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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | A novel integrated in vitro maturation and in vitro fertilization system for swine显示文摘 | Clark S G Walters E M Beebe D J | 2003 | Theriogenology2003，59，： | 1 |
| 3 | A Dynamic Model for Predicting Fouling Effects During the Uhrafihration of a Groundwater 显示文摘 | Wetterau G E Clark M M Anselme C | 1996 | Journal of Membrane Science1996，109，： | 1 |
| 4 | Assimilation of snow covered area information into hydrologic and land-surface models显示文摘 | Clark M P Slater A G Barrett A P | 2006 | Advances in Water Resources2006，29，8： | 1 |
| 5 | Prognostic factors and treatment decisions in axillary-node-negative breast cancer显示文摘 | MC GUIRE W L CLARK G M | 1992 | N En-gl J Med1992，326，26： | 1 |
| 6 | Identification and cloning of a key insecticide-metabolizing glutathione S-transferase(MdGST-6A)from a hyper insecticide-resistant strain of the housefly Musca domestica显示文摘 | Wei S H Clark A G Syvanen M | 2001 | Insect Biochem Mol Biol2001，31，12： | 1 |
| 7 | A Solution to the Simultaneous Localization and Map Building( SLAM )problem显示文摘 | Dissanayake M W M G Newman P Clark S | 2001 | IEEE Transactions on Robotics and Automation2001，17，3： | 1 |
| 8 | The effect of prestorage WBC reduction on the rates of febrile nonhemolytic transfusion reactions to platelet concentrates and RBC显示文摘 | YAZER M H PODLOSKKY L CLARKE G | 2004 | Transfusion2004，44，： | 1 |
| 9 | Snow data assimilation via an ensemble Kalman filter显示文摘 | Slater A G Clark M P | 2006 | Journal of Hydrometeorology2006，7，3： | 1 |
| 10 | A practical strategy for analysing multispecies distribution patterns显示文摘 | Field J G Clarke K R Warwick R M | 1982 | Mar Ecol Prog Ser1982，8，1： | 1 |
| 11 | Globular protein gelation:theory and experiments显示文摘 | CLARK A H KAVANAGH G M ROSS-MURPHY S B | 2001 | Food Hydrocolloids2001，15，： | 1 |
| 12 | A solution to the simultaneous localization and map building (SLAM) problem显示文摘 | Dissanayake M W M G Newman P Clark S | 2001 | IEEE Transactions on Robotics and Automation2001，17，3： | 1 |
| 13 | Luminescence dating of loess from the Liujiapo section, central China显示文摘 | Musson F M Clarke M L Wintle A G | 1994 | Quaternary Science Reviews1994，13，： | 1 |
| 14 | Human breast cancer:correlation of relapse and survival with amplification of the HER-2/neu oncogene显示文摘 | SLAMON D J CLARK G M WONG S G | 1987 | Science1987，235，4785： | 1 |
| 15 | 3D finite element analyses of insertion of the nucleus standard straight and the contour elec- trode arrays into the human cochlea 显示文摘 | Kha H N Chen B K Clark G M | 2007 | J Biomechan2007，40，12： | 1 |
| 16 | Evolution of genes andgenomes on the Drosophila phylogeny显示文摘 | Clark A G Eisen M B Smith D R | 2007 | Nature2007，，： | 1 |
| 17 | Variation in sperm displace- ment and its association with accessory gland protein loci in Drosophila melanogaster显示文摘 | Clark A G Aguad6 M Prout T | 1995 | Genetics1995，139，1： | 1 |
| 18 | The Chitranjan Ranawat Award:Periarticular injections and femoral&sciatic blocks provide similar pain relief after TKA:a randomized clinical trial显示文摘 | Spangehl M J Clarke H D Hentz J G | 2015 | Clin Orthop Relat Res2015，473，1： | 1 |
| 19 | Enhanced cleavage rates following in vitro maturation of pig oocytes within polydimethylsiloxane-borosilicate microchannels 显示文摘 | Hester P N Roseman H M Clark S G | 2002 | Theriogenology2002，57，： | 1 |
| 20 | A solution to the simultaneous localization and map building (SLAM) problem 显示文摘 | M W M Dissanayake G Newman P Clark S | 2001 | IEEE Transactions on Robotics and Automation (SO018-9286)2001，17，3： | 1 |
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