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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Stem cell differentiation and human liver disease显示文摘Human stem cells are scalable cell populations capable of cellular differentiation.This makes them a very attractive in vitro cellular resource and in theory provides unlimited amounts of primary cells.Such an approach has the potential to improve our understanding of human biology and treating disease.In the future it may be possible to deploy novel stem cell-based approaches to treat human liver diseases.In recent years,eff icient hepatic differentiation from human stem cells has been achieved by several research groups including our own.In this review we provide an overview of the f ield and discuss the future potential and limitations of stem cell technology. | Wen-Li Zhou Claire N Medine Liang Zhu David C Hay | 2012 | World Journal of Gastroenterology2012，18，17： | 3 |
| 3 | 印度农业推广改革现状:战略重点和政策选择显示文摘独立以来,虽然印度农业推广经历了翻天覆地的变化,但是小农农民和其他弱势群体仍未参与到公共推广体系之中。许多组织性能问题妨碍了公共推广体系的效率和效果。这些问题包括人员的匮乏,较低的合作伙伴关系以及继续自上而下的线性推广方式。本文回顾了印度农业推广改革的现状,并基于比哈尔、喜马偕尔邦、马哈拉施特拉邦和泰米尔纳德邦等4个邦的实地调研,分析并进一步细化了当前的改革进程,在此基础上,提出了促进农业公共推广体系有序发展和运行的优先政策和战略选择。 | Suresh C Babu P K Joshi Claire J.Glendenning Kwadwo Asenso-Okyere Rasheed Sulaiman V 蔡彦虹(翻译) | 2017 | 世界农业2017，，7： | 2 |
| 4 | Tumorigenesissuppressor Pdcd4 dow n-regulates mitogen-activated pro-tein kinase 1 expression to suppress colon carcinoma cellinvasion显示文摘 | Yang H S Matthews C P Clair T | 2006 | Mol Cell Biol2006，26，4： | 1 |
| 5 | The molecular hiology of the flavin-containing nlonooxygenases of man显示文摘 | Phillips I R Dolphin C T Clair P | 1995 | Chem Biol Interact1995，96，1： | 1 |
| 6 | Effects of microcystin-LR on development of medaka fish embryos ( Oryzias latipes )显示文摘 | Claire Jacquet Violette Thermes Amaury de Luze Simone Puiseux-Dao Cécile Bernard Jean-Stéphane Joly Franck Bourrat Marc Edery | 2003 | Toxicon2003，，2： | 1 |
| 7 | Combining DEA Window Analysis with the Malmquist Index Approach in a Study of the Canadian Banking Industry显示文摘 | Mette Asmild Joseph C Paradi Vanita Aggarwall Claire Scha/fnit | 2004 | Journal of Productivity Analysis2004，，1： | 1 |
| 8 | Photocatalytic reduction of Ag2S04 by the dawson anion c - 6- and tetra- cobalt sandwich complexes 显示文摘 | Claire C C Delphine S Isabelle L | 2008 | Appl Catal: Environ2008，84，34： | 1 |
| 9 | TMS1,a novel pro-apoptotic caspase recruitment domain protein,is a target ofmethylation-induced gene silencing in human breast cancers显示文摘 | Kerry E C Beth/M Claire E B | 2000 | Cancer Res2000，60，22： | 1 |
| 10 | Uncertainty and value of information when allocating resources within and between healthcare programmes显示文摘 | Zaid C David E Claire M | 2008 | European Journal of Operational Research2008，191，2： | 1 |
| 11 | Automated drug dispensing system re- duces medication errors in an intensive care setting显示文摘 | Claire C Matthieu R Gaelle B | 2010 | Crit Care Med2010，38，12： | 1 |
| 12 | Small bowel metastases from primary carcinoma of the lung: clinical findings and outcome显示文摘 | Anne Berger Christophe Cellier Claire Daniel Cédric Kron Marc Riquet Jean-Philippe Barbier Paul-Henri Cugnenc Bruno Landi | 1999 | The American Journal of Gastroenterology1999，，7： | 1 |
| 13 | Association within a family of a balanced autosomal translocation with major mental illness显示文摘 | St Clair D Blackwood D Muir W Carothers A Walker M Spowart G Gosden C Evans H J | | 0，，8706： | 1 |
| 14 | Refraining crisis management显示文摘 | Pearson C M Clair J A | 1998 | Academy of Management Review1998，23，1： | 1 |
| 15 | Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment显示文摘 | Jane W Susan C Claire MAH | 2008 | American Journal of Clln- ical Nutrition2008，87，2： | 1 |
| 16 | Knowledge services: Your company ' s key to performance excellence 显示文摘 | St Clair C | 2001 | Information Outlook2001，5，6： | 1 |
| 17 | Tourism as experience显示文摘 | Richard C Prentice Stephen F Witt Claire Hamer | 1998 | Annals of Tourism Research1998，25，1： | 1 |
| 18 | Interstitial MR lymphography with conventional extracellular Gadolinium-based agent: assessment in rabbits显示文摘 | Stefan GR Claire C Jorg FD | 2001 | Radiology2001，218，3： | 1 |
| 19 | ULBP4 is a novel ligand for humanNKG2D 显示文摘 | Jan C Claire LS William AL | 2003 | Biochemicaland Biophysical Research Communication2003，305，3： | 1 |
| 20 | Refraining crisis management显示文摘 | Pearson C M Clair J A | 1998 | Academy of Management Review1998，23，1： | 1 |
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