|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Using spectral information from the NIR water absorption features for the retrieval of canopy water content 显示文摘 | Clevers J G P W Kooistra L Schaepman M E | 2008 | International Journal of Applied Earth Observation and Geoinformation2008，10，3： | 1 |
| 3 | ,Development and Validation of an Air-to-Beef Food Chain Model for Dioxin-Like Compounds显示文摘 | Lorber M Cleverly D Schaum J | 1994 | The Science of the Total Environment1994，156，： | 1 |
| 4 | Linking colorectal cancer to Wnt signaling 显示文摘 | Bienz M Clevers H | 2000 | Cell2000，103，2： | 1 |
| 5 | The intestinal stem cell显示文摘 | Barker N van de Wetering M Clevers H | 2008 | Genes Dev2008，22，14： | 1 |
| 6 | Influence of Sintering on the Growth Rate of Particu- late Fouling Layers 显示文摘 | Abd-Elhady M S Clevers S H Adriaans T N G et al | 2007 | International Journal of Heat and Mass Transfer2007，50，12： | 1 |
| 7 | Effects of MERIS L1b Radiometric Calibration on Regional Land Cover Mapping and Land Products显示文摘 | Zurita-Milla R Clevers J G P W Schaepman M Kneubuehler M | 2007 | International Journal of Remote Sensing2007，28，34： | 1 |
| 8 | Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix显示文摘 | Van de Wetering M Clevers H | 1992 | EMBO Journal1992，11，： | 1 |
| 9 | Linking colorectal cancer to Wnt signaling 显示文摘 | Bienz M Clevers H | 2000 | Cell2000，103，2： | 1 |
| 10 | Impact and consequences of evapotranspiration changes on water re sources availability in the arid Zhangye Basin, China显示文摘 | Jin X M Schaepman M E Clevers J G P W | 2009 | In- ternational Journal of Remote Sensing2009，30，12： | 1 |
| 11 | Linking colorectal cancer to Wnt signaling显示文摘 | Bienz M Clevers H | 2000 | Cell2000，103，2： | 1 |
| 12 | TCF Transcription factors,mediators of Wnt-signaling in development and cancer显示文摘 | Noort M V Clevers H | 2002 | Developmental Biology2002，244，： | 1 |
| 13 | Hotline update of clinical trials and registries presented at the ACC and SCAI-ACCi2 meeting 2008 in Chicago显示文摘 | Clever YP Rosenkranz S Bohm M | 2008 | Clin Res Cardiol2008，97，7： | 1 |
| 14 | Linking colorectal cancer to Wnt signaling 显示文摘 | Bienz M Clevers H | 2000 | Cell2000，103，2： | 1 |
| 15 | Linking colorectal cancer to Wnt signaling显示文摘 | Bienz M Clevers H | 2000 | Cell2000，103，2： | 1 |
| 16 | Roles of Sox4in central nervous system development显示文摘 | Cheung M Abu-Elmagd M Clevers H | 2000 | Brain Res Mol Brain Res2000，79，12： | 1 |
| 17 | Roles of Sox4 in central nervous system development 显示文摘 | Cheung M Abu-Elmagd M Clevers H | 2000 | Molecular Brain Research2000，79，1： | 1 |
| 18 | Linking colorectal cancer to Wnt signaling显示文摘 | Bienz M Clevers H | 2000 | Cell2000，103，： | 1 |
| 19 | Linking colorectal cancer to Wnt signaling显示文摘 | Bienz M Clevers H | 2000 | Cell2000，103，： | 1 |
| 20 | Linking colorectal cancer to wnt signaling 显示文摘 | BIENA M CLEVERS H | 2000 | Cell2000，103，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员