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| 1 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010,16,31: | 10 |
| 2 | Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity显示文摘 | Corbin Amie S Agarwal Anupriya Loriaux Marc Cortes Jorge Deininger Michael W Druker Brian J | 2011 | Journal of Clinical Investigation2011,,1: | 3 |
| 3 | Sleep disordered breathing in interstitial lung disease: A review显示文摘Patients with interstitial lung disease commonly exhibit abnormal sleep architecture and increased sleep fragmentation on polysomnography. Fatigue is a frequent complaint, and it is likely that poor sleep quality is a significant contributor. A number of studies have shown that sleep disordered breathing is prevalent in this population, particularly in the idiopathic pulmonary fibrosis subgroup. The factors that predispose these patients to obstructive sleep apnoea are not well understood, however it is believed that reduced caudal traction on the upper airway can enhance collapsibility. Ventilatory control system instability may also be an important factor, particularly in those with increased chemo-responsiveness, and in hypoxic conditions. Transient, repetitive nocturnal oxygen desaturation is frequently observed in interstitial lung disease, both with and without associated obstructive apnoeas. There is increasing evidence that sleep-desaturation is associated with increased mortality, and may be important in the pathogenesis of pulmonary hypertension in this population. | Lauren K Troy Tamera J Corte | 2014 | World Journal of Clinical Cases2014,2,12: | 2 |
| 4 | Adaptive randomized study of idarubicin and cytarabine versus troxacitabine and cytarabine versus troxaeitabine and idarubicin in untreated patient 50 years or older with adverse karyotype acute myeloid leukemia 显示文摘 | Giles F J Kantar JHM Cortes JE | 2003 | J Clin Oncol2003,21,9: | 1 |
| 5 | TiO2-catalysed ozonation of raw Ebro river water显示文摘 | Cortes S Sarasa J | 2000 | Water Res2000,34,: | 1 |
| 6 | Molecular biology of BCR-ABL positive chronic myeloid leukemia 显示文摘 | Quintas-Cardama A Cortes J | 2009 | Blood2009,113,8: | 1 |
| 7 | Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase显示文摘 | Kantarjian HM Cortes J O'Brien S | 2002 | Blood2002,99,10: | 1 |
| 8 | Coordination and geometric optimi- zation via distributed dynamical systems 显示文摘 | CORTES J BULLO F | 2006 | The SIAM Journal on Control and Optimization2006,44,5: | 1 |
| 9 | Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage显示文摘 | Cortes J Wiesmann K Roberts GA | 1995 | Science1995,268,5216: | 1 |
| 10 | Tyrosine kinase inhibitors in acute and chronic leukemias显示文摘 | OHANIAN M CORTES J KANTARJIAN H | 2012 | Expert Opin Pharmacother2012,13,7: | 1 |
| 11 | Molecular biology of bcr- abll- positive chronic myeloid leukemia 显示文摘 | Quintas- Cardama A Cortes J | 2009 | Blood2009,113,8: | 1 |
| 12 | Long - term follow - up of pa- tients with hypereosinophilic syndrome treated with Alemtuzum- ab,an anti- CD52 antibody 显示文摘 | Strati P Cortes J Faded S | 2013 | Clinical lymphoma Myeloma Leuke2013,13,3: | 1 |
| 13 | The whole relationship between environmental variables and finn performance: competitive advantage and firm resources as mediator variables 显示文摘 | LOPEZ- GAMERO M D MOLINA -AZORIN J F CLAVER- CORTeS E | 2009 | Journal of environmental management2009,90,10: | 1 |
| 14 | Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study显示文摘 | Cortes J O'Shaughnessy J Loesch D | 2011 | Lancet2011,377,9769: | 1 |
| 15 | Shallow tunnels in cohesionless soil:Stability of tunnel face显示文摘 | CHAMBON P CORTE J F | 1994 | Journal of Geotechnical Engineering1994,120,7: | 1 |
| 16 | The role retinoid defi- ciency and estrogens as cofactors in cervical cancer显示文摘 | GARIGLIO P GUTIERREZ J CORTES E | 2009 | Arch Med Res2009,40,6: | 1 |
| 17 | Outcome with the hyper-CVAD regimens in lymphoblastic lymphoma显示文摘 | THOMAS D A O'BRIEN S CORTES J | 2004 | Blood2004,104,: | 1 |
| 18 | Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older显示文摘 | Faderl S Verstovsek S Cortes J | 2006 | Blood2006,108,1: | 1 |
| 19 | Pilot study of low-dose interleukin-Ⅱ in patinets with bone marrow failure显示文摘 | Kurzrock R Cortes J Thomas DA | 2001 | J Clin Oncol2001,19,21: | 1 |
| 20 | Current issues in chronic myeloid leukemia: monitoring, resistance, and functional cure显示文摘 | CORTES J GOLDMAN JM HUGHES T | 2012 | J Natl Compr Canc Netw2012,103,: | 1 |