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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Lipidomic analysis of the molecular specificity of a cholinephosphotransferase in situ显示文摘 | FENN H C CLARK G T | 2004 | Biochem Soc Trans2004，32，6： | 1 |
| 3 | High Purity Water Using H2O2 and UV Radiation显示文摘 | CLARKE N KNOWLES G | 1982 | Effluent and Water Treatment Journal1982，，9： | 1 |
| 4 | Pathotyping of Aus- tralian isolates of Marekg disease virus and association of pathogenicity with meq gene polymorphism 显示文摘 | Renz K G Cooke J Clarke N | 2012 | Avian Pathol2012，41，2： | 1 |
| 5 | Somatostation receptor 2 knockout/lacZ knockin mice show impaired motor coordination and reveal sites of somatostation aetion with the striation显示文摘 | Allen JP Hathway G J Clarke N J | 2003 | Eur J Neurosei2003，17，9： | 1 |
| 6 | Influence of bedding type on mucosal immune responses 显示文摘 | Sanford A N Clark S E Talham G | 2002 | Comp Med2002，52，5： | 1 |
| 7 | Evaluation of the antidiabetic activity of DPP Ⅳ resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide显示文摘 | IRWIN N CLARKE G C GREEN B D | 2006 | Biochem Pharmacol2006，72，6： | 1 |
| 8 | Microbiologicai and epidemiological investigation of cholera epidemic in Ukraine during 1994 and 1995显示文摘 | CLARK C G KRAVETZ A N ALEKSEENKO V V | 1998 | Epidemiol Infect1998，121，1： | 1 |
| 9 | 3D finite element analyses of insertion of the nucleus standard straight and the contour elec- trode arrays into the human cochlea 显示文摘 | Kha H N Chen B K Clark G M | 2007 | J Biomechan2007，40，12： | 1 |
| 10 | Three cases of neonatal meningitis caused by Enterobacter sakazakii in powdered milk显示文摘 | BIERING G KARLSSON S CLARK N V C | 1989 | Journal of Clinical Microbiology1989，27，9： | 1 |
| 11 | Enhanced cleavage rates following in vitro maturation of pig oocytes within polydimethylsiloxane-borosilicate microchannels 显示文摘 | Hester P N Roseman H M Clark S G | 2002 | Theriogenology2002，57，： | 1 |
| 12 | School-based primary prevention of depressive symptomatology in adolescents: findings from two studies显示文摘 | Clarke G N Hawkins W Murphy M | 1993 | J Adolesc Res1993，8，2： | 1 |
| 13 | Plateletactivating factor as a potential retrograde messenger in CA1 hippocarmpal long-term potentiation 显示文摘 | KatoK Clark G D Bazan N G | 1994 | Nature1994，867，13： | 1 |
| 14 | A model of urban forest sustainability显示文摘 | CLARK J R MATHENY N P CROSS G | 1997 | J Arboric1997，23，1： | 1 |
| 15 | The role of the thermohaline circulation in abrupt climate change显示文摘 | Clark P U Pisias N G Stocker T F | 2002 | Nature2002，415，6874： | 1 |
| 16 | Emissions Comparisons from Alternative Fuel Buses and Diesel Buses with a Chassis Dynamometer Testing Facility 显示文摘 | Wang W G Clark N N Lyons D W | 1997 | EnvironmentalScience & Technology1997，31，11： | 1 |
| 17 | Healing of an ulnar defect using a proprietary TCP bone graft substitute, JAX, in association with autologous osteogenic cells and growth factors 显示文摘 | Clarke S A Hoskins N L Jordan G R | 2007 | Bone2007，40，4： | 1 |
| 18 | Antioxidants in- hibit proliferation and cell surface expression of receptors for inter- leukin - 2 and transferrin in T lymphocytes stimulated with phorbol myristate acetate and iouomycin 显示文摘 | CHAUDHRI G HUNT N H CLARK I A | 1988 | Cell Immunol1988，115，1： | 1 |
| 19 | Laboratory investigation of hemo- globinopathies and thalassemia review and update显示文摘 | CLARKE G M HIGGINS T N | 2000 | Clin Chem2000，46，8： | 1 |
| 20 | A model of urban forest sustainability 显示文摘 | Clark J R Matheny N P Cross G | 2002 | Journal of Arboriculture2002，23，1： | 1 |
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