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| 1 | Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients显示文摘AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank < 50 g ethanol/day. Diverse SNPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP a.RESULTS A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. None of the six SNPs evaluated had any significant association with liver fibrosis ≥ F2.CONCLUSION Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection. | Julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina Angel-Hugo Montes José A Cartón Víctor Asensi | 2017 | World Journal of Virology2017，6，2： | 3 |
| 2 | Subsets of myeloid-de- rived suppressor cells in tumor-bearing mice 显示文摘 | Youn JI Nagaraj S Collazo M | 2008 | J Immunol2008，181，8： | 1 |
| 3 | Subsets of myeloid-derived suppressor cells in tumor-bearing mice 显示文摘 | Youn JI Nagaraj S Collazo M | 2008 | J Immunol2008，181，8： | 1 |
| 4 | Subsets of myeloid derived suppressor cells in tumor-bearing mice 显示文摘 | Youn JI Nagaraj S Collazo M | 2008 | J Immuno12008，181，8： | 1 |
| 5 | Subsets of myeloidderived suppressor cells in tumor-bearing mice显示文摘 | Youn JI Nagaraj S Collazo M | 2008 | J Immunol2008，181，8： | 1 |
| 6 | Subsets of myeloid-derived suppressor cells in tumor-bearing mice显示文摘 | YOUN J I NAGARAJ S COLLAZO M | 2008 | J Immunol2008，181，8： | 1 |
| 7 | Subsets of myeloid-derived suppressor cells in Tumor-Bearing Mice1显示文摘 | Youn J I Nagaraj S Collazo M | 2008 | Blood2008，112，2： | 1 |
| 8 | Subsets of myeloid-derived suppressor cells in tumor-bearing mice显示文摘 | Youn Jl Nagaraj S Collazo M | 2008 | J lmmunol2008，181，8： | 1 |
| 9 | Subsets of myeloid-derived suppressor cells in tumor-bearing mice 显示文摘 | Youn JI Nagaraj S Collazo M Gabrilovich DI | 2008 | J Immunol2008，181，8： | 1 |
| 10 | Subsets of myeloid-derived suppressor cells in tumor-bearing mice 显示文摘 | Youn J I Nagaraj S Collazo M | 2008 | J Immunol2008，181，8： | 1 |
| 11 | Subsets of myeloid-derived suppressor cells in tumor-bearing mice显示文摘 | YOUN J I NAGARAJ S COLLAZO M | 2008 | J Immunol2008，181，8： | 1 |
| 12 | Subsets of myeloid-derived suppressor cells in tumor bearing mice 显示文摘 | Youn JI Nagaraj S Collazo M et 81 | 2008 | J Immunol2008，181，8： | 1 |
| 13 | Subsets of myeloid-derived suppressor ceils in tumor-beating mice 显示文摘 | Youn JI Nagaraj S Collazo M | 2008 | J Immunol2008，181，8： | 1 |
| 14 | Regulatory mycluid sup- pressor cells in heahh and disease 显示文摘 | Nagaraj S Collazo M Corzo C A | 2009 | Cancer Res2009，69，19： | 1 |
| 15 | Subsets of myeloid-derived suppressor cells in tumor-bearing mice显示文摘 | YounJI Nagaraj S Collazo M | 2008 | J Immunol2008，181，8： | 1 |
| 16 | Subsets of myeloid-derived suppressor cells in tumor-bearing mice 显示文摘 | YOUN J I NAGARAJ S COLLAZO M | 2008 | J Immunol2008，181，8： | 1 |
| 17 | Subsets of myeloid-derived suppressor ceils in tumor-beating mice 显示文摘 | Youn JI Nagaraj S Collazo M | 2008 | Immunol2008，181，8： | 1 |
| 18 | The function of gamma intefferon-γinducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Statl dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments 显示文摘 | Collazo CM Yap GS Hieny S | 2002 | Infect Immun2002，70，： | 1 |
| 19 | Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice 显示文摘 | Youn Jl Nagaraj S Collazo M | 2008 | The Journal of Immunology2008，181，： | 1 |
| 20 | Subsets of myeloidderived suppressor cells in tumor-bearing mice显示文摘 | Youn JI Nagaraj S Collazo M | 2008 | J Immunol2008，181，8： | 1 |
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