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| 1 | IL28B polymorphism as a predictor of antiviral response in chronic hepatitis C显示文摘AIM:To evaluate the effect of single nucleotide polymorphisms of interleukin(IL)-28B,rs12979860 on progression and treatment response in chronic hepatitis C.METHODS:Patients(n = 64;37 men,27 women;mean age,44 ± 12 years) with chronic hepatitis C,genotype 1,received treatment with peg-interferon plus ribavirin.Genotyping of rs12979860 was performed on peripheral blood DNA.Histopathological assessment of necroinflammatory grade and fibrosis stage were scored using the METAVIR system on a liver biopsy sample before treatment.Serum viral load,aminotransferase activity,and insulin level were measured.Insulin resistance index,body mass index,waist/hip ratio,percentage of body fat and fibrosis progression rate were calculated.Applied dose of interferon and ribavirin,platelet and neutrophil count and hemoglobin level were measured.RESULTS:A sustained virological response(SVR) was significantly associated with IL28B polymorphism(CC vs TT allele:odds ratio(OR),25;CC vs CT allele:OR,5.4),inflammation activity(G < 1 vs G > 1:OR,3.9),fibrosis(F < 1 vs F > 1:OR,5.9),platelet count(> 200 × 10 9 /L vs < 200 × 10 9 /L:OR,4.7;OR in patients with genotype CT:12.8),fatty liver(absence vs presence of steatosis:OR,4.8),insulin resistance index(< 2.5 vs > 2.5:OR,3.9),and baseline HCV viral load(< 10 6 IU/mL vs > 10 6 IU/mL:OR,3.0).There was no association with age,sex,aminotransferases activity,body mass index,waist/hip ratio,or percentage body fat.There was borderline significance(P = 0.064) of increased fibrosis in patients with the TT allele,and no differences in the insulin resistance index between groups of patients with CC,CT and TT alleles(P = 0.12).Spearman's rank correlation coefficient between insulin resistance and stage of fibrosis and body mass index was r = 0.618 and r = 0.605,respectively(P < 0.001).Significant differences were found in the insulin resistance index(P = 0.01) between patients with and without steatosis.Patients with the CT allele and absence of a SVR had a higher incidence of requiring threshold dose reduction of interferon(P = 0.07).CONCLUSION:IL28B variation is the strongest host factor not related to insulin resistance that determines outcome of antiviral therapy.Baseline platelet count predicts the outcome of antiviral therapy in CT allele patients. | Andrzej Ciela Monika Bociaga-Jasik Iwona Sobczyk-Krupiarz Mikolaj K Glowacki Danuta Owczarek Dorota Cibor Marek Sanak Tomasz Mach | 2012 | World Journal of Gastroenterology2012，18，35： | 4 |
| 2 | A Review of Speech Coding显示文摘AReviewofSpechCodingBaoChangchun(DepartmentofElectronicEngineering,BeijingPolytechnicUniversity,Beijing100022)FanChangxin?.. | Bao ChangchunAssociate professor of Information Engineering, Beijing Polytechnic University, Ph.D, CIE senior member (Department of Electronic Engineering, Beijing Polytechnic University, Beijing 100022) Fan ChangxinProfessor with Xidian University, C | 1998 | 通信学报1998，19，5： | 3 |
| 3 | Intrahepatic expression of genes related to metabotropic receptors in chronic hepatitis显示文摘AIM:To screen for genes related to metabotropic receptors that might be involved in the development of chronic hepatitis.METHODS:Assessment of 20 genes associated with metabotropic receptors was performed in liver specimens obtained by punch biopsy from 12 patients with autoimmune and chronic hepatitis type B and C.For this purpose,a microarray with low integrity grade and with oligonucleotide DNA probes complementary to target transcripts was used.Evaluation of gene expression was performed in relation to transcript level,correlation between samples and grouping of clinical parameters used in chronic hepatitis assessment.Clinical markers of chronic hepatitis included alanine and aspartate aminotransferase,-glutamyltranspeptidase,alkaline phosphatase and cholinesterase activity,levels of iron ions,total cholesterol,triglycerides,albumin,glucose,hemoglobin,platelets,histological analysis of inflammatory and necrotic status,fibrosis according to METAVIR score,steatosis,as well as anthropometric body mass index,waist/hip index,percentage of adipose tissue and liver size in ultrasound examination.Gender,age,concomitant diseases and drugs were also taken into account.Validation of oligonucleotide microarray gene expression results was done with the use of quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS:The highest(0.002 < P < 0.046) expression among genes encoding main components of metabotropic receptor pathways,such as the α subunit of G-coupled protein,phosphoinositol-dependent protein kinase or arrestin was comparable to that of angiotensinogen synthesized in the liver.Carcinogenesis suppressor genes,such as chemokine ligand 4,transcription factor early growth response protein 1 and lysophosphatidic acid receptor,were characterized by the lowest expression(0.002 < P < 0.046),while the factor potentially triggering hepatic cancer,transcription factor JUN-B,had a 20-fold higher expression.The correlation between expression of genes of protein kinases PDPK1,phosphoinositide 3-kinase and protein kinase A(Spearman's coefficient range:0.762-0.769) confirmed a functional link between these enzymes.Gender(P = 0.0046) and inflammation severity,measured by alanine aminotransferase activity(P = 0.035),were characterized by diverse metabotropic receptor gene expression patterns.The Pearson's coefficient ranging from-0.35 to 0.99 from the results of qRT-PCR and microarray indicated that qRT-PCR had certain limitations as a validation tool for oligonucleotide microarray studies.CONCLUSION:A microarray-based analysis of hepatocyte metabotropic G-protein-related gene expression can reveal the molecular basis of chronic hepatitis. | Andrzej Ciesla Maciej Kusmider Agata Faron-Górecka Marta Dziedzicka-Wasylewska Monika Bocisga-Jasik Danuta Owczarek Irena Cieko-Michalska Dorota Cibor Tomasz Mach | 2012 | World Journal of Gastroenterology2012，18，31： | 2 |
| 4 | Pathogenetie justification of statin use in ischaemic stroke prevention according to inflammatory theory in development of atherosclerosis 显示文摘 | Kotlega D Cie wie S Turowska-Kowalska J | 2012 | Neurol Neurochir Po12012，46，： | 1 |
| 5 | Early antibody responses in human sehistosomiasis显示文摘 | Evangard B Hammerstrom L Smith CIE | 1990 | Clin Exp Immunol1990，80，1： | 1 |
| 6 | Restriction fragment length polymorphisms in myogenin and myf-3 genes and their influence on lean meat content in pigs 显示文摘 | Cie slak D Kapelanski W Blicharski T | 2000 | J Anita Breed Genet2000，17，： | 1 |
| 7 | Connective tissue growth factor-a novel medlator of angiotensin Ⅱ-stimulated cardiac fibroblast activation in heart faihrc in rats显示文摘 | Ahmed MS Cie E Vinge LE | 2004 | J Mol Cell Cardiol2004，36，3： | 1 |
| 8 | Effects of excessive body weight on postural eontrol显示文摘 | B? aszczyk JW Cie? linska-? wider J Plewa M Zahorska-Markiewicz B Markiewicz A | 2009 | Journal of Biomechanics2009，42，9： | 1 |
| 9 | Metal release and formation of surface precipitate at stainless steel grade 316 and Hanks solution interface – Inflammatory response and surface finishing effects显示文摘 | Monika Cie?lik Witold Reczyński Anna Maria Janus Klas Engvall Robert P. Socha Andrzej Kotarba | 2009 | Corrosion Science2009，，5： | 1 |
| 10 | Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid显示文摘 | Joanna Czarnecka Marek Cie?lak Komoszyński Micha? | 2005 | Journal of Chromatography B2005，，1： | 1 |
| 11 | Evaluation of QuEChERS method for the determination of organochlorine pesticide residues in selected groups of fruits显示文摘 | CIE(S)LIK E | | 0，，02： | 1 |
| 12 | Application of variable magnetic fields in medicine--15 years experience显示文摘 | Sieroń A Cie(s)lar G | 2003 | Wiad Lek2003，56，910： | 1 |
| 13 | Non-isothermal Studies on Mechanism And Kinetics of Thermal Decomposition of Cobalt(II) Oxalate Dihydrate显示文摘 | B. Ma?ecka E. Dro?d?-Cie?la A. Ma?ecki | 2002 | Journal of Thermal Analysis and Calorimetry2002，，3： | 1 |
| 14 | Telecommunications Infrastructure and Regional Economic Development: The Case of Poland 显示文摘 | Cie lik Andrzej Kaniewsk Magdalena | 2004 | Regional Studies2004，，38： | 1 |
| 15 | Low-cycle fatigue life of steel P92 under gradual loading显示文摘 | M Cie?la G Junak | 2012 | IOP Conference Series: Materials Science and Engineering2012，，1： | 1 |
| 16 | Puerperal illness,comparison with nonpuerperal controls显示文摘 | | 1982 | British J Psychiatry1982，141，： | 1 |
| 17 | Firm Heterogeneity,Foreign Market Entry Mode and Ownership Choice显示文摘 | Cie lik Andrzej and Michael Ryan | 2009 | Japan and the World Economy2009，21，3： | 1 |
| 18 | Low-molecular-weight organic acids in rhizosphere soils of durum wheat and their effect on cadmium bioaccumulation显示文摘 | Cie sli nski G Van Rees K C J Szmigielska A M | 1998 | Plant and Soil1998，203，： | 1 |
| 19 | Literal salience in on- line processing of idiomatic expressions by second language learners显示文摘 | Cie~licka A | | 0，，02： | 1 |
| 20 | Influence of paternal lymphocyte immunization on the selected subpopulations of peripheral blood lymphocytes in women with recurrent spontaneous abortions of unknown etiology显示文摘 | Szpakowski A Malinowski A Cie s'lak J | 2003 | Ginekol Pol2003，74，： | 1 |
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