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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Rapid nongenomic inhibitory effects of glucocorticoids on phagocytosis and superoxide anion production by macrophages显示文摘 | Long F Wang YX Liu L Zhou J Cui RY Jiang CL | 2005 | 第二军医大学学报2005，26，10： | 14 |
| 3 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 4 | 树突状细胞自然杀伤细胞凝集素群受体1促进小鼠动脉粥样硬化的发展显示文摘动脉粥样硬化发展过程中的坏死核心形成与慢性炎症反应有关,其促进斑块发展加快和不稳定。然而,坏死与动脉粥样硬化发展之间的分子生物学联系机制尚未完全清楚。 | 刘莉 叶鹏 Haddad Y Lahoute C Clément M Laurans L Metghalchi S Lynda Z Giraud A Loyer X Vandestienne M Wain-Hobson J Esposito B Potteaux S Ait-Oufella H Tedgui A Mallat Z Taleb S | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 5 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 6 | Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese显示文摘 | Judith Aron-Wisnewsky Caroline Minville Joan Tordjman Patrick Lévy Jean-Luc Bouillot Arnaud Basdevant Pierre Bedossa Karine Clément Jean-Louis Pépin | 2011 | Journal of Hepatology2011，，1： | 2 |
| 7 | The effect of recombinant human erythropoietin on neurovasculature repair after focal ischemic stroke in neonatal rats 显示文摘 | Keoqh CL Yu SP Wei L | 2007 | J Pharmacol Exp Ther2007，322，： | 1 |
| 8 | Small bowel hemorrhage: angiographic localization and intervention显示文摘 | Tillotson CL Geller SC Kantrowitz L | 1988 | Gastrointest Radiol1988，13，3： | 1 |
| 9 | Meta-analysis of defunctioning stomas in low anterior resection for rectal cancer显示文摘 | Tan WS Tang CL Shi L | 2009 | Br J Surg2009，96，5： | 1 |
| 10 | Antagonistic and agonisttic GnRH analogle treatment of precocious puberty:tracking gonadotropin concentrations in urine显示文摘 | Roth CL Brendel L Ruckert C | 2005 | Horm Res2005，63，5： | 1 |
| 11 | KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size显示文摘 | Corless CL McGreevey L Haley A | 2002 | Am J Pathol2002，160，5： | 1 |
| 12 | Clinical and molecular dilemmas in the diagnosis of familial epidermolysis bullosa pruriginosa显示文摘 | Ee HL Liu L Goh CL | 2007 | J Am Acad Dermatol2007，56，5： | 1 |
| 13 | Effect of peer support on prevention of postnatal depression among high risk women : muhisite randomized controlled trial显示文摘 | Dennis CL Hodnett E Kenton L | 2009 | BMJ2009，338，： | 1 |
| 14 | A Cross -cultural Exami- nation of Presenteeism and Supervisory Support 显示文摘 | Lu L Cooper CL Lin HY | 2003 | Career Development International2003，18，5： | 1 |
| 15 | Demodicidosis in childhood acute lymphohlastic leukemia: an opportunistic infection occurring with immunosuppression显示文摘 | Ivy SP Mackall CL Gore L | 1995 | J Pediatr1995，127，： | 1 |
| 16 | Urotensin-Ⅱ-mediated cardiomyocyte hypertrophy:effect of receptor antagonism and role of inflammatory mediators显示文摘 | Johns DG Ao Z Naselsky D Herold CL Maniscalco K Sarov-Blat L | 2004 | Naunyn Schmiedebergs Arch Pharmacol2004，370，4： | 1 |
| 17 | Successful treat- ment of oral squamous cell carcinoma with intralesional fluorouracil in a Malayan tapir CTapims indicus)显示文摘 | Miller CL Templeton RS Karpinski L | 2000 | J Zoo Wild1 Med2000，31，2： | 1 |
| 18 | A trial of lobaplatin (D-19466)in platinum ovarian cancer显示文摘 | Kavanagh JJ Creightoon L Edwards CL | 1995 | Gynecol Oncol1995，58，： | 1 |
| 19 | Chronic Myeloid Leukemia显示文摘 | Charles L Sawyers CL | 1999 | New Engl J reed1999，340，17： | 1 |
| 20 | Non-aspirin NSAIDs, cyclooxygenase-2 inhibitors and risk for cardiovascular events-stroke, acute myocardial infarction, and death from coronary heart disease 显示文摘 | Roumie CL Chorea NN Kaltenbach L | 2009 | Pharmacoepidemiol Drug Saf2009，18，11： | 1 |
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