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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Liver iron transport显示文摘肝在铁新陈代谢起一个中央作用。它是为铁的主要存储地点并且也表示涉及铁运输和铁动态平衡的规定的分子的一个复杂范围。与肝的铁运输或规定联系的越来越多的基因被识别了。这些包括转铁蛋白受体(TFR1 并且 2 ) , ferrireductase (STEAP3 ) ,运输 ers 二价的金属 transporter-1 (DMT1 ) 和象 haemochromatosis 蛋白质, HFE 和 haemojuvelin (HJV ) 一样的 ferroportin (FPN ) ,它正在表明分子。许多也这些基因参予铁集中于肝的肽 hepcidin 的规章的小径。然而,我们开始仍然仅仅正在理解在肝之间的复杂相互作用熨运输和铁动态平衡。这评论在铁运输和铁动态平衡的规定构画出我们铁新陈代谢和他们的角色的分子的当前的知识。 | Ross M Graham Anita CG Chua Carly E Herbison John K Olynyk Debbie Trinder | 2007 | World Journal of Gastroenterology2007，13，35： | 12 |
| 3 | Potent antitumor efficacy of an E1B 55kDa-deficient adenovirus carrying murine endostatin in hepatocellular carcinoma显示文摘 | Li G Sham J Yang J Su C Xue H Chua D Sun L Zhang Q Cui Z Wu M Qian Q | 2005 | 第二军医大学学报2005，26，11： | 9 |
| 4 | Gastrointestinal perforation in metastatic colorectal cancer patients with peritoneal metastases receiving bevacizumab显示文摘AIM:To investigate the safety and efficacy of adding bevacizumab to first-line chemotherapy in metastatic colorectal cancer patients with peritoneal disease.METHODS:We compared rates of gastrointestinal perforation in patients with metastatic colorectal cancer and peritoneal disease receiving first-line chemotherapy with and without bevacizumab in three distinct cohorts:(1) the AGITG MAX trial(Phase Ⅲ randomised clinical trial comparing capecitabine vs capecitabine and bevacizumab vs capecitabine,bevacizumab and mitomycin C);(2) the prospective Treatment of Recurrent and Advanced Colorectal Cancer(TRACC) registry(any first-line regimen ± bevacizumab);and(3) two cancer centres in New South Wales,Australia [Macarthur Cancer Therapy Centre and Liverpool Cancer Therapy Centre(NSWCC) from January 2005 to Decenber 2012,(any first-line regimen ± bevacizumab).For the AGITG MAX trial capecitabine was compared to the other two arms(capecitabine/bevacizumab and capecitabine/bevacizumab/mitomycin C).In the AGITG MAX trial and the TRACC registry rates of gastrointestinal perforation were also collected in patients who did not have peritoneal metastases.Secondary endpoints included progression-free survival,chemotherapy duration,and overall survival.Time-toevent outcomes were estimated using the Kaplan-Meier method and compared using the log-rank test.RESULTS:Eighty-four MAX,179 TRACC and 69 NSWCC patients had peritoneal disease.There were no gastrointestinal perforations recorded in either the MAX subgroup or the NSWCC cohorts.Of the patients without peritoneal disease in the MAX trial,4/300(1.3%) in the bevacizumab arms had gastrointestinal perforations compared to 1/123(0.8%) in the capecitabine alone arm.In the TRACC registry 3/126(2.4%) patients who had received bevacizumab had a gastrointestinal perforation compared to 1/53(1.9%) in the chemotherapy alone arm.In a further analysis of patients without peritoneal metastases in the TRACC registry,the rate of gastrointestinal perforations was 9/369(2.4%) in the chemotherapy/bevacizumab group and 5/177(2.8%) in the chemotherapy alone group.The addition of bevacizumab to chemotherapy was associated with improved progression-free survival in all three cohorts:MAX 6.9 m vs 4.9 m,HR = 0.64(95%CI:0.42-1.02);P = 0.063;TRACC 9.1 m vs 5.5 m,HR = 0.61(95%CI:0.37-0.86);P = 0.009;NSWCC 8.7 m vs 6.8 m,HR = 0.75(95%CI:0.43-1.32);P = 0.32.Chemotherapy duration was similar across the groups.CONCLUSION:Patients with peritoneal disease do not appear to have an increased risk of gastrointestinal perforations when receiving first-line therapy with bevacizumab compared to systemic therapy alone. | Aflah Roohullah Hui-Li Wong Katrin M Sjoquist Peter Gibbs Kathryn Field Ben Tran Jeremy Shapiro Joe Mckendrick Desmond Yip Louise Nott Val Gebski Weng Ng Wei Chua Timothy Price Niall Tebbutt Lorraine Chantrill | 2015 | World Journal of Gastroenterology2015，21，17： | 3 |
| 5 | The role of synchronization in digital communications using chaos-Part I: Fundamentals of digital communications显示文摘 | KOLUMBAN G KENNEDY M P CHUA L O | 1997 | IEEE Trans Circuits Syst1997，44，10： | 2 |
| 6 | Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes显示文摘The term 'neurodevelopmental disorder' broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions. | MCALONAN Grainne M YU Kevin K CHAN Raymond C K CHUA Siew E CHEUNG Charlton | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 7 | From the Head and the Heart: Locating Cognition-and Affect- based Trust in Managers' Professional Networks显示文摘 | CHUA R Y J INGRAM P MORRIS M | 2008 | Academy of Management Journal2008，，： | 1 |
| 8 | Immuno- prophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization显示文摘 | HSU C H CHUA K Y TAO M H et a | 1996 | Nat Med1996，2，： | 1 |
| 9 | Neural networks for nonlinear programming显示文摘 | Kennedy M P Chua L O | 1988 | IEEE Trans on Circuits and Systems1988，35，5： | 1 |
| 10 | Memristor cellular automata and mem?ristor discrete-time cellular neural networks显示文摘 | Itoh M Chua L O | 2009 | IntJ Bifur?cation Chaos2009，19，11： | 1 |
| 11 | PhaseⅡstudy of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinoma显示文摘 | CHUA D T WEI W I WONG M P | 2008 | Head Neck2008，30，： | 1 |
| 12 | Development of micro power generator--a review显示文摘 | Chou S K Yang W M Chua K J | 2011 | Applied Energy2011，88，1： | 1 |
| 13 | Whole-brain radiation therapy plus concomitant temozolomide for the treatment of brain metastases from non-small-cell lung cancer: a randomized, open-label phase Ⅱ study显示文摘 | Chua D Krzakowski M Chouaid C | 2010 | Clin Lung Cancer2010，11，3： | 1 |
| 14 | Production of polyhydroxyalkanoates (PHA) by activated sludge treating municipal wastewater: effect of pH, sludge retention time (SRT), and acetate concentration in influent 显示文摘 | Chua A S M Takabatake H Satoh H | 2003 | War Res2003，37，： | 1 |
| 15 | Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinorna显示文摘 | Chua M S Sun H Cheung S T | 2007 | Modern Pathology2007，20，： | 1 |
| 16 | The monome- sylates of 1-( 2' -deoxy-β-D-lyxofuranosyl )-thymine 显示文摘 | Horwitz J P Chua J Noel M Nucleosides V | 1964 | J Org Chem1964，29，7： | 1 |
| 17 | Auxin polar transport ls essential for the establishment of bilateral symmetry during early plant embryogenesis显示文摘 | Liu C M Xu Z H Chua N H | 1993 | The Plant Cell1993，5，： | 1 |
| 18 | Memristor oscillators显示文摘 | ITOH M CHUA L O | 2008 | International Journal of Bifurcation and Chaos2008，18，11： | 1 |
| 19 | Regression analysis on ionic liquid pretreatment of sugarcane bagasse and assessment of structural changes 显示文摘 | Yoon L W Ang T N Ngoh G C Chua A S M | 2012 | Biomass andBioenergy2012，36，： | 1 |
| 20 | Achieving better energy- efficient air conditioning-A review of technologies and strategie- s显示文摘 | Chua K J Chou S K Yang W M | 2013 | Applied Energy2013，104，： | 1 |
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