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| 1 | 国际疼痛研究协会疼痛定义修订版:概念、挑战和折中显示文摘现行国际疼痛研究协会(IASP)将疼痛定义为'与实际或潜在组织损伤,或描述的类似损伤相关的一种不愉快的感觉和情感体验',该定义是由一个分类小组委员会推荐,并于1979年被IASP理事会所采纳。这一定义已被疼痛领域的卫生保健专业人士和研究人员广泛接受,并被一些行业、政府及非政府组织(包括世界卫生组织)所采用。近年来,一些业内人士认为,随着对疼痛更深入的了解,有必要对这个定义重新审定,并提出了修改建议。因此,2018年,IASP成立了一个主席特别工作小组,该小组是由14名来自多个国家的在疼痛相关的临床和基础科学方面拥有广泛专业知识的人员组成,其任务是评估现行定义及其附带注释,并对其保留还是修改提出建议。本文提供了关键概念的摘要、对IASP会员和公众评论的分析以及两年内委员会对疼痛定义和注释的最终修订意见。特别工作小组最后建议将疼痛定义修改为'与组织损伤或潜在组织损伤相关或类似相关的一种不愉快的感觉和情感体验',并将原来的附带注释更新为一系列简要说明并提供相关词源。今年年初,IASP理事会一致接受了修订后的定义和注释。 | Raja SN.Carr DB Cohen M.Finnerup NB Flor H.Gibson S Keefe FJ.Mogil JS Ringkamp M.Sluka KA Song XJ.Stevens B Sullivan MD.Tutelman PR Ushida T.Vader K 程志祥(译) 许继军(译) 程建国(审校) 刘先国(审校) 刘延青(审校) | 2020 | 中华疼痛学杂志2020，16，5： | 137 |
| 2 | Determinants of environmental innovation in US manufacturing industries显示文摘 | Smita B Brunnermeier Mark A Cohen | 2003 | Journal of Environmental Economics and Management2003，，2： | 6 |
| 3 | Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers显示文摘AIM:To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori(H.pylori)-associated,non-steroidal inflammatory drug(NSAID)-associated and idiopathic-gastric ulcers.METHODS:We studied a cohort of randomly selected patients with H.pylori(group 1,n=30),NSAID(group 2,n=18),combined H.pylori and NSAID associated gastric ulcers(group 3,n=24),and patients with idiopathic gastric ulcers(group 4,n=20).Immunohistochemistry for MUC1,MUC4,MUC17,and staining for Erythrina cristagalli agglutinin and Sambucus nigra agglutinin(SNA)lectins was performed on sections from the ulcer margins.RESULTS:Staining intensity of MUC17 was higher in H.pylori ulcers(group 1)than in idiopathic ulcers(group4),11.05±3.67 vs 6.93±4.00 for foveola cells,and10.29±4.67 vs 8.00±3.48 for gland cells,respectively(P<0.0001).In contrast,MUC1 expression was higher in group 4 compared group 1,9.89±4.17 vs 2.93±5.13 in foveola cells and 7.63±4.60 vs 2.57±4.50 for glands,respectively(P<0.0001).SNA lectin staining was increased in group 4,in parallel to elevated MUC1expression,indicating more abundantα2-6 sialylation in that group.CONCLUSION:Cytoplasmic MUC17 staining was sig-nificantly decreased in the cases with idiopathic ulcer.The opposite was observed for both MUC1 and SNA lectin.This observation may reflect important pathogenic mechanisms,since different mucins with altered sialylation patterns may differ in their protection efficiency against acid and pepsin. | Yaron Niv Doron Boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K Batra Samuel B Ho | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 4 | Hyperspectral versus multispectral data for estimating leaf area index in four different biomes显示文摘 | Kyu-Sung Lee Warren B Cohen Robert E Kennedy Thomas K Maiersperger Stith T Gower | 2004 | Remote Sensing of Environment2004，，3： | 2 |
| 5 | DAP kinase links the control of apoptosis to metastasis显示文摘 | Inbal B Cohen O Polak-Charcon | 1997 | Nature1997，390，： | 1 |
| 6 | Should you cancel the operation when a child has an upper respiratory tract infection?显示文摘 | COHEN M M CAMERON C B | 1991 | Anesth Analg1991，72，： | 1 |
| 7 | Verbs and Adverbs:Multidimensional Motion Interpolation 显示文摘 | Rose C E Cohen M Bodenheimer B | 1998 | IEEE Computer Graphics & Application (S0272-1716)1998，18，5： | 1 |
| 8 | Differential mechanisms of microparticle transfer to B cells and monocytes: anti-inflamma- tory properties of micropartieles显示文摘 | Koppler B Cohen C Schlondorff D | 2006 | Eur J Immunol2006，36，3： | 1 |
| 9 | Endotoxin removal devices for thetreatment of sepsis and septic shock 显示文摘 | DAVIES B COHEN J | 2011 | Lancet Infect Dis2011，11，1： | 1 |
| 10 | Systemic fea- tures of immune recognition in the gut显示文摘 | SWIATCZAK B RESCIGNO M COHEN I R | 2011 | Microbes Infect2011，13，1213： | 1 |
| 11 | Spectacle independence and subjective satisfaction of Re STOR multifoeal intraoeular lens after cataract or presbyopia surgery in two European eountries显示文摘 | Cohener B Fernandez-Vega L Alfonso JF | 2010 | Clin Ophthalmol2010，4，： | 1 |
| 12 | Fuel/cladding compatibility in U-19Pu-10Zr/HT9-clad fuel at elevated temperature显示文摘 | Cohen A B Tsai H Neimark L A | | 0，，： | 1 |
| 13 | Complex dynamics and synchroniza tion of delayed-feedback nonlinear oscillators显示文摘 | Murphy T E Cohen A B Ravoori B | 2010 | Philosophical Transactions of the Royal Society A-Mathematical Physical and Engineering Sciences2010，368，1911： | 1 |
| 14 | Robotic positioning of standard electro- physiology catheters : a novel approach to catheter robotics 显示文摘 | Knight B Ayers GM Cohen TJ | 2008 | J lnva- sire Cardio12008，20，5： | 1 |
| 15 | Inequities in Hospital Care, the Massachusetts Experience显示文摘 | Young G J Cohen B B | 1991 | Inquiry1991，，28： | 1 |
| 16 | Determinants of Environmental Innovation in US Manufacturing Industries显示文摘 | Brunnermeier S B Cohen M A | 2003 | Journal of Environmental Economics and Management2003，45，2： | 1 |
| 17 | Operational strategies to achieve and maintain malaria elimination 显示文摘 | Mooner B Cohen JM Snovo KW | 2010 | Lancet2010，376，9752： | 1 |
| 18 | Who underreacts to cash-flow news? Evidence from trading between individuals and institutions显示文摘 | Cohen R B Gompers P A Vuolteenaho T | 2002 | Journal of financial Economics2002，66，2： | 1 |
| 19 | Speech enhancement for non-stationary noise environments显示文摘 | COHEN I BERDUGO B | 2001 | Signal Processing2001，81，2： | 1 |
| 20 | Genetic and functional analysis of the multiple antibiotic resistance (mar) loeus in Escherichia coli显示文摘 | Cohen S P Hachler H Levy S B | 1993 | J Baeteriol1993，175，5： | 1 |
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