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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | Tarsal sinus: arthrographic, MR imaging, MR arthrographic, and pathologic findings in cadavers and retrospective study data in patients with sinus tarsi syndrome显示文摘 | Lektrakul N Chung C B Lai Y M | 2001 | Radiology2001，219，6： | 1 |
| 3 | 显示文摘 | Choi W B Chung D S Kang J H | 1999 | Applied Physics Letters1999，75，20： | 1 |
| 4 | Switched-capacitor-based dc-to-dc converter with improved input current waveform显示文摘 | B O A Ioinovici | 1996 | Proc of IEEE ISCAS1996，，： | 1 |
| 5 | bimultaneous determination of anabolic steroids and synthetic hormones in meat by freezing- lipid filtration, solidphase extraction and gas chromatography- mass spectrometry 显示文摘 | SEO J KIM H Y CHUNG B C | 2005 | J Chromatogr A2005，1067，12： | 1 |
| 6 | The effect of coupling agent on electrical and mechanical properties of carbon fiber/phenolic resin composites 显示文摘 | Choi M H J eon B H Chung I J | 2000 | Polymer2000，41，9： | 1 |
| 7 | 显示文摘 | Choi M H Jeon B H Chung I J | 2000 | Polymer2000，41，： | 1 |
| 8 | Contour parallel offset machining without tool-retractions 显示文摘 | Park S C Chung Y C Choi B K | 2003 | Computer-Aided Design2003，35，9： | 1 |
| 9 | A study on technique to estimate impact location of loose part us- ing wigner-ville distribution显示文摘 | Kim Y B Kim S J Chung H D | 2003 | Progress in Nuclear Energy2003，43，14： | 1 |
| 10 | Plant species richness, elevated CO2 and atmospheric nitrogen decomposition alter soil microbial community composition and function显示文摘 | CHUNG H ZAK D R REICH P B | 2007 | Global Change Biology2007，13，： | 1 |
| 11 | Glutathione Peroxidase 3 Mediates the Antioxidant Effect of Peroxisome Proliferator-Activated Receptor 7 in Human Skeletal Muscle Cells 显示文摘 | Chung S S Kim M Youn B S | 2009 | Molecular and Cellular Biology2009，29，1： | 1 |
| 12 | 查看详情显示文摘 | (e) Kim D C Lee Y R Yang B -S Shin K J Kim D J Chung B Y Yoo K H | | 0，，： | 1 |
| 13 | Bioreduction of selenate using a hydrogen-based membrane biofilm reactor 显示文摘 | CHUNG J NERENBERG R RITTMANN B E | 2006 | Environmental Science & Technology2006，40，5： | 1 |
| 14 | Corporate Governance and Market Valuation of Capital and RD Investments显示文摘 | Chung K Wright P Kedia B | 2003 | Review of Finan- cial Economics2003，，12： | 1 |
| 15 | Rohust optimization for emergency logistic planning:Risk mitigation in humanitarian relief supply chains显示文摘 | Ben-Tal A Chung B D Mandala S R Yao T | 2011 | Transportation Research Part B2011，45，8： | 1 |
| 16 | Application of SELDI-TOF mass spectrometry for the identification of differentially expressed proteins by formaldehyde exposure 显示文摘 | JUNG Y M CHUNG H Y HAN B D | 2006 | Toxicol Lett2006，164，1： | 1 |
| 17 | Real-time PCR for quantitation of porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 in naturally-infected and challenged pigs 显示文摘 | Chung W B Chan W H Chaung H C | 2005 | Journal of Virological Methods2005，124，12： | 1 |
| 18 | Real-time PCR for quantitation of porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 in naturally-infected and challenged pigs 显示文摘 | Chung W B Chan W H Chaung H C | 2005 | J Virol Methods2005，124，12： | 1 |
| 19 | Identification and etiology of new disease, Corynespora leaf spot of cucumber caused by Corynespora melonis (Cook)Lindaw in green house cultivation in Korea显示文摘 | Kang S W Kwon J H Chung B K | 1993 | RDA Journal of Agricultural Science1993，35，： | 1 |
| 20 | NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and YPXL late domains 显示文摘 | Chung HY Morita E von Schwedler U Mailer B Kruusslich HG Sundquist WI | 2008 | J Virol2008，82，10： | 1 |
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