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| 1 | Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery显示文摘AIM: To evaluate the surface expression of triggering receptor on myeloid cell 1 (TREM-1), class Ⅱ major histocompatibility complex molecules (HLA-DR), andthe expression of the splicing variant (svTREM-1) ofTREM-1 in septic patients and those subjected to major abdominal surgery.METHODS: Using flow cytometry, we examined the surface expression of TREM-1 and HLA-DR in peripheral blood monocytes from 11 septic patients, 7 elective gastrointestinal surgical patients, and 10 healthy volunteers. svTREM-1 levels were analyzed by RT-PCR. RESULTS: Basal expression of TREM-1 and HLA-DR in healthy volunteers was 35.91±14.75 MFI and75.8±18.3%, respectively. In septic patients, TREM-1 expression was 59.9±23.9 MFI and HLA-DR expression was 44.39±20.25%, with a significant differencebetween healthy and septic groups (P<0.05) for bothmolecules. In the surgical patients, TREM-1 and HLA-DR expressions were 56.8±20.85 MFI and 71±13.8% before surgery and 72.65±29.92 MlFI and 72.82±22.55% after surgery. TREM-1 expression was significantly different(P = 0.0087) between the samples before and aftersurgery and svTREM-1 expression was 0.8590±0.1451 MF1, 0.8820±0.1460 MF1, and 2.210±0.7873MF1 in the healthy, surgical (after surgery) and septic groups, respectively. There was a significant difference (P = 0.048) in svTREM-1 expression between the healthy and surgical groups and the septic group.CONCLUSION: TREM-1 expression is increased during systemic inflammatory conditions such as sepsis and the postoperative phase. Simultaneous low expression of HLA-DR molecules correlates with the severity of illness and increases susceptibility to infection. Additionally, TREM-1 expression is distinctly different in surgical patients at different stages of the inflammatory response before and after surgery. Thus, surface TREM-1 appears to be an endogenous signal during the course of the inflammatory response. svTREM-1 expression is significantly increased during sepsis, appearing to be an indicator of severity of illness. Together, these data indicate that TREM-1 may play an important role in establishing and amplifying the systemic inflammatory response. TREM-1, HLA-DR, and svTREM-1 expression analysis can provide useful diagnostic and prognostic indicators during SIRS, CARS, and sepsis. | Nestor González-Roldán Eduardo Ferat-Osorio Rosalía Aduna-Vicente Isabel Wong-Baeza Noemí Esquivel-Callejas Horacio Astudillo-de la Vega Patricio Sánchez-Fernández Lourdes Arriaga-Pizano Miguel Angel Villasís-Keever Constantino López-Macías Armando Isibasi | 2005 | World Journal of Gastroenterology2005，11，47： | 9 |
| 2 | Prognostic factors and time-related changes influence results of colorectal liver metastases surgical treatment:A single-center analysis显示文摘AIM:To analyze the prognostic factors involved in survival and cancer recurrence in patients undergoing surgical treatment for colorectal liver metastases(CLM) and to describe the effects of time-related changes on survival and recurrence in these patients.METHODS:From January 1994 to January 2006,236 patients with CLM underwent surgery with the aim of performing curative resection of neoplastic disease at our institution and 189(80%) of these patients underwent resection of CLM with curative intention.Preoperative,intraoperative and postoperative data,including primary tumor and CLM pathology results,were retrospectively reviewed.Patients were divided into two time periods:a first period from January 1994 to January 2000(n = 93),and a second period from February 2000 to January 2006(n = 143).RESULTS:Global survival at 1,3 and 5 years in patients undergoing hepatic resection was 91%,54% and 47%,respectively.Patients with preoperative extrahepatic disease,carcinoembryonic antigen(CEA) levels over 20 ng/dL,more than four nodules or extrahepatic invasion at pathological analysis had worse survival.Tumor recurrence rate at 1 year was 48.3%,being more frequent in patients with preoperative and pathological extrahepatic disease and CEA levels over 20 ng/dL.Although patients in the second time period had more adverse prognostic factors,no differences in overall survival and recurrence were observed between the two periods.CONCLUSION:Despite advances in surgical technique and better adjuvant treatments and preoperative imaging,careful patient staging and selection is crucial to continue offering a chance of cure to patients with CLM. | Josep Martí María Marta Modolo Josep Fuster Jaume Comas Rebeca Cosa Joana Ferrer Victor Molina Juan Romero Constantino Fondevila Ramón Charco Juan Carlos García-Valdecasas | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 3 | Spectroscopic characterization of doped poly(benzidine) and its nanocomposite with cationic clay显示文摘 | Gustavo M do Nascimento Vera R L Constantino Marcia L A Temperini | 2004 | Journal of Physical Chemistry B2004，108，18： | 1 |
| 4 | Yaenia solium cysticercosis: lymphocytes in the inflammatory reaction in naturally infected pigs显示文摘 | PEREZ-TORRES A USTARROZ M CONSTANTINO F | 2002 | Parasitol Res2002，88，2： | 1 |
| 5 | Relation between red blood cell distribution width and ischemic stroke: a case‐control study显示文摘 | Jose M. Ramírez‐Moreno María Gonzalez‐Gomez Angela Ollero‐Ortiz Ana M. Roa‐Montero María J. Gómez‐Baquero Ana B. Constantino‐Silva | 2013 | Int J Stroke2013，，6： | 1 |
| 6 | Graft and viral outcomes in retransplantation for hepatitis C virus recurrence and HCV primary liver transplantation: a case–control study显示文摘 | Josep Martí Sofia De la Serna Gonzalo Crespo Xavier Forns Joana Ferrer Constantino Fondevila Miquel Navasa Josep Fuster Juan Carlos García‐Valdecasas | 2014 | Clin Transplant2014，，7： | 1 |
| 7 | 显示文摘 | Izumi C M S Constantino V R L Ferreira A M C | 2006 | Synth Met2006，156，910： | 1 |
| 8 | Combined effects of photoperiod and salinity ongrowth,survival,and osmoregulatory ability oflarval southern flounder Paralichthys lethostigma显示文摘 | CONSTANTINOS T MOUSTAKAS WADE O WATANABE K A COPELAND | 2004 | Aquaculture2004，229，： | 1 |
| 9 | Nanostructured films of perylene derivatives: High performance materials for taste sensor applications 显示文摘 | CONSTANTINO C J L ANTUNES P A VENANCIO E C | 2004 | Sensor Letters2004，2，2： | 1 |
| 10 | Mierodialysis: use in the assessment of a buried bone-only fibular free flap显示文摘 | Constantinos M Rajiv A John B | 2007 | Plast Reconstr Surg2007，120，5： | 1 |
| 11 | Rapid synchronous fluorescence method for virgin olive oil adulteration assessment 显示文摘 | Konstantina I Poulli George A Mousdis Constantinos A Georgiou | 2007 | Food Chemistry2007，105，： | 1 |
| 12 | Interaction mechanism of poly ( o - ethoxyani- line) and collagen blends 显示文摘 | PIZA M A CONSTANTINO C J L VENANCIO E C | 2003 | Polymer2003，44，： | 1 |
| 13 | Detección del shunt intrapulmonar en pacientes con cirrosis hepática mediante doppler transcraneal con contraste. Estudio de prevalencia, caracterización del patrón y validez diagnóstica显示文摘 | José María Ramírez Moreno María Victoria Millán Nú?ez Marta Rodríguez Carrasco David Ceberino Olena Romaskevych-Kryvulya Ana Belén Constantino Silva Pedro Mu?oz-Vega Carmen García-Corrales Ana Guiberteau-Sánchez Ana Roa Montero Patricia Márquez-Lozano Isi | 2015 | Gastroenterologia y Hepatologia2015，，8： | 1 |
| 14 | Layered H2K2Nb6O17 exfoliation promoted by n-butylamine 显示文摘 | Bizeto M A Constantino V R L | 2004 | Materials Research Bulletin2004，39，： | 1 |
| 15 | Surface Potentials of Polyaniline LB Films显示文摘 | Constantino C J L Dhanabalan A Riul Jr A | 1999 | Synthetic Metals1999，101，： | 1 |
| 16 | Aromatic gold and silver Rings': Hydrosilver(1) and hydrogold(D显示文摘 | Constantinos A Tsipis Athanassios C Tsipis | 2004 | J Am Chem Soc2004，126，12： | 1 |
| 17 | Use of dexme-detomidine in children after cardiac and thoracic sui^ery 显示文摘 | Chrysostomou A Constantinos M D Filippo D | 2006 | Pediatric Critical Care Med2006，7，2： | 1 |
| 18 | Kinetic Study of N-Bromosuccinimide Reactions and Kinetic Determination of Pyridoxine Using a Bromide-selective Electrode显示文摘 | Stergios A Halvatzis Meropi M Timotheou-Potamia Constantinos E Efstathiou | 1993 | Talanta1993，40，8： | 1 |
| 19 | Spectroscopic characterization of doped poly (benzidine) and its nanocomposite with Cationic Clay 显示文摘 | Nascimento G M Constantino V R L Temperini M L A | 2004 | J Phys Chem B2004，108，18： | 1 |
| 20 | Edible oil analysis by flow injection 显示文摘 | Nikolaos S Thomaidis Constantinos A Georgiou | 1999 | Laboratory Automation and Information Management1999，34，2： | 1 |
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