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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 3 | 临床实践指南应当包含治疗负担显示文摘医疗方案的实施需要花费大量时间和精力,给慢性病患者带来巨大负担。然而,临床实践指南高度重视的是得到某些临床结果(如呼吸急促减少或存活率增加),传统指南的建议也是从同样角度提出的。最近的指南会考虑患者的价值观以及指南建议行为的可接受性和可行性,但对治疗负担没有明确规定。这使患者很难根据自己的价值观和能力对治疗做出明智的决定。 | Claudia C Dobler Nathan Harb Catherine A Maguire Carol L Armour Courtney Coleman M Hassan Murad 邓璇(译) 莫云凌(校) | 2019 | 英国医学杂志中文版2019，22，3： | 3 |
| 4 | Let the soil work for us显示文摘 | Elliott E T Coleman D C | 1988 | Ecological Bulletins1988，39，： | 2 |
| 5 | Safety and efficacy of sofosbuvir/velpatasvir/voxilaprevir in postliver transplant patients with previous direct-acting antiviral failure:Six case reports显示文摘BACKGROUND Direct-acting antiviral(DAA)therapy regimens are highly effective at eliminating hepatitis C virus(HCV)infection but rates of sustained virologic response(SVR)are lower in patients with decompensated cirrhosis or hepatocellular carcinoma.Since many of these patients will be referred for liver transplant,they will require retreatment after transplantation.Sofosbuvir/velpatasvir/voxilaprevir(SOF/VEL/VOX)is recommended by guidelines as the preferred regimen to treat HCV in DAA-experienced patients following liver transplant however there is limited data.CASE SUMMARY We present the cases of six liver transplant recipients who had previous treatment failure with sofosbuvir-based DAA therapy prior to transplantation and who then received SOF/VEL/VOX after transplant.CONCLUSION This case series demonstrate the real-world efficacy and safety of SOF/VEL/VOX in the post liver transplant setting.Treatment was successful with all patients achieving SVR,it was well tolerated,and there were minimal drug-drug interactions with their immunosuppressants. | Cory Higley Christine C Hsu Coleman Smith Sandeep Nadella Alexander T.Lalos | 2020 | World Journal of Hepatology2020，12，12： | 2 |
| 6 | Selective interaction of a semiconjugated organic polymer with single-wall nanotubes 显示文摘 | Dalton A Stephan C Coleman J N | 2000 | J Phys Chem B2000，104，10： | 1 |
| 7 | Otolith-fish size relationship in juvenile gag (Mycteroperca microlepis ) of the eastern Gulf of Mexico : a comparison of growth rates between laboratory and field populations 显示文摘 | Strelcheck A J Fitzhugh G R Coleman F C | 2003 | Fish Res2003，60，： | 1 |
| 8 | Further assess- ment of a three-component model of occupational commitment: generalize ability and differences across occupations显示文摘 | IRVING P G COLEMAN D F COOPER C L | 1997 | J Ap- plied Psychol1997，82，3： | 1 |
| 9 | Image Segmentation by clustering显示文摘 | Coleman G Andrews H C | 1979 | Proceedings of the IEEE1979，67，5： | 1 |
| 10 | Investigation of simulated annealing,ant-colony optimization,and genetic algorithms for self-structuring antennas显示文摘 | COLEMAN C M ROTHWELL E J ROSS J E | 2004 | IEEE Transactions on Antennas and Propagation2004，52，4： | 1 |
| 11 | Impact of a national external quality assessment scheme for breast pathology in the UK显示文摘 | Ellis IO Coleman D Wells C | 2006 | Clin Pathol2006，59，2： | 1 |
| 12 | Interleukin 6:an autocrine regulator of mesangial cell growth显示文摘 | Coleman DL Ruef C | 1992 | Kidney Int1992，41，3： | 1 |
| 13 | Investigation of Simulated Annealing, Ant-Colony Optimization, and Genetic Algo- rithms for Self-structuring Antennas显示文摘 | Coleman C M Rothwell E J Ross J E | 2004 | IEEE Trans on AP2004，52，4： | 1 |
| 14 | Improving the quality of transi- tional care for persons with complex care needs显示文摘 | Coleman E A Boult C | 2003 | J AmGeriatr Soc2003，51，4： | 1 |
| 15 | Recovery of motor function after spinal cord injury--a randomized,placebo-controlled trial with GM-1 ganglioside显示文摘 | GEISLER F H DORSEY F C COLEMAN W P | | 0，，26： | 1 |
| 16 | Glycogen storage disease in adults显示文摘 | Talente GM Coleman RA Alter C | 1994 | Ann Intern Med1994，120，： | 1 |
| 17 | The Care Transitions Intervention显示文摘 | Coleman EA Parry C Chalmers S | 2006 | Areh Intern Med2006，166，： | 1 |
| 18 | Responses of trophic groups of soil nematodes to residue application under conventional tillage and no- till regimes 显示文摘 | Fu S L Coleman D C Hendrix P F | 2000 | Soil Biology and Biochemistry2000，32，： | 1 |
| 19 | Water- stable aggregates and organic matter fractions in conventional and notillage soils 显示文摘 | BEARE M H HENDRIX P F COLEMAN D C | 1994 | Soil Science Society of America Journal1994，58，3： | 1 |
| 20 | Immunoassay detection of hepatitis B surface antigen mutants显示文摘 | COLEMAN P F CHEN Y C MUSHAHWAR I K | 1999 | J Med Virol1999，59，： | 1 |
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