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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent 显示文摘 | Elbein SC Chu WS Das SK et ol | 2007 | Diabetologia2007，50，8： | 1 |
| 3 | Lack of association between ABCB1, ABCG2, and ABCC2 genetic polymor- phisms and multidrug resistance in partial epilepsy显示文摘 | Kim DW Lee SK Chu K | 2009 | Epilepsy Res2009，84，1： | 1 |
| 4 | Lansoprazole for the prevention of recurrences of ulcer complications from long term low dose aspirin use显示文摘 | Lai KC Lam SK Chu KM | 2002 | N Engl J Med2002，346，26： | 1 |
| 5 | Liver Pyrnvate Kinase Polymorphisms Are Associated With Type 2 Diabetes in Northern European Caucasians显示文摘 | Wang H Chu W Das SK | | 0，，09： | 1 |
| 6 | Vrolo palatoglossal junctional ulcers an early clinical sign of exantnem subitum due to human herpesvirus6显示文摘 | Chus KB Lam SK Sazaly AB | 1999 | Med J Malaysia1999，54，1： | 1 |
| 7 | Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia 显示文摘 | Woo PC Lau SK Chu CM | 2005 | J Virol2005，79，2： | 1 |
| 8 | Variations in the management of acute exacerbations of chronic obstructive pulmonary disease显示文摘 | Sandhu SK Chu J Yurkovich M | 2013 | Can Respir J2013，20，3： | 1 |
| 9 | Characterization and complete genome sequence of a novel eoronavirus, coronavirus HKU1, from patients with pneumonia 显示文摘 | Woo PC Lau SK Chu CM | 2005 | J Virol2005，79，2： | 1 |
| 10 | Early prediction of tumor recurrence after curative resection of gastric carci-noma by measuring soluble E-cadherin显示文摘 | Chan AO Chu KM Lam SK | 2005 | Cancer2005，104，4： | 1 |
| 11 | Lansoprazole for the prevention of recurrences of ulcer complications from long term low-dose aspirin use显示文摘 | Lai KC Lam SK Chu KM | 2002 | N Engl J Med2002，346，26： | 1 |
| 12 | Soluble E-cadherin is a valid prognosis marker in gastric carcinoma显示文摘 | Chan AO Lam SK Chu KM | 2001 | Gut2001，48，6： | 1 |
| 13 | Liver pyruvate kinase polymorphisms are associated with type 2 diabetes in northern European Caucasians显示文摘 | WANG H CHU W DAS SK | 2002 | Diabetes2002，51，9： | 1 |
| 14 | Differential expression of MUC1,MUC2 and MUC5AC in carcinomas of various sites:an immuno-histochemical study显示文摘 | Lau SK Weiss LM Chu PG | 2004 | Am J Clin Pathol2004，122，1： | 1 |
| 15 | Transcription factor 7-like 2 polymorphisms and type 2 diabetes,glucose homeostasis traits and gene expression in US participants of European and African descent显示文摘 | Elbein SC Chu WS Das SK | 2007 | Diabetologia2007，50，8： | 1 |
| 16 | Epidemiology of human papillomavirus infection and cervical cancer and future perspectives in Hong Kong, Singapore and Taiwan 显示文摘 | Tay SK Ngan HY Chu TY | 2008 | Vaccine2008，26，12： | 1 |
| 17 | Myxoid solitary fibrous tumor: a clin- icopathologic study of three cases 显示文摘 | Lau SK Weiss LM Chu PG | 2009 | Virchows Arch2009，454，2： | 1 |
| 18 | Distinct roles of pattern rec- ognition receptors CD14 and Toil - like receptor 4 in acute lung injury 显示文摘 | JeyascclanS Chu HW Young SK | 2005 | Infect Immune2005，73，3： | 1 |
| 19 | Epidemiology of human papillomavirus infection and cervical cancer and future perspec- tives in Hong Kong, Singapore and Taiwan显示文摘 | Tay SK Ngan HY Chu TY | 2008 | Vaccine2008，6，12： | 1 |
| 20 | Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia显示文摘 | Woo PC Lau SK Chu CM | 2005 | J Virol2005，79，： | 1 |
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