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| 1 | Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa显示文摘AIM: To define the association between Hashimoto’s thyroiditis and coeliac disease in Dutch patients. METHODS: A total of 104 consecutive patients with Hashimoto’s thyroiditis underwent coeliac serological tests (antigliadins, transglutaminase and endomysium antibodies) and HLA-DQ typing. Small intestinal biopsy was performed when any of coeliac serological tests was positive. On the other hand, 184 patients with coeliac disease were subjected to thyroid biochemical (thyroid stimulating hormone and free thyroxine) and thyroid serological tests (thyroglobulin and thyroid peroxidase antibodies). RESULTS: Of 104 patients with Hashimoto’s thyroiditis, sixteen (15%) were positive for coeliac serology and five patients with documented villous atrophy were diagnosed with coeliac disease (4.8%; 95% CI 0.7-8.9). HLA-DQ2 (and/or -DQ8) was present in all the five and 53 patients with Hashimoto’s thyroiditis (50%; 95% CI 43-62). Of 184 patients with coeliac disease, 39 (21%) were positive for thyroid serology. Based on thyroid biochemistry, the 39 patients were subclassified into euthyroidism in ten (5%; 95% CI 2-9), subclinicalhypothyroidism in seven (3.8%; 95% CI 1.8-7.6), and overt hypothyroidism (Hashimoto’s thyroiditis) in 22 (12%; 95% CI 8-16). Moreover, four patients with coeliac disease had Graves’ disease (2%; 95% CI 0.8-5) and one patient had post-partum thyroiditis. CONCLUSION: The data from a Dutch population confirm the association between Hashimoto’s thyroiditis and coeliac disease. Screening patients with Hashimoto’s thyroiditis for coeliac disease and vice versa is recom- mended. | Muhammed Hadithi Hans de Boer Jos WR Meijer Frans Willekens Jo A Kerckhaert Roel Heijmans Amado Salvador Pea Coen DA Stehouwer Chris JJ Mulder | 2007 | World Journal of Gastroenterology2007，13，11： | 4 |
| 2 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 3 | Endothelial dysfunction in diabetic nephropathy:state of the art and potential significance for non-diabetic renal disease显示文摘 | Coen DA | 2004 | Nephrol Dial Transplant2004，19，： | 1 |
| 4 | Serum homocysteine and risk of coronary heart disease and cerebrovascular disease in elderly men显示文摘 | Coen DA Stehuwer Matty | 1998 | A rteriosclerosis Thrombosis and Vascular Biology1998，18，： | 1 |
| 5 | Serum homocysteine and risk factor of coronary heart disease and cerebrovascular disease in elderly men 显示文摘 | Coen DA Stehouwr M | 1998 | Arteriosclerosis Thrombosis and Vascular Biology1998，18，： | 1 |
| 6 | Control of Organ Asymmetry in Flowers of Antirrhinum显示文摘 | Da Luo Rosemary Carpenter Lucy Copsey Coral Vincent Jennifer Clark Enrico Coen | | Cell0，，： | 1 |
| 7 | Endothelial dysfunction in diabetic nephropathy: state of the art and potential significance for non-diabetic renal disease显示文摘 | Coen DA | 2004 | Nephrol Dial Translant2004，19，： | 1 |
| 8 | Serum hmocysteine and risk of coronary heart disease and cerebroascular disease in elderly men显示文摘 | Coen DA Stehuwer Matty | 1998 | Arteriosclerosis Thrombosis and Vasoular Biology1998，18，： | 1 |
| 9 | Vascular complications in diabetes mellitus:the role of endothelial dysfunction显示文摘 | Casper G Coen DA | 2005 | Clinical Science2005，109，： | 1 |
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