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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Novel Brφ nsted acidic ionic liquids and their use as dualsolventcatalysts显示文摘 | Amanda C Cole Jessica L Ioanna Ntai | 2002 | J Am Chem Soc2002，124，： | 1 |
| 3 | Use of biosolids in the forest: Technology, economics and regulations显示文摘 | HENRY C L COLE D W | 1997 | Biomass and Bioenergy1997，13，4： | 1 |
| 4 | Novel bronsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | Cole A C Jensen J L Ntai I | 2002 | Journal of the American Chemical Society2002，124，21： | 1 |
| 5 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 6 | 查看详情显示文摘 | Cole A C Jensen J L Ntai I Tran K L T Weaver K J Forbes D C Davis J H Jr | | 0，，： | 1 |
| 7 | Dutch techniques for the establishment of natural plant communities in urban areas显示文摘 | COLE l KEEN C | 1976 | Landscape Design1976，116，： | 1 |
| 8 | Novel Bronsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | COLE A C JENSEN J L NTAI I | 2002 | Journal of the American Chemical Society2002，124，21： | 1 |
| 9 | J Am Chem Soc显示文摘 | Cole A C Jensen J L Ntai I | 2002 | 124:5962-59632002，124，： | 1 |
| 10 | Lipid and carbon isotopic evidence of methane-oxidizing and sulfatereducing bacteria in association with gas hydrates from the Gulf of Mexico显示文摘 | Zhang C L Li Y Wall J D Wall J D Larsen L Sassen R Huang Y Wang Y Peacock A White D C Horita J and Cole D R | | 0，，： | 1 |
| 11 | Novel brφnsted acidic ionic liquids and their use as dual solvent-catalysts 显示文摘 | Cole A C Jensen J L Ntai I | 2002 | J Am Chem Soc2002，124，： | 1 |
| 12 | Rare-earth doped selenide glasses for active applications in the near and mid-IR 显示文摘 | COLE B SHAW L B PUREZA P C | 1999 | J Non-Cryst Solids1999，，： | 1 |
| 13 | Fatty acid transporterlevels and palmitate oxidation rate correlate with ejection fraction inthe infarcted rat heart显示文摘 | Heather L C Cole M A Lygate C A | 2006 | Cardiovasc Res2006，72，3： | 1 |
| 14 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A Mclean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG | 1998 | Nature1998，393，6685： | 1 |
| 15 | Novel Brφnsted Acidic Ionic Liquids and Their use as Dual Solvent-catalysts显示文摘 | Cole A C Jensen J L Ntai I | 2002 | J Am Chem Soc2002，124，59： | 1 |
| 16 | Novel Br6nsted Acidic Ionic Liquids and Their Use as Dual Solvent-Catalysts显示文摘 | Cole A C Jensen J L Ntai I | 2002 | J Am Chem Soc2002，124，21： | 1 |
| 17 | Indicators of human health in ecosystems:what do we measure显示文摘 | Donald C Cole John Eyles Brian L Gibson | 1998 | The Science of the Total Environment1998，224，： | 1 |
| 18 | Cultural Differences in Children's Emotional Reactions to Difficult Situations 显示文摘 | Cole P M Bruschi C J Tamang B L | 2002 | Child Development2002，73，3： | 1 |
| 19 | Novel bronsted acidic ionic liquids and their use as dual solvent catalysts 显示文摘 | Cole Amanda C Jensen Jessica L Ntai ioarma | 2002 | J Am Chem Soc2002，124，21： | 1 |
| 20 | Highly efficient formation of visible light tunable TiO2 - x Nx photocatalysts and their trans- formation at the nanoscale 显示文摘 | Cole J L Stout J D Burda C | 2004 | J Phys Chem B2004，108，4： | 1 |
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