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| 1 | Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats显示文摘Objective To evaluate the influence of an extract of Genista tinctoria L. herba(GT) or methylparaben(MP) on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A(BPA). Methods Adult female Wistar rats were orally exposed for 90 d to BPA(50 mg/kg), BPA+GT(35 mg isoflavones/kg) or BPA+MP(250 mg/kg). Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA+MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA+MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes. | Daniela-Saveta POPA Pompei BOLFA Bela KISS Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 2 | Sensitivity estimation within first and second order reliability methods显示文摘 | Karamchandani A Cornell C A | 1991 | Structural Safety1991，11，2： | 1 |
| 3 | Incremental dynamic analysis 显示文摘 | Dimitrios Vamvatsikos C Allin Cornell | 2002 | Earthquake Engineering And Structural Dynamics2002，31，： | 1 |
| 4 | Engineering seismic risk analysis显示文摘 | Cornell C A | 1968 | Bulletin of the Seismological Society of America1968，58，5： | 1 |
| 5 | Structure-specific scalar intensity measures for near-source and ordinary earthquake ground motions 显示文摘 | Luco N Cornell C A | 2007 | Earthquake Spec- tra2007，23，357： | 1 |
| 6 | Incremental dynamic analysis显示文摘 | Vamvatsikos D Cornell C A | 2002 | Earthquake Engineering and Structural Dynamics2002，31，3： | 1 |
| 7 | Preoperative puhnonary risk stratification for noncardiothoracic surgery: systematic review for the American college of physicians 显示文摘 | Smetana C W Lawrence VA Cornell JE | 2006 | Ann Intern Med2006，144，8： | 1 |
| 8 | Cell-dependent role for the poliovirus 3' noncoding region in positive-strand RNA synthesis显示文摘 | Brown D M Kauder S E Cornell C T | 2004 | J Virol2004，78，3： | 1 |
| 9 | Probabilistic basis for 2000 SAC federal emergencymanagement agency steel moment frame guidelines 显示文摘 | Cornell C A Jalayer F Hamburger R 0 | 2002 | Journal of Structural Engineering-ASCE2002，128，4： | 1 |
| 10 | Controlled preparation of the endometrium with exogenous estradiot and progesterone in women having functioning ovaries 显示文摘 | de Ziegler D Cornel C Bergeron C | 1991 | Fertil Steril1991，56，： | 1 |
| 11 | Incremental dynamic analysis显示文摘 | VAMVATSIKOS D CORNELL C A | 2002 | Earthquake Engineering and Structural Dynamics2002，31，3： | 1 |
| 12 | Applied incremental dynamic analysis显示文摘 | Vamvatisikos D Cornell C A | 2004 | Earthquake Spectra2004，20，2： | 1 |
| 13 | Engineering seismic risk analysis 显示文摘 | Cornell C A | 1968 | Bulletin of the Seismological Society of America1968，58，6： | 1 |
| 14 | Determination of pyrazine and flavor variations inpeanutgenotypes during roasting显示文摘 | Baker G L Cornell J A Gorbet D W Okeefe S F Sims C A Talcott ST | 2003 | Journal of Food Science2003，68，1： | 1 |
| 15 | Incrementaldynamic analysis 显示文摘 | VAMVATSIKOS D CORNELL C A | 2002 | Earthquake Engineering &Structural Dynamics2002，31，3： | 1 |
| 16 | MWIR continuous zoom with large zoom range显示文摘 | Sanson M C Cornell J | | 0，，： | 1 |
| 17 | Structure-specific scalar inteasi- ty measures for near-source and ordinary earthquake ground motions显示文摘 | Luco N Cornell C A | 2007 | Earthquake Spectra2007，23，2： | 1 |
| 18 | Developing efficient scalar and vector intensity measures for IDA capacity estimation by incorporating elastic spectral shape information显示文摘 | Vamvatsikos D Cornell C A | 2005 | Earthquake Engineering and Structural Dynamics2005，34，3： | 1 |
| 19 | Role of Niobium as an Alloying Element in Cast Irons 显示文摘 | C Loper H Bands H Cornell | 1988 | International Symposium on Tantalum and Niobium1988，11，： | 1 |
| 20 | Bounds on the Reliability of Structural Systems显示文摘 | CORNELL C A | 1967 | Journal of the Structural Division1967，93，1： | 1 |
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