cell Response and in Vivo Magnetic Resonance Imaging of T Cells Loaded with HIV Transactivator-Peptide-Derived Superparamagnetic Nanoparticles 显示文摘 | Dodd CH Hsu HC Chu WJ | 2001 | J Immunol Methods2001，256，12： | 1 |
| 13 | Factorial designs combined with the steepest ascent method to optimize serum-free media for ex vivo expansion of human hematopoietic progenitor cells 显示文摘 | Yao CL Liu CH Chu IM | 2003 | Enzyme Microb Tech2003，33，： | 1 |
| 14 | Caries status of preschool children in Hong Kong显示文摘 | Chu CH Fung DSH Lo ECM | 1999 | Br Dent J1999，187，： | 1 |
| 15 | Prognostic factor of hyDer glycemic hyperosmolar nonketotic state显示文摘 | Chu CH Lee JK Lam HC | 2001 | Chang Gung MED J2001，24，6： | 1 |
| 16 | Association of severity of conjuncti- val and corneal calcification with all-cause 1-year mortality in mainte- nance haemodialysis patients 显示文摘 | Hsiao CH Chao A Chu SY | 2011 | Nephrol Dial Transplant2011，26，8： | 1 |
| 17 | Factors predicting reintubation after unplanned extubation显示文摘 | Chen CZ Chu YC Lee CH | 2002 | J Formos Med Association2002，101，8： | 1 |
| 18 | Prognostic factor of hyperglycemic hyperosmolar nonketotic state 显示文摘 | CHU CH LEE JK LAM HC | 2001 | Chang Gung MED J2001，24，6： | 1 |
| 19 | The effect of cognitive behavioral group therapy for depression: a meta-analysis 2000 -2010 显示文摘 | Feng CY Chu H Chen CH | 2012 | Worldviews Evid Based Nurs2012，9，1： | 1 |
| 20 | Uric acid level as a risk marker for metabolic syndrome: a Chinese cohort study显示文摘 | Yang T Chu CH Bai CH | 2012 | Atherosclerosis2012，220，2： | 1 |
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