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1555篇 您的检索式：作者名="Clark D R"

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	题名	作者	年代	出处	被引量
1	Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation显示文摘AIM: To investigate the interaction between castanospermine and cyclosporin A(Cs A) and to provide an explanation for it.METHODS: The alkaloid castanospermine was prepared from the seeds of Castanospermum austral consistently achieving purity. Rat heterotopic cardiac transplantation and mixed lymphocyte reactivity were done using genetically inbred strains of PVG(donor) and DA(recipient). For the mixed lymphocyte reaction stimulator cells were irradiated with 3000 rads using a linear accelerator. Cyclosporin A was administered by gavage and venous blood collected 2 h later(C_2). The blood levels of Cs A(Neoral) were measured by immunoassay which consisted of a homogeneous enzyme assay(EMIT) on Cobas Mira. Statistical analyses of interactions were done by an acceleratedfailure time model with Weibull distribution for allograft survival and logistic regression for the mixed lymphocyte reactivity.RESULTS: Castanospermine prolonged transplant survival times as a function of dose even at relatively low doses. Cyclosporin A also prolonged transplant survival times as a function of dose particularly at doses above 2 mg/kg. There were synergistic interactions between castanospermine and Cs A in the prolongation of cardiac allograft survival for dose ranges of Cs A by castanospermine of(0 to 2) mg/kg by(0 to 200) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) and(0 to 3) mg/kg by(0 to 100) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) respectively. The addition of castanospermine did not significantly increase the levels of cyclosporin A on day 3 or day 6 for all doses of Cs A. On the contrary, cessation of castanospermine in the presence of Cs A at 2 mg/kg significantly increased the Cs A level(P = 0.002). Castanospermine inhibited mixed lymphocyte reactivity in a dose dependent manner but without synergistic interaction. CONCLUSION: There is synergistic interaction between castanospermine and Cs A in rat cardiac transplantation. Neither the mixed lymphocyte reaction nor the metabolism of Cs A provides an explanation.	Adrian D Hibberd David A Clark Paul R Trevillian Patrick Mcelduff	2016	World Journal of Transplantation2016，6，1：	2
2	Fate of metals in waste combustion systems 显示文摘	Barton R G Clark W D Seeker W R	1990	Combustion Science and Technology1990，74，：	1
3	Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘	Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J	2004	Proc Natl Acad Sci USA2004，101，26：	1
4	Structure,antifer-romgnetism and superconductivity of the layered iron arsenide NaFeAs显示文摘	Parker D R Pitcher M J Clarke S J	2009	Chem Commun2009，28，16：	1
5	Varistor ceramics 显示文摘	CLARKE D R	1999	Journal of the American Ceramic Society1999，82，3：	1
6	Willingness to pay for flood and ecological risk reduction in an urban watershed显示文摘	Clark D E Novotny V Griffin R	2001	Water Science & Technology2001，45，9：	1
7	Congestion Control With Explicit Rate Indication显示文摘	Charny A Clark D Jain R	1995	IEEE1995，，：	1
8	Self- assembling organic nanotubes 显示文摘	Bong D T Clark T D Granja J R Ghadiri M R	2001	Angew Chem Int Ed Engl2001，40，6：	1
9	A method for the determination of nitrification rates in oligotrophicmarine seawater by gas chromatography/mass spectrometry显示文摘	CLARK D R REES A P JOINT I	2007	Mar Chem2007，103，：	1
10	An assessment of the utility of a non-metric digital camera for measuring standing trees显示文摘	CLARK N A WYNNE R H SCHMOLDT D L	2008	Computers and Electronics in Agriculture2008，28，：	1
11	Spectral discrimination of coral mortality states following a severe bleaching event 显示文摘	CLARK C D MUMBY P J CHISHOLM J R M	2000	International Journal of Remote Sensing2000，21，11：	1
12	Minority influence: The role of argument refutation of majority position and social support for the minority position显示文摘	Clark R D	1990	European Journal of Social Psychology1990，20，：	1
13	Comparative trace element geoehe- mistry of Tertiary basahs from Baffin Bay显示文摘	Nions R K Clarke D B	1972	Earth and Planetary Science letters1972，15，：	1
14	High frequency oscillatory ventilation versus conventional ventilation for infants with severe pulmonary dysfunction born at or near term 显示文摘	HENDERSON-SMART D J DE PAOLI A G CLARK R H	2009	Cochrane Database Syst Rev2009，3，00：	1
15	Varistor Ceramics显示文摘	Clarke D R	1999	Journal Of The A- merican Ceramic Society1999，82，3：	1
16	Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation显示文摘	SAMANT RS CLARK DW FILLMORE RA	2007	Mol Cancer2007，6，：	1
17	Thymocyte apoptosis induced by p53-dependent and independent pathways显示文摘	Purdie C A Harrison D J	1993	Nature1993，362，6423：	1
18	Metals and micronutrients-food safety issues显示文摘	McLaughlin M J Parker D R Clarke J M	1999	Field Crops Research1999，60，：	1
19	Net primary production in tropical forests: an evaluation and synthesis of existing field data显示文摘	Clark D A Brown S Kichlighter W K Charmbers J Q Thomlinson J R Ni J Holland E A	2001	Ecological Applications2001，11，2：	1
20	Modeling of modified atmosphere packaging based on designs with a membrane and perforations显示文摘	PAUL D R CLARKE R	2002	Journal of Membrane Science2002，208，：	1

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