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191篇 您的检索式：作者名="Collins T E"

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	题名	作者	年代	出处	被引量
1	The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients.	Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens	2016	Bone Research2016，4，2：	6
2	Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘	Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A.	2009	中国神经肿瘤杂志2009，7，4：	3
3	CD133,a novel marker for human prostatic epithelial stem cells显示文摘	Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T	2004	J Cell Sci2004，117，16：	1
4	Isolation of swine infertility and respiratory syndrome virus(isolate ATCC VR-2332)in North America and experimental reproduction of the disease in gno-tobiotic pigs 显示文摘	Collins J E Benfield D A Christianson W T	1992	Journal of Veterinary Diagnostic Investigation1992，4，2：	1
5	Soil carbon pools and fluxes in lung-term corn belt agroeeosystems 显示文摘	COLLINS H P ELLIOTT E T PAUSTIAN K	2000	Soil Biology and Biochemistry2000，32，2：	1
6	Iso-lation of swine infertility and respiratory syndrome vi-rus (isolate ATCC VR22332) in North America andexperimental reproduction of the disease in gnotobiot-ic pigs显示文摘	Collins J E Benfield D A Christianson W T	1992	Vet Diagn Invest1992，4，2：	1
7	Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR- 2322) in North America and experiment reproduction of the disease in gnotobiotie pigs显示文摘	Collins J E Benfield D A Christianmn W T	1992	J Vet Diagn Invest1992，4，2：	1
8	Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs显示文摘	Collins J E Benfield D A Christianson W T	1992	J Vet Diagn Invest1992，4，：	1
9	miR-19a:an effective regula-tor of SOCS3 and enhancer of JAK-STAT signalling显示文摘	Collins A S McCoy C E Lloyd A T	2013	PLoS One2013，8，69：	1
10	Insolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332)in North America and experimental reproduction of the disease in gnotobiotic pigs显示文摘	Collins J E Benfild D A Christianson W T	1992	J Vet Diagn Invest1992，，4：	1
11	Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs 显示文摘	Collins J E Benfield D A Christianson W T	1992	J Vet Diagn Invest1992，4，2：	1
12	Experimental reproduction of swine infertility and respiratory syndrome in pregnant sows显示文摘	Christianson W T Collins J E Benfield D A		0，，：	1
13	Optimizing electropo-ration conditions in primary and other difficult-to-transfectcells显示文摘	Jordan E T Collins M Terefe J	2008	Journal of Biomolecular Techniques2008，19，5：	1
14	Change in knee carti- lage Tz at MR imaging after running: a feasibility study显示文摘	Mosher T J Smith H E Collins C	2005	Radi- ology2005，234，1：	1
15	查看详情显示文摘	Landen O L Boehly T R Bradley D K Braun D G Callahan D A Celliers P M Collins G W Dewald E L Divol L Glenzer S H Hamza A Hicks D G Hoffman N Izumi N Jones O S Kirkwood R K Kyrala G A Michel P Milovich J Munro D H Nikroo A Olson R E Robey H F Spears B K Th		0，，：	1
16	Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs显示文摘	Collins J E Benfield D A Christianson W T	1992	JVet Diagn Invest1992，4，2：	1
17	The effect of atmosphere and ZnO morphology on the performance of hybrid Poly(3-hexylthiophene)/ZnO nanofiber photovoltaic devices显示文摘	Olson D C Shaheen S E Collins R T	2007	J Phys Chem C2007，111，16：	1
18	Bale density and moisture effects on alfalfa round bale silage显示文摘	Han K J Collins M Vanzant E S Dougherty C T	2004	Crop Sci2004，44，3：	1
19	Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs显示文摘	COLLINS J E BENFIELD D A CHRISTIANSON W T	1992	J Vet Diagn Invest1992，4，2：	1
20	An additive interaction between the NFB and estrogen receptor signalling pathways in human endometrial epithelial cells 显示文摘	King A E Collins F Klonisch T	2010	Hum Reprod2010，25，：	1

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