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| 1 | National trends in resection of the distal pancreas显示文摘AIM:To investigate national trends in distal pancreatectomy(DP) through query of three national patient care databases.METHODS:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvement Project(NSQIP,2005-2010),and the Surveillance Epidemiology and End Results(SEER,2003-2009) databases using appropriate diagnostic and procedural codes we identified all patients with a diagnosis of a benign or malignant lesion of the body and/or tail of the pancreas that had undergone a partial or distal pancreatectomy.Utilization of laparoscopy was defined in NIS by the International Classification of Diseases,Ninth Revision correspondent procedure code;and in NSQIP by the exploratory laparoscopy or unlisted procedure current procedural terminology codes.In SEER,patients were identified by the International Classification of Diseases for Oncology,Third Edition diagnosis codes and the SEER Program Code Manual,third edition procedure codes.We analyzed the databases with respect to trends of inpatient outcome metrics,oncologic outcomes,and hospital volumes in patients with lesions of the neck and body of the pancreas that underwent operative resection.RESULTS:NIS,NSQIP and SEER identified 4242,2681 and 11 082 DP resections,respectively.Overall,laparoscopy was utilized in 15%(NIS) and 27%(NSQIP).No significant increase was seen over the course of the study.Resection was performed for malignancy in 59%(NIS) and 66%(NSQIP).Neither patient Body mass index nor comorbidities were associated with operative approach(P = 0.95 and P = 0.96,respectively).Mortality(3% vs 2%,P = 0.05) and reoperation(4% vs 4%,P = 1.0) was not different between laparoscopy and open groups.Overall complications(10% vs 15%,P < 0.001),hospital costs [44 741 dollars,interquartile range(IQR) 28 347-74 114 dollars vs 49 792 dollars,IQR 13 299-73 463,P = 0.02] and hospital length of stay(7 d,IQR 4-11 d vs 7 d,IQR 6-10,P < 0.001) were less when laparoscopy was utilized.One and two year survival after resection for malignancy were unchanged over the course of the study(ductal adenocarinoma 1-year 63.6% and 2-year 35.1%,P = 0.53;intraductal papillary mucinous neoplasm and nueroendocrine 1-year 90% and 2-year 84%,P = 0.25).The majority of resections were performed in teaching hospitals(77% NIS and 85% NSQIP),but minimally invasive surgery(MIS) was not more likely to be used in teaching hospitals(15% vs 14%,P = 0.26).Hospitals in the top decile for volume were more likely to be teaching hospitals than lower volume deciles(88% vs 43%,P < 0.001),but were no more likely to utilize MIS at resection.Complication rate in teaching and the top decile hospitals was not significantly decreased when compared to non-teaching(15% vs 14%,P = 0.72) and lower volume hospitals(14% vs 15%,P = 0.99).No difference was seen in the median number of lymph nodes and lymph node ratio in N1 disease when compared by year(P = 0.17 and P = 0.96,respectively).CONCLUSION:There appears to be an overall underutilization of laparoscopy for DP.Centralization does not appear to be occurring.Survival and lymph node harvest have not changed. | Armando Rosales-Velderrain Steven P Bowers Ross F Goldberg Tatyan M Clarke Mauricia A Buchanan John A Stauffer Horacio J Asbun | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 2 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 3 | Role of microfilaments in maintenance of proximal tubular structure and functional integrity 显示文摘 | Kellerman P S Clark R A Hoilien C A | 1990 | Am J Physiol1990，259，2： | 1 |
| 4 | Alumina-supported molybdenum phosphide hydroprocessing catalysts 显示文摘 | Clark P A Oyama S T | 2003 | Journal of Catalysis2003，218，： | 1 |
| 5 | The CD20 (Bp35) antigen is involved in activation of B cells from the GO to the G1 phase of the cell cycle显示文摘 | Clark E A Beverley P C | 1985 | J Immunol1985，135，6： | 1 |
| 6 | Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection显示文摘 | Halestrap A P Clarke S J Javadov S A | 2004 | Cardiovasc Res2004，61，3： | 1 |
| 7 | Use of a peptide rather than free amino acid nitrogen source in chemically defined 'elemental' diets显示文摘 | SILK D B A FAIRCLOUGH P D CLARK M L | 1980 | Journal of Parenteral and Enteral Nutrition1980，4，： | 1 |
| 8 | The effect of osteogenic growth factors on bone growth into a ceramic-filled defect around an implant显示文摘 | Clarke S A Brooks R A Lee P T | 2004 | Bone Joint Surg Br2004，22，5： | 1 |
| 9 | Labeling of mesenchymal stem cells by bioconjugated quantum dots 显示文摘 | SHAH B S CLARK P A MOIOLI E K | 2007 | Nano Lett2007，7，10： | 1 |
| 10 | Mitochondrial permeability transition pore opening during myocardial reperfusion a target for cardioproteetion 显示文摘 | Halestrap A P Clarke S J Javadov S A | 2004 | Cardiovasc Res2004，61，3： | 1 |
| 11 | MMCs for automotive engine applications显示文摘 | Mangin C Isaaes J A Clark J P | 1996 | JOM1996，48，2： | 1 |
| 12 | Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions显示文摘 | Pendle A F Clark G P Boon R | 2005 | Mol Biol Cell2005，16，： | 1 |
| 13 | Assimilation of snow covered area information into hydrologic and land-surface models显示文摘 | Clark M P Slater A G Barrett A P | 2006 | Advances in Water Resources2006，29，8： | 1 |
| 14 | Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca^2+ in T lymphocytes显示文摘 | Tamas P Hawley S A Clarke R G | 2006 | J Exp Med2006，203，7： | 1 |
| 15 | A method for the determination of nitrification rates in oligotrophicmarine seawater by gas chromatography/mass spectrometry显示文摘 | CLARK D R REES A P JOINT I | 2007 | Mar Chem2007，103，： | 1 |
| 16 | Yogurts from skim milk- whey protein concentrate blends显示文摘 | Cheng L J Augustina M A Clarke P T | 2000 | Austealian Journal of Dairy Technology2000，，55： | 1 |
| 17 | Experimental studies of the advanced fast ignitor scheme显示文摘 | Norreys P A Allott R Clarke R J | 2000 | Phys Plasmas2000，7，： | 1 |
| 18 | MRI segmentation:methods and applications显示文摘 | Clarke L P Ve1thuizen M R P Camacho A | 1995 | Magnita Resonance Imaging1995，13，3： | 1 |
| 19 | Phosphorusremoval by chemical precipitation in biological aerated fil-ter显示文摘 | CLARK T STEPHENSON T PEARCE P A | 1997 | Water Research1997，31，10： | 1 |
| 20 | Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection 显示文摘 | Halestrap A P Clarke S J Javadov S A | 2004 | Cardiovasc Res2004，61，3： | 1 |
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