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| 1 | Evaluating alternative stem cell hypotheses for adult corneal epithelial maintenance显示文摘In this review we evaluate evidence for three different hypotheses that explain how the corneal epithelium is maintained. The limbal epithelial stem cell(LESC)hypothesis is most widely accepted. This proposes that stem cells in the basal layer of the limbal epithelium, at the periphery of the cornea, maintain themselves and also produce transient(or transit) amplifying cells(TACs). TACs then move centripetally to the centre of the cornea in the basal layer of the corneal epithelium and also replenish cells in the overlying suprabasal layers. The LESCs maintain the corneal epithelium during normal homeostasis and become more active to repair significant wounds. Second, the corneal epithelial stem cell(CESC) hypothesis postulates that, during normal homeostasis, stem cells distributed throughout the basal corneal epithelium, maintain the tissue. According to this hypothesis, LESCs are present in the limbus but are only active during wound healing. We also consider a third possibility, that the corneal epithelium is maintained during normal homeostasis by proliferation of basal corneal epithelial cells without any input from stem cells. After reviewing the published evidence, we conclude that the LESC and CESC hypotheses are consistent with more of the evidence than the third hypothesis, so we do not consider this further. The LESC and CESC hypotheses each have difficulty accounting for one main type of evidence so we evaluate the two key lines of evidence that discriminate between them. Finally, we discuss how lineage-tracing experiments have begun to resolve the debate in favour of the LESC hypothesis. Nevertheless, it also seems likely that some basal corneal epithelial cells can act as long-term progenitors if limbal stem cell function is compromised. Thus, this aspect of the CESC hypothesis may have a lasting impact on our understanding of corneal epithelial maintenance, even if it is eventually shown that stem cells are restricted to the limbus as proposed by the LESC hypothesis. | John D West Natalie J Dorà J Martin Collinson | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | F0 membrane domain of ATP synthase from bovine heart mitochondria:purification subunit composition and reconstitution with F1-ATPase 显示文摘 | COLLINSON L R RUNSWICK M J BUCHANAN S K | 1994 | Biochem1994，33，25： | 1 |
| 3 | DNA-based diagnostic tests for Salmonella species targeting agfA,the structural gene for thin,aggregative fimbriae显示文摘 | DORAN J L COLLINSON S K BURIAN J | 1993 | J Clin Microbiol1993，31，： | 1 |
| 4 | A ditopic ferrocene receptor for anions and cations that functions as a chromogenic molecular switch显示文摘 | M(YAJI H coLLINSON S R TUCKER J H R | 2003 | Chem Commun2003，6465，： | 1 |
| 5 | Amino termina 1 pro-B-type natriuretic peptide: analytic considerations 显示文摘 | Ordonez-Llanos J Collinson PO Christenson RH | 2008 | Am J Cardiol2008，101，3： | 1 |
| 6 | Multicentre evaluation of the diagnostic value of cardiac troponin-T,CK-MB mass,and myoglobin for assessing patients with suspected acute coronary syndromes in routine clinical practice显示文摘 | COLLINSON P O STUBBS P J KESSLER AC | 2003 | Heart2003，89，3： | 1 |
| 7 | Corneal abnormalities in Pax6 small eye mice mimic human aniridia-related keratopathy 显示文摘 | Ramaesh T Collinson J M Ramaesh K | 2003 | Invest Ophthalmol Vis Sci2003，44，： | 1 |
| 8 | Radiation dose to the respiratory system due to radon and its daughter products显示文摘 | HAQUE A COLLINSON A J L | 1967 | Health Physics1967，13，5： | 1 |
| 9 | Experiments in water logging and sedimentology of charcoal: results and implications 显示文摘 | Nichols G J Cripps J A Collinson M E | 2000 | Palaeogeogr Palaeoclimatol Palaeoecol2000，164，： | 1 |
| 10 | Thin aggregativefimbriae mediate binding of Salmonella enteritidis to fibronecan显示文摘 | Collinson K S Doig P C Doran J L | 1993 | J Bacteriol1993，175，： | 1 |
| 11 | High efficiency gene replacement in Salmonella enteritidis:chimeric fimbrins conraining a T-cell epitope from Leishmania major显示文摘 | WHITE A P COLLINSON S K BURIAN J | 1999 | Vaccine1999，17，： | 1 |
| 12 | Uhra rigid cross-bridged tetraazamacrocycles as ligands--the challenge and the solution显示文摘 | HUBIN T J MCCORMICK J M COLLINSON S R | 1998 | Chemical Communications1998，34，16： | 1 |
| 13 | Are troponins confusing?显示文摘 | COLLINSON P O STUBBS P J | 2003 | Heart2003，89，11： | 1 |
| 14 | Amino-ter- minal pro-B-type natriuretic peptide: analytic consider- ations显示文摘 | Ordonez-Llanos J Collinson PO Christenson RH | 2008 | Am J Cardiol2008，101，3： | 1 |
| 15 | Structural predictions of AgfA,the insoluble fimbrial subunit of Salmonella thin aggregative fimbriae显示文摘 | COLLINSON S K PARKER J M HODGES R S | | J Mol Biol0，290，： | 1 |
| 16 | Power quality显示文摘 | Stones J Collinson A | 2001 | Power Engineering Journal2001，15，2： | 1 |
| 17 | A modeling and simulation study of siderophore mediated antagonism in dual-species biofilms 显示文摘 | Eberl H J Collinson S | 2009 | Theoretical Biology and Medical Modelling2009，6，1： | 1 |
| 18 | Diagnos- tic and prognostic role of cardiac troponin I(cTnI) measured on the DPC Immulite显示文摘 | Collinson PO Gaze DC Stubbs P J | 2006 | Clin Biochem2006，39，7： | 1 |
| 19 | Thin aggregative fimbriae from diarrheagenic Escherichia coli 显示文摘 | Collinson S K Emody L Trust T J | 1992 | J Bacteriol1992，174，： | 1 |
| 20 | MuUicenter analytical performance evaluation of the Elecsys proBNP assay显示文摘 | SOKOLL L J BAUM H COLLINSON P O | 2004 | Clin Chem Lab Med J2004，42，8： | 1 |
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