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| 1 | Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa显示文摘AIM: To define the association between Hashimoto’s thyroiditis and coeliac disease in Dutch patients. METHODS: A total of 104 consecutive patients with Hashimoto’s thyroiditis underwent coeliac serological tests (antigliadins, transglutaminase and endomysium antibodies) and HLA-DQ typing. Small intestinal biopsy was performed when any of coeliac serological tests was positive. On the other hand, 184 patients with coeliac disease were subjected to thyroid biochemical (thyroid stimulating hormone and free thyroxine) and thyroid serological tests (thyroglobulin and thyroid peroxidase antibodies). RESULTS: Of 104 patients with Hashimoto’s thyroiditis, sixteen (15%) were positive for coeliac serology and five patients with documented villous atrophy were diagnosed with coeliac disease (4.8%; 95% CI 0.7-8.9). HLA-DQ2 (and/or -DQ8) was present in all the five and 53 patients with Hashimoto’s thyroiditis (50%; 95% CI 43-62). Of 184 patients with coeliac disease, 39 (21%) were positive for thyroid serology. Based on thyroid biochemistry, the 39 patients were subclassified into euthyroidism in ten (5%; 95% CI 2-9), subclinicalhypothyroidism in seven (3.8%; 95% CI 1.8-7.6), and overt hypothyroidism (Hashimoto’s thyroiditis) in 22 (12%; 95% CI 8-16). Moreover, four patients with coeliac disease had Graves’ disease (2%; 95% CI 0.8-5) and one patient had post-partum thyroiditis. CONCLUSION: The data from a Dutch population confirm the association between Hashimoto’s thyroiditis and coeliac disease. Screening patients with Hashimoto’s thyroiditis for coeliac disease and vice versa is recom- mended. | Muhammed Hadithi Hans de Boer Jos WR Meijer Frans Willekens Jo A Kerckhaert Roel Heijmans Amado Salvador Pea Coen DA Stehouwer Chris JJ Mulder | 2007 | World Journal of Gastroenterology2007，13，11： | 4 |
| 2 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 3 | 二甲双胍长期治疗2型糖尿病患者以及维生素B12缺乏的危险性:随机安慰剂对照研究(摘要)显示文摘目的 研究接受胰岛素治疗的2型糖尿病患者中,二甲双胍所致维生素B12缺乏(〈150pmol/L)、低浓度维生素B12(150—220pmol/L)的发生率,以及叶酸和同型半胱氨酸的浓度。 | Jolien de Jager Adriaan Kooy Philippe Lehert Michiel G Wulffele Jan van der Kolk Daniel Bets Joop Verburg Ab J M Donker Coen D A Stehouwer 许翎岭(译) | 2010 | 英国医学杂志中文版2010，13，5： | 2 |
| 4 | Clogging of biliary endoprosthesis: a new perspective显示文摘 | Coene P Groen A Cheng J | 1990 | Gut1990，31，： | 1 |
| 5 | Particulate deb- ris from a titanium metal prosthesis induces genomic insta- bility in primary human fibroblast cells显示文摘 | Coen N Kadhim M A Wright E G | 2003 | Br J Cancer2003，88，4： | 1 |
| 6 | PET-CT findings in large vessel vasculitis presenting as FUO,a case report显示文摘 | Akin E Coen A Momeni M | | 0，，06： | 1 |
| 7 | The mechanism of galactosamine toxicity revisited;a metabonomic study显示文摘 | COEN M HONG Y S CLAYTON T A | | 0，，： | 1 |
| 8 | Improving HRTEM performance by digital processing of focal image series: Results from the CM20 FEG-Super TWIN显示文摘 | COENE W JANSSEN A J E M op de BEECK M van DYCK D | 1992 | Electron Opt Bull1992，132，： | 1 |
| 9 | Phase retrieval through focus variation for ultra-resolution in field-emission transmission electron microscopy显示文摘 | COENE W JANSSEN A J E M op de BEECK M van DYCK D | 1992 | Phys Rev Lett1992，69，： | 1 |
| 10 | Focal-series reconstruction in HRTEM: Simulation studies on non-periodic objects显示文摘 | THUST A COENE W M J op de BEECK M van DYCK D | 1996 | Ultramicroscopy1996，64，14： | 1 |
| 11 | Supercontinuum generation by stimulated Raman scattering and parametric four-wave mixing in photonic crystal fibers 显示文摘 | Coen S Chau A H L Leonhardt R | 2002 | J Opt Soe Am B2002，19，4： | 1 |
| 12 | Symptoms and patient-reported well-being:do they predict survival in malignant pleuralmesothelioma?A prognostic factor analysis of EORTC-NCIC08983 randomized phase Ⅲ study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma显示文摘 | Bettomley A Coens C Efficace F et el | 2007 | J Clin Oncul2007，25，36： | 1 |
| 13 | Whitelight supercontinuum generation with 60-ps pump pulses in a photonic crystal fiber显示文摘 | Coen S Chau A H L Leonhardt R | 2001 | Opt Lett2001，26，： | 1 |
| 14 | Control of training in middle and long distance running by the indi vidual anaerobic threshold 显示文摘 | COEN B L SCHWARZ A U KINDERMANN W | 1991 | Int j Sport Med1991，，12： | 1 |
| 15 | The potential impact of CTMRI matching on tumor volume delineation in advanced head and neck cancer 显示文摘 | Coen R Ronald K Frank A | 1997 | Int J Radiat Oncol Biol Phys1997，39，4： | 1 |
| 16 | Characterization of soil quality: Physical and chemical criteria 显示文摘 | Arshad M A Coen G M | 1992 | American Journal of Alternative Agriculture1992，7，12： | 1 |
| 17 | In vivo assessment of intact par- athyroid hormone adsorption by different dialysis membranes during hemodialysis 显示文摘 | Baldueci A Coen G Manni M | 2004 | Artif Organs2004，28，12： | 1 |
| 18 | Chemical modification of hydroxyl functions: Introduction of hydrolyzable ester function and bactericidal quaternary ammonium groups显示文摘 | Baudrion F Perichaud A Coen S | 1998 | J Appl Polym Sci1998，70，： | 1 |
| 19 | Development of a screening assay to identify toratogenic and embryotoxic chemicals using the zebrafish embryo 显示文摘 | Selderslaghs I W T Rompay A R V Coen W D | 2009 | Reproductive Toxicology2009，28，3： | 1 |
| 20 | Ben-chamarks achieved in the delivery of radiation therapyfor muscle-invasive bladder cancer 显示文摘 | Coen J J Zietman A L Kaufman I) S ct ai | 2007 | Urol Oncol2007，25，1： | 1 |
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